Clinical trials: Painful
Low Back Pain, Osteoarthritis
Long-term Open-Label Safety Study to Evaluate EN3409
The purpose of the long-terms study is to evaluate the safety, tolerability, and analgesic efficacy of EN3409 in subjects with moderate to severe chronic pain requiring continuous around-the-clock opioid analgesia for an extended…
- Conditions
- Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01755546
- Testing
- EN3409
- Where
- 57 sites in United States
- Volunteers
- 304 people
- Sponsor
- BioDelivery Sciences International
Interstitial Cystitis, Mindfulness
Mindfulness-Based Therapy for Interstitial Cystitis/Bladder Pain Syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood disease with unreliable treatments. Although it is not known what causes it for certain, we do know that life stressors may make the disease worse or…
- Conditions
- Interstitial Cystitis, Mindfulness, Complementary Medicine, Painful Bladder Syndrome
- Trial name
- NCT02457182
- Testing
- Mindfulness-based Stress Reduction (MBSR), Usual medical therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Painful Diabetic Neuropathy
Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy
Patients with painful diabetic neuropathy (PDN) often combine with anxiety and depression. However, the pathogenesis of PDN is unclear, especially the mechanism associated with central nervous system.
- Trial name
- NCT03700502
- Testing
- resting-state functional Magnetic Resonance Imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Diabetes Mellitus, Painful Diabetic Neuropathy
The Development of Contextual Cognitive Behavioural Approach to PDN
Diabetes mellitus (DM) is highly prevalent, and a significant public health problem. Approximately 25-30% of all individuals with DM develop painful diabetic neuropathy (PDN).
- Trial name
- NCT03700528
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Painful Diabetic Neuropathy
Trazodone in Painful Diabetic Neuropathy
The aim of the study is to collect preliminary information on the effect of low doses of trazodone on pain intensity in patients with painful diabetic neuropathy and to evaluate the neuropathic pain symptoms, anxiety, sleep…
- Trial name
- NCT03202979
- Testing
- Trazodone 20 mg, Trazodone 10 mg
- Where
- 20 sites in Czechia, Hungary and 1 more
- Volunteers
- 142 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Overactive Bladder, Urinary Urge Incontinence
Reduction of Bladder Injection Pain With Belladonna Opiate Suppository
The purpose of this study is to test whether using belladonna \& opiate suppositories (B\&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic, Painful Bladder Syndrome
- Trial name
- ROBIN (NCT02600715)
- Testing
- Onabotulinumtoxin A (BoNT), belladonna, Morphine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Edgar LeClaire, MD
Painful Myelopathy, Painful Neuropathy
Single Shot Intrathecal Ziconotide for Painful Neuropathy or Myelopathy
This is a phase 4 study being conducted at the Ohio State University Department of Neurology Multiple Sclerosis Research Program.
- Trial name
- NCT01992562
- Testing
- Ziconotide
- Where
- United States
- Sponsor
- Aaron Boster
Mechanically Ventilated Neonates, Painful Procedures in Newborns
Codeine in Mechanically Ventilated Neonates
The purpose of this study is to determine the absorption and bioavailability of codeine in relation to postnatal (PNA) and postconceptional (PCA) age; determine the parent drug (codeine), its active metabolites, their formation…
- Trial name
- NCT01322204
- Testing
- Codeine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Painful Neuropathy
Study of Sulfasalazine in Treating Painful Neuropathy
The investigators hypothesize that sulfasalazine, an FDA-approved medication for rheumatoid arthritis and ulcerative colitis, may be beneficial in neuropathic pain conditions.
- Trial name
- NCT01667029
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Risk Factors Associated With Painful Colonoscopy
Discomfort Score Identifies Painfulness During Unsedated Colonoscopy
Some patients felt no pain or only mild discomfort with the unsedated colonoscopy. However, unsedated colonoscopy was thought to be an option for some but not for all.
- Trial name
- NCT03540173
- Where
- 2 sites in China
- Volunteers
- 1,220 people
- Sponsor
- Air Force Military Medical University, China
Painful Diabetic Peripheral Neuropathy
Painful Diabetic Peripheral Neuropathy Study of Chinese OutPatiEnt
Painful Diabetic peripheral Neuropathy Study of Chinese OutPatiEnt (PDN-SCOPE): a multi-center cross-sectional registry study of clinical characteristics and treatment survey of PDN in China
- Trial name
- SCOPE (NCT03520608)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Peking University Third Hospital
Painful Bladder Syndrome
A Pilot Study Investigating the Use of a Therapeutic Wand in Addition to Physiotherapy for Bladder Pain Syndrome
Bladder pain syndrome is a condition where pain is experienced when the bladder fills with urine and eases briefly when the bladder empties. There can also be a constant need to urgently empty the bladder.
