Clinical trials: Painful
Skin Aging of Dorsal Hands
Comparing Pain, Safety and Effectiveness of Restylane Skinboosters Vital Lido and Vital Without Lido in Dorsal Hand
This is a randomized, multi-center, split-hand, subject-blinded study comparing pain, safety and effectiveness of Restylane Skinboosters Vital Lidocaine and Restylane Vital without lidocaine for improving appearance of the dorsal…
- Trial name
- NCT06372782
- Testing
- Restylane Skinboosters Vital Lidocaine, Restylane Vital
- Where
- 3 sites in China
- Volunteers
- 90 people
- Sponsor
- Galderma R&D
Migraine, Headache
Efficacy and Safety of a Fixed-dose Combination of Naratriptan and Naproxen in Acute Treatment of Migraine
The purpose of this study is to determine whether a fixed-dose combination of naratriptan + naproxen is effective compared each monotherapy for the acute treatment of migraine.
- Trial name
- Atenéia (NCT01390324)
- Testing
- Fixed-dose combination of naratriptan+naproxen, Naratriptan, Naproxen
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Pain
A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects
To evaluate the relative bioavailability of Naproxen Sodium 220 mg and diphenhydramine hydrochloride (DPH HCL) 25 mg soft capsules (Test) versus Naproxen Sodium 220 mg and diphenhydramine hydrochloride 25 mg tablets (Reference)…
- Trial name
- NCT03396250
- Testing
- Naproxen sodium and diphenhydramine hydrochloride soft capsules, Naproxen sodium and diphenhydramine hydrochloride coated tablets (Aleve, PMBAY98-7111)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Pain
Digital Signals in Chronic Pain (DiSCover Project)
The DiSCover Project is a 1-year longitudinal case-control observational study. In this study, the investigators plan to collect different types of data including self-reported health outcomes and quality of life data, behavioral…
- Trial name
- NCT03421223
- Testing
- No intervention
- Where
- United States
- Volunteers
- 10,161 people, healthy volunteers welcome
- Sponsor
- Evidation Health
Pain
Naproxen Sodium ER Pharmacokinetic Study
To determine the pharmacokinetic profile of the investigational product following dosing under fed conditions.
- Trial name
- NCT00818415
- Testing
- Naproxen sodium ER (BAYH6689), Commercial Naproxen (Aleve, BAYH6689)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Low Back Pain, Leg Pain
Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis
The purpose of this multi-center, randomized, clinical study is to establish the safety and effectiveness of the TOPS™ System, used following decompression, in the treatment of lower back and leg pain with, or without spinal…
- Conditions
- Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
- Trial name
- NCT00405691
- Testing
- "TOPS System" - Total Posterior Arthroplasty Implant
- Where
- 16 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Impliant, Ltd.
Analgesia Disorder
Study of PHN131 in Patients After Surgery
The purpose of this study is to assess the effectiveness, safety and pharmacokinetics of Oral Nalbuphine in the treatment of postoperative pain following hemorrhoidectomy.
- Trial name
- NCT02193620
- Testing
- PHN131 soft capsule with Nalbuphine HCl 60 mg/cap, Diclofenac
- Where
- Taiwan
- Volunteers
- 106 people
- Sponsor
- PhytoHealth Corporation
Chronic Pain
Clinical Study on a Novel Minimally Invasive Posterior Sacroiliac Fusion Device
The PainTEQ study is a prospective, multi-site, prospective, single arm study intended to collect clinical data outcomes data associated with the treatment of sacroiliac disease with the LinQ fusion procedure.
- Trial name
- NCT04423120
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- PainTEQ, LLC
Sickle Cell Disease
A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)
This study is designed to evaluate the efficacy, safety and pharmacokinetics of crovalimab compared with placebo as adjunct therapy in the prevention of VOEs in participants with SCD.
