Clinical trials: Painful
Chronic Pain, Migraine
Evaluation of a Mind-body Based Application for the Treatment of Chronic/Persistent Pain.
We are investigating the effects of a mind-body based mobile application on the experience of chronic pain. Participants meeting our criteria for chronic pain (confirmed via self-report) will complete an online baseline…
- Conditions
- Chronic Pain, Migraine, Chronic Pain Syndrome
- Trial name
- NCT05090683
- Testing
- Mind-body mobile application
- Where
- Canada
- Volunteers
- 198 people
- Sponsor
- University of the Fraser Valley
Procedural Anxiety, Procedural Pain
Can Virtual Reality Reduce Pain and Anxiety During Blood Draw
Adult patients aged 18-50 undergoing blood draw for routine lab evaluation will be randomized to a control group or experimental group to assess if the use of virtual reality reduces procedural pain (primary outcome) and…
- Trial name
- NCT04449341
- Testing
- Oculus Go headset with Ocean Rift application
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- C.R.Darnall Army Medical Center
Colonic Polyp
Effect of Epinephrine on Post-polypectomy Pain
Epinephrine is widely used in endoscopic mucosal resection of large polyps to prevent post-polypectomy bleeding. No previous studies looked at increase in immediate post-polypectomy pain with the use of epinephrine.
- Trial name
- NCT04065451
- Testing
- Epinephrine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Indiana University
Major Depressive Disorder, Soft Tissue Discomfort Syndrome
Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue Discomfort Syndrome
The objective of this study is to determine the time course of duloxetine efficacy on the symptoms of Major Depressive Disorder (MDD)and on the symptoms of Soft Tissue Discomfort Syndrome(STDS) via use of 24-hour Actigraph™…
- Conditions
- Major Depressive Disorder, Soft Tissue Discomfort Syndrome, Pain
- Trial name
- NCT01035073
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Pain
Effects of Intravenous GSK3858279 on a Battery of Evoked Pain Tests in Healthy Volunteers
This study will evaluate the mechanistic basis for the analgesic effects of GSK3858279 in humans by using a battery of experimental pain assessments in healthy participants.
- Trial name
- NCT04114656
- Testing
- GSK3858279
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dysmenorrhea
Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060)
The purpose of this study was to evaluate the efficacy of the etonogestrel (ENG) + 17β-estradiol (E2) (MK-8342B) vaginal ring compared to placebo vaginal ring in the treatment of dysmenorrhea at Treatment Cycle 2.
- Trial name
- NCT02668822
- Testing
- ENG 125 μg + E2 300 μg vaginal ring (MK-8342B), Ibuprofen
- Volunteers
- 18 people
- Sponsor
- Organon and Co
Pain
Analgesic Effect of Perioperative Systemic Lidocaine in Patients Undergoing Unilateral Mastectomy Surgery
The aim of this study is to determine if perioperative systemic lidocaine administration will decrease the amount of opioid analgesics required in women undergoing mastectomy surgery.
- Trial name
- NCT00913003
- Testing
- Lidocaine
- Volunteers
- 22 people
- Sponsor
- Northwestern University
Opioid Use, Enhanced Recovery After Surgery
The Impact of Perioperative Ketamine Infusion on Surgical Recovery
In order to effectively treat surgical pain with the least amount of opioids required, a multi-modal approach must include medications with different mechanisms of actions at alternative receptors.
- Conditions
- Opioid Use, Enhanced Recovery After Surgery, Anesthesia, Ketamine
- Trial name
- NCT04625283
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1,570 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Pain
The Thrive Study: Improving Multimodal Physical Function in Adults With Heterogenous Chronic Pain
The investigators aim to conduct a randomized controlled trial to test the feasibility of a mind-body walking program compared to a health education program for individuals with chronic musculoskeletal pain.
