Clinical trials: Painful
Postoperative Pain
Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery.
this study will be undertaken to evaluate the safety and analgesic efficacy of adding ketamine to bupivacaine in bilateral infra-orbital nerve block for relief of pain postoperatively following repair of cleft lip in children…
- Trial name
- IFONB (NCT02514980)
- Testing
- Bupivacaine, Ketamine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Postoperative Pain Intensity
Effect of Opioid-Free Versus Opioid-Based Anesthesia in Discectomy Surgery
This prospective randomized double-blind clinical trial compares opioid-free anesthesia (OFA) versus opioid-based anesthesia (OBA) on postoperative analgesia in patients undergoing elective lumbar discectomy surgeries at Zagazig…
- Trial name
- NCT07787858
- Testing
- Dexmedetomidine and Ketamine-based Opioid-free Anesthesia, Fentanyl-based Opioid Anesthesia
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Zagazig University
Chronic Pain, Ankle Fracture Surgery
Anesthesia for Pain After Ankle Fracture Surgery
This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture compared to standard of care.
- Conditions
- Chronic Pain, Ankle Fracture Surgery, Regional Anesthesia
- Trial name
- NCT02950558
- Testing
- Ropivacaine, Nerve block
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Cincinnati
Caesarean Section
Comparison of Postoperative Pain Between Patients Received Primary and Repeated Caesarean Section
To everyone knows, more and more patients received repeated caesarean section in China. However, at present it is not known what is it like about their postoperative pain intensity, and is it different from those patients who…
- Trial name
- NCT03009955
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Xinqiao Hospital of Chongqing
Impacted Mandibular Third Molar Extraction, Impacted Lower Third Molar
Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery
This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing…
- Conditions
- Impacted Mandibular Third Molar Extraction, Impacted Lower Third Molar, Impacted Wisdom Tooth
- Trial name
- NCT07742826
- Testing
- Platelet-rich fibrin (PRF), Dexamethasone, Amoxicillin/Clavulanic Acid
- Where
- Cyprus
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Final International University
Healthy Volunteer
Brain Effect of Vagal Nerve Stimulation at Rest and Pain
Pain is a ubiquitous distressing sensory experience and is the most frequent symptom in numerous gastrointestinal disorders including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
- Trial name
- NCT04282226
- Testing
- active transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Traumatic Brain Injury, Chronic Pain
One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change
Mild traumatic brain injury (mTBI) is the signature wound of Veterans returning from the operations in Iraq and Afghanistan (i.e., OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury, Chronic Pain, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT04143243
- Testing
- ACT on Life, Education, Resources, and Support
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Pain, Postoperative
Comparison of Post-operative Pain Frequency
The objective of this study is: To compare the post-operative pain frequency after single visit root canal versus multiple visit root canal treatment in patients with non-vital teeth Post-operative pain is less frequent after…
- Trial name
- NCT04944589
- Testing
- ROOT CANAL TREATMENT
- Where
- Pakistan
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Fatima Memorial Hospital
Cancer Pain
Efficacy of Biofeedback-Based Serious Game for Pain Alleviation in Middle-Aged and Older Ovarian Cancer Patients: A Randomized Controlled Trial
Consistent pain affects most middle-aged and older ovarian cancer patients. Non-pharmacological pain interventions, such as serious games, offer a promising approach to alleviating this pain by providing an effective sense of…
- Trial name
- NCT06612489
- Testing
- biofeedback based dynamic-difficulty game, fixed difficulty game
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Postoperative Pain
Ultrasound Guided Intermediate Cervical Plexus Block in Thyroid Surgery
studying the effect of dexmeditomidine addition to bupivacaine in bilateral intermediate cervical block for patients undergoing thyroidectomy under general anaesthesia
- Trial name
- NCT03731468
- Testing
- local anesthetic, Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pain
A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects
To evaluate the relative bioavailability of Naproxen Sodium 220 mg and diphenhydramine hydrochloride (DPH HCL) 25 mg soft capsules (Test) versus Naproxen Sodium 220 mg and diphenhydramine hydrochloride 25 mg tablets (Reference)…
- Trial name
- NCT03396250
- Testing
- Naproxen sodium and diphenhydramine hydrochloride soft capsules, Naproxen sodium and diphenhydramine hydrochloride coated tablets (Aleve, PMBAY98-7111)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bayer
Fibromyalgia
Influence of Transcranial Direct Current Stimulation of the Primary Motor Cortex on Pain Sensation in Patients Suffering From Fibromyalgia Syndrome
Fibromyalgia is a common chronic pain syndrome characterized by bad treatable chronic widespread pain present at a similar level for at least 3 months.
- Trial name
- NCT01261650
- Testing
- transcranial direct current stimulation
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Karl Landsteiner Institute of Remobilization and Functional Health
Postoperative Pain, Pain Management
The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain
Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery.
- Conditions
- Postoperative Pain, Pain Management, Rebound Pain, Interscalene Block
- Trial name
- NCT07642674
- Testing
- ISB + paracetamol IV 3*1, ISB+ paracetamol IV 3*1 +deksketoprofen IV 2*1
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Eskisehir Osmangazi University
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
Orthopaedic Surgery, Upper Extremity
The Effect of Pain Neuroscience Education on Preoperative Anxiety and Postoperative Recovery in Patients Scheduled for Orthopedic Surgery
This study aimed to investigate the effects of preoperative PNE on preoperative anxiety, pain-related beliefs, and postoperative functional outcomes in patients undergoing upper extremity orthopedic surgery.
- Trial name
- NCT07107360
- Testing
- Pain Neuroscience Education, Conventional preoperative education
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Atlas University
Postoperative Pain
Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy
The role of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in patients undergoing hysterectomy remains scarcely explored.
- Trial name
- NCT03908060
- Testing
- Methadone, Morphine
- Where
- Denmark
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Meralgia Paresthetica
The Efficacy of High-Power Laser Therapy in Meralgia Paresthetica
The management of MP typically follows a conservative pathway, encompassing patient education, lifestyle modifications (e.g., avoidance of tight garments, weight loss), pharmacotherapy (such as neuropathic pain agents or…
- Trial name
- NCT07328360
- Testing
- High-power laser, Standard Conservative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uşak University
Postoperative Pain
Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.
ECS is a very common procedure. A 1-year retrospective survey revealed a vast opioid consumption among the new mothers of approximately (mean±SD) 35±25 mg of oral morphine in the first 24 postoperative hours despite a multimodal…
- Trial name
- NCT03068260
- Testing
- Ropivacaine, Saline, Acetaminophen
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Patient Satisfaction
Predicting Ultrasound-Guided Thoracic PVB Success in Herpetic Neuralgia
This study aims to fill the knowledge gap by investigating the predictors of success for TPVB in patients with herpetic neuralgia.
- Trial name
- NCT06761924
- Testing
- Ultrasound-Guided Thoracic Paravertebral nerve block
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Beni-Suef University
ACL, Postoperative Pain
Exparel vs Block for ACL Reconstruction
Liposomal bupivacaine or Exparel (Pacira Biosciences) is a long-lasting nonopioid analgesic that was initially utilized as an infiltrative agent but has more recently become U.S.
- Trial name
- NCT06006624
- Testing
- Exparel 30 mL, 0.5% bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
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