- Trial name
- NCT02743962
- Testing
- Therapeutic Wand, Routine physiotherapy control
- Volunteers
- 10 people
- Sponsor
- University of Bradford
Diabetic Neuropathy, Painful, Diabetic Neuralgia
Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN).
The purpose of this study is to evaluate the safety, effectiveness, and tolerability of 200 mg of RWJ-333369 given twice daily by mouth compared with placebo in the treatment of Diabetic Peripheral Neuropathy (DPN).
- Conditions
- Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy, Diabetic Mononeuropathy
- Trial name
- NCT00501202
- Testing
- RWJ-333369 (carisbamate)
- Volunteers
- 132 people
- Sponsor
- SK Life Science, Inc.
Non-diabetic Painful Peripheral Polyneuropathy, Postherpetic Neuralgia (PHN)
A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment
This study is comparing the efficacy and tolerability of Qutenza with that of pregabalin in patients suffering from peripheral neuropathic pain.
- Conditions
- Non-diabetic Painful Peripheral Polyneuropathy, Postherpetic Neuralgia (PHN), Peripheral Nerve Injury (PNI)
- Trial name
- ELEVATE (NCT01713426)
- Testing
- Qutenza, Pregabalin
- Where
- 98 sites in Armenia, Austria and 20 more
- Volunteers
- 568 people
- Sponsor
- Astellas Pharma Europe Ltd.
Interstitial Cystitis, Bladder Pain Syndrome
Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome
This study evaluates the effects of two doses of oral AQX-1125 on bladder pain and other urinary symptoms in subjects with interstitial cystitis/bladder pain syndrome.
- Conditions
- Interstitial Cystitis, Bladder Pain Syndrome, Painful Bladder Syndrome, Chronic Interstitial Cystitis
- Trial name
- LEADERSHIP 301 (NCT02858453)
- Testing
- AQX-1125 100 mg, AQX-1125 200 mg
- Where
- 120 sites in United States, Belgium and 10 more
- Volunteers
- 433 people
- Sponsor
- Aquinox Pharmaceuticals (Canada) Inc.
Painful Peripheral Diabetic Neuropathy
Nociceptive Pain Fiber Response
This study is designed to evaluate the effectiveness of the Provant Therapy System in improving localized nerve growth and skin perfusion in subjects with painful peripheral diabetic neuropathy of the foot.
- Trial name
- NCT02696070
- Testing
- Provant Therapy System
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Small Fiber Neuropathy
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy
Lacosamide is a functionalized amino acid with antinociceptive properties in inflammatory and neuropathic pain, and displays a unique mechanism: it enhances slow inactivation of Nav1.3, Nav1.7, and Nav1.8.
- Trial name
- NCT01911975
- Testing
- Lacosamide
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Cystitis, Interstitial, Painful Bladder Syndrome
A Safety and Efficacy Study of LiRIS® in Females With Interstitial Cystitis/Bladder Pain Syndrome
This is a safety and efficacy study of LiRIS® in females with interstitial cystitis/bladder pain syndrome.
- Trial name
- NCT02411110
- Testing
- LiRIS®
- Where
- 34 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Allergan
Post-Herpetic Neuralgia (PHN), Neuropathic Pain
A Study Into Pain Relief Given by ASP8477 for Peripheral Neuropathic Pain (Either Post-herpetic Neuralgia or Painful Diabetic Peripheral Neuropathy) and Its Safety
The purpose of this study is to assess the painkilling efficacy of ASP8477 relative to mock (placebo) in patients that have been diagnosed with painful diabetic peripheral neuropathy or postherpetic neuralgia determined by the…
- Conditions
- Post-Herpetic Neuralgia (PHN), Neuropathic Pain, Painful Diabetic Peripheral Neuropathy (PDPN)
- Trial name
- MOBILE (NCT02065349)
- Testing
- ASP8477
- Where
- 17 sites in Czechia, Germany and 2 more
- Volunteers
- 132 people
- Sponsor
- Astellas Pharma Europe B.V.
Painful Diabetic Neuropathy
An Evaluation of an SCCD on the Symptomatology of Painful DPN
This is a controlled trial to evaluate the efficacy of an Sequential Contraction Compression Device (SCCD) on the symptomatology of Painful Diabetic Neuropathy.
- Trial name
- NCT03331614
- Testing
- Flowaid FA-100 SCCD
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Rosenblum, Jonathan I., DPM