- Trial name
- CROSSWALK-c (NCT05075824)
- Testing
- Crovalimab
- Where
- 27 sites in United States, Brazil and 9 more
- Volunteers
- 95 people
- Sponsor
- Hoffmann-La Roche
Painful Lumbar Radiculopathy, Healthy
Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)
The primary objective of the study is to evaluate the safety and tolerability of a range of single intravenous (IV) and subcutaneous (SC) doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in…
- Trial name
- NCT01842126
- Testing
- BG00010 IV, BG00010 SC
- Where
- Netherlands
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Biogen
Pain, Phlebotomy
Synera Venipuncture Pain
Synera, which is a heated topical patch containing both lidocaine and tetracaine, is intended to reduce the pain associated with venipuncture and superficial dermatologic procedures by numbing the skin.
- Conditions
- Pain, Phlebotomy, Palliative Care
- Trial name
- NCT01744197
- Testing
- Synera (lidocaine 70mg/tetracaine 70mg)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- US Oncology Research
Ankle and Hindfoot Arthrodesis
Long-term Safety and Effectiveness of AUGMENT® Bone Graft Compared to Autologous Bone Graft
The objective of this long-term study is to evaluate the long term effectiveness and safety of AUGMENT® Bone Graft vs. autologous bone graft.
- Trial name
- NCT02879149
- Testing
- AUGMENT® Bone Graft, Standard of Care
- Where
- 26 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- BioMimetic Therapeutics
Aging, Pain
RHA® Redensity With New Anesthetic Agent - Perioral Rhytids
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® Redensity with new anesthetic agent is non-inferior to RHA® Redensity with lidocaine in…
- Trial name
- NCT04069585
- Testing
- RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Low Back Pain
Evaluation of the Effect of Lumbar Belt on Spinal Mobility in Subjects With and Without Low Back Pain
Low back pain (LBP) is a common condition worldwide as the lifetime prevalence is up to 80%. It is defined as pain in the lumbosacral region in which the etiological causes are most often mechanical, and it is therefore defined…
- Trial name
- LombaMob (NCT05600543)
- Testing
- Lumbar belt, Lombaskin lumbar belt and the Lyne Up percko postural T-shirt.
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Thuasne
Chronic Migraine, Chronic Migraine, Headache
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
This is a phase 2, double-blind, randomized, multicenter, placebo-controlled, three arm parallel study to evaluate the efficacy and safety of two different dosages (30 IU daily and 60 IU daily) of TNX-1900 in patients with…
- Conditions
- Chronic Migraine, Chronic Migraine, Headache, Chronic Migraine Without Aura, Aura Migraine
- Trial name
- PREVENTION (NCT05679908)
- Testing
- TNX-1900
- Where
- 26 sites in United States
- Volunteers
- 88 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Defective; Circulation
Study of Low Level Laser Light Therapy to Improve Blood Circulation in People With Chronic Heel Pain
The purpose of this study is to determine whether low level laser light therapy is effective in increasing local blood circulation in people with chronic heel pain arising from plantar fasciitis.
- Trial name
- NCT01882725
- Testing
- Erchonia HP Scanner (HPS)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Erchonia Corporation
Lower Back Pain, Facets Joints Osteoarthritis
Safety and Efficacy of MRgFUS for the Treatment of Low Back Pain
Chronic pain affects an estimated 50 to 65 million individuals in the US, and its incidence and prevalence is steadily on the rise in correspondence with the increasing longevity of the population.
- Trial name
- NCT01232582
- Testing
- Exablate treatment
- Where
- 2 sites in Israel, United Kingdom
- Volunteers
- 50 people
- Sponsor
- InSightec
Total Knee Arthroplasty
Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
This study is designed to investigate whether iovera° treatment prior to TKA decreases cumulative participant opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief.
- Trial name
- NCT03327220
- Testing
- iovera°
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT06628908
- Testing
- Suzetrigine, Pregabalin
- Where
- 76 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Pain
A Study to Look at Tapentadol Oral Solution in Children and Adolescents in Pain
The purpose of the study was to evaluate the efficacy of tapentadol oral solution, based on the total amount of supplemental opioid analgesic used over 12 hours or 24 hours after initiation of investigational medicinal product…
- Trial name
- NCT02081391
- Testing
- Tapentadol oral solution 4 mg/mL, Tapentadol oral solution 20 mg/mL
- Where
- 43 sites in United States, Bulgaria and 8 more
- Volunteers
- 216 people
- Sponsor
- Grünenthal GmbH