Clinical trials: Painful
Chronic Low Back Pain (CLBP)
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
The purpose of the ASTRAL Study is to evaluate the effectiveness of LRFA (Lumbar radiofrequency ablation) against a control procedure.
- Trial name
- ASTRAL (NCT07222462)
- Testing
- Lumbar radiofrequency ablation with conventional electrodes (LRFA-C), Lumbar radiofrequency ablation with multi-tined electrodes (LRFA-M), Simulated lumbar radiofrequency ablation
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Washington
Intra-uterine Device Placement
Pain Associated wIth traditioNal Versus uLtrasound guidEd iuS (Intra Uterine System) inSertion
Rationale: The 2019 Belgian Health Survey shows that the combined oral contraceptive pill is the most commonly used form of contraception.
- Trial name
- PAINLESS (NCT07315646)
- Testing
- IUS (intrauterine system) insertion
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Occupational Exposure, Musculoskeletal Pain
Can Work be Organized to Become More Health Promoting for Employees in Home Care Services?
This is a two-group, cluster randomized controlled trial designed to assess a health promoting intervention in the home care sector.
- Conditions
- Occupational Exposure, Musculoskeletal Pain, Work-related Injury, Low Back Pain
- Trial name
- GoldiCare (NCT05487027)
- Testing
- Goldilocks work principle
- Where
- 11 sites in Norway
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Spinal Cord Injuries
Tenodesis Grip Strength With Functional Hand Recovery in Cervical Spinal Cord Injury
Spinal cord injury (SCI) is devastating event, the individual become significant burden on their family and society SCI is impairments of sensory, motor and autonomic functions.
- Trial name
- NCT05356442
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Low Back Pain
The Effects Of Equal Breathing On Pain Pressure Thresholds
Recent research has found that there is moderate evidence for the use of breathing exercises for treating chronic, non-specific low back pain.
- Trial name
- EB-Pain (NCT03353142)
- Testing
- Equal Breathing
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Laparoscopic Surgery, Visceral Pain, Postoperative
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery
Visceral pain following laparoscopic surgery is frequently underestimated, yet it is associated with a range of adverse outcomes.
- Conditions
- Laparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous Analgesia
- Trial name
- NCT07525986
- Testing
- High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon
- Where
- 4 sites in China
- Volunteers
- 140 people
- Sponsor
- Peking University First Hospital
Irreversible Pulpitis
Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain
The aim of this study is premedication efficacy of analgesics on post endodontic pain. Sixty-six healthy adult volunteers including criteria, are participating.
- Trial name
- NCT02614118
- Testing
- Ketorolac tromethamine, Acetaminophen
- Where
- Iran
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Postoperative Pain, Breast Cancer
Administration of Ketamine to Prevent the Post-operative Pain
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse…
- Trial name
- KETAMINE (NCT00210210)
- Testing
- Ketamine, Saline solution
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Institut Bergonié
Anxiety, Pain
Effects of Music on Preoperative Anxiety in Patients With Femoral Fractures Undergoing Surgery
This randomized controlled trial (RCT) investigates the effectiveness of music therapy in reducing preoperative anxiety among elderly patients with femoral fractures.
- Conditions
- Anxiety, Pain, Surgery, Femoral Fractures
- Trial name
- NCT07008482
- Testing
- Music intervention
- Volunteers
- 154 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Esophageal Spasm, Diffuse
Botulinum Toxin Injection to Treat Diffuse Esophageal Spasm
This study evaluates the effect of botulinum toxin 100 U or saline, injected endoscopically in the distal esophagus, on symptoms and manometry pattern in patients with diffuse esophageal spasm.
- Trial name
- Botox (NCT01432782)
- Testing
- Botulinum Toxin Type A
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Pain
TAP Block vs CWI for Total Abdominal Hysterectomy, a RCT
This no-profit, monocentric, prospective randomized controlled trial, aims to demonstrate the non-inferiority of continuous wound infusion (CWI) when compared to transversus abdominis plane (TAP) block for postoperative pain…
- Trial name
- WI-HYSTER (NCT05686382)
- Testing
- Continuous Wound Infusion, TAP block
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Campus Bio-Medico University
Barrett Esophagus
Balloon Cryotherapy vs. Radiofrequency Ablation Pain Study
Barrett's esophagus is a condition in which the normal lining of the lower esophagus is replaced with cells that predispose an individual to development of esophageal cancer.
- Trial name
- NCT03387982
- Where
- 4 sites in United States
- Volunteers
- 95 people
- Sponsor
- Geisinger Clinic
Low Back Pain
Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits.
- Trial name
- NCT04912388
- Testing
- Lumbal stabilization excercises, Conventional exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pelvic Pain
Change of Range of Motion of TMJ After Correction of Pelvic a Symmetry in Women With Cyclic Pelvic Pain
Clinical experiences have shown that significant pain regression during a menstrual cycle has been often achieved by the use of spinal manipulative therapy (SMT) indicated in women with primary dysmenorrhea with coexisting…
- Trial name
- NCT04077788
- Testing
- muscle energy technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Trauma Injury, Pain
Ketamine for Acute Pain Management After Trauma
The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.
- Conditions
- Trauma Injury, Pain, Opioid Use
- Trial name
- KAPT (NCT04129086)
- Testing
- Ketamine plus usual care, Usual Care
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- The University of Texas Health Science Center, Houston
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
The purpose of this study was to compare the effects of FX006 and Triamcinolone Acetonide Injectable Suspension, United States Pharmacopeia (USP) (referred to as TCA IR in the protocol) on blood glucose (BG) in patients with…
- Trial name
- NCT02762370
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain, Cystic Fibrosis
Pain in Patients With Cystic Fibrosis in Rouen University Hospital
Objectif Principal To evaluate the intensity and frequency of pain episodes in patients with cystic fibrosis followed at the cystic fibrosis center of Rouen University Hospital, Normandy, France.
- Trial name
- MUCODOL (NCT04561973)
- Testing
- numerical rating scale
- Where
- France
- Volunteers
- 109 people
- Sponsor
- University Hospital, Rouen
Hamstring Muscle Tightness, Muscle Strength
The Effects of Instrument-Assisted Soft Tissue Mobilization in Sedentary Individuals With Hamstring Tightness
The aim of this study will be to investigate and compare the effects of static stretching exercise, Instrument Assisted Soft Tissue Mobilization (IASTM), and functional IASTM techniques on hamstring muscle shortness, pain…
- Conditions
- Hamstring Muscle Tightness, Muscle Strength, Pain Threshold
- Trial name
- NCT07091383
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cyprus International University
Labor Pain, Epidural Analgesia for Labour and Delivery
Early Labor Pre-Marking for Epidural Analgesia: Ultrasound vs Manual Palpation
The goal of this clinical trial is to learn if finding and marking the best spot on the back early in labor helps doctors perform epidural pain relief more successfully in pregnant women.
- Conditions
- Labor Pain, Epidural Analgesia for Labour and Delivery, Neuraxial Ultrasound
- Trial name
- NCT07669441
- Testing
- Preprocedural Spinal Ultrasound, Conventional Landmark Palpation
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Pain, Opioid Use
Microcurrent Treatment for Chronic Debilitating Pain
To compare the efficacy of standard pain treatment and placebo (a microcurrent faux treatment) as opposed to standard pain treatment and microcurrent therapy in any primary care patients over a three month period.
- Trial name
- NCT04011176
- Testing
- Standard treatment + Microcurrent Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Paul Crawford
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