- Trial name
- NCT05700383
- Testing
- GetActive-Fitbit, Healthy Living for Pain
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Femoro Acetabular Impingement
A Study Comparing Fascia Iliaca Blockade vs Extracapsular Local Field Infiltration With Liposomal Bupivacaine
The purpose of this study is to compare the effectiveness of fascia iliaca blockade vs local field infiltration with liposomal bupivicaine in controlling pain, narcotic utilization and falls in the postoperative period following…
- Trial name
- NCT04114058
- Testing
- liposomal bupivicaine, Fascia iliaca blockade
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Cedars-Sinai Medical Center
Upper Back Pain
Exploratory Efficacy Study of Guaifenesin in Upper Back Pain
Explore the clinical efficacy of 7-day treatment regimens of guaifenesin in order to investigate the evidence that guaifenesin is an effective treatment for upper back/neck/shoulder muscle spasm/stiffness and pain.
- Trial name
- NCT01562548
- Testing
- Guaifenesin
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- GlaxoSmithKline
Chronic Low-back Pain
The BEST Trial: Biomarkers for Evaluating Spine Treatments
The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)-sponsored clinical trial being conducted through the NIH Helping to End Addiction…
- Trial name
- BEST (NCT05396014)
- Testing
- Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM)
- Where
- 12 sites in United States
- Volunteers
- 1,014 people
- Sponsor
- University of North Carolina, Chapel Hill
Fibromyalgia
Study Of A Controlled Release Formulation Of Pregabalin In Fibromyalgia Patients
The purpose of this study is to evaluate the efficacy and safety of a controlled release formulation of pregabalin administered once daily as compared to placebo in the treatment of fibromyalgia.
- Trial name
- NCT01271933
- Testing
- pregabalin
- Where
- 52 sites in United States, Canada and 2 more
- Volunteers
- 441 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pain, Post-operative
Serratus Anterior Plane Block in Patients Undergoing Mastectomy
This is a randomized, interventional prospective study. Patients (n=66) undergoing mastectomies with or without tissue expander will be randomized to receive a supra-serratus or sub-serratus regional plane block prior to surgery.
- Trial name
- NCT03154658
- Testing
- Ropivacaine 0.35%
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Texas Southwestern Medical Center
Low Back Pain
Translation of Robotic Apparel for Alleviating Low Back Pain
This is a NIAMS-sponsored clinical trial being conducted through the NIH Helping to End Addition Long-term (HEAL) Initiative's Back Pain Consortium (BACPAC) Research Program.
- Trial name
- NCT05736393
- Testing
- Back Exosuit
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Boston University Charles River Campus
Radiculopathy Lumbar
A Two-part Proof-of-Concept Study Assessing the Safety and Efficacy of LAT8881 in Lumbar Radicular Pain
The study consists of two parts. Part A will evaluate the safety and tolerability of intravenous LAT8881 in healthy volunteers using an ascending dose schedule.
- Trial name
- NCT05298306
- Testing
- LAT8881
- Where
- Australia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Lateral Pharma Pty Ltd
Patellofemoral Pain Syndrome
Therapeutic Effect of Two Muscle Strengthening Programs in Patients With Patellofemoral Pain Syndrome
Introduction: The patellofemoral pain syndrome (SPF) is one of the most frequent pathologies generated by the knee joint. Conservative treatment with physiotherapy exercises reduces pain and improves functional capacity in the…
- Trial name
- NCT04011436
- Testing
- Strengthening program
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Postoperative Pain, Opioid Use
Improving Post-Operative Pain and Recovery in Gynecologic Surgery
This is a clinical investigation to determine the efficacy of rectal versus intravenous acetaminophen in patients undergoing a minimally invasive hysterectomy.
- Conditions
- Postoperative Pain, Opioid Use, Acetaminophen
- Trial name
- NCT04175509
- Testing
- Rectal acetaminophen, Intravenous acetaminophen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aultman Health Foundation
Anesthesia
Pain Outcomes After Anterior Cruciate Ligament Reconstruction With Posterior Capsular Marcaine Injection
Post-operative pain control following elective anterior cruciate ligament reconstruction continues to be a hurdle for orthopaedic surgeons.
- Trial name
- NCT02826551
- Testing
- Marcaine, Ice, Percocet
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Acute Pain
A Dose-ranging Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy
This study will evaluate the dose-response relationship and safety of VX-150 in treating acute pain following bunionectomy.
- Trial name
- NCT03764072
- Testing
- VX-150
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
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