Clinical trials: Painful Bladder Syndrome (PBS)
Bladder Pain Syndrome, Female Sexual Dysfunction
Effect of Intradetrusor onabotulinumtoxinA Injection Versus Conservative Management on Female Sexual Function in Patients With Bladder Pain Syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is estimated to affect 3.3 to 7.9 million women aged 18 years and older in the United States.
- Trial name
- NCT06729151
- Testing
- Onabotulinum toxin A, Conservative management (dietary and behavioral)
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Interstitial Cystitis, Painful Bladder Syndrome
Physical Therapy in Women With Interstitial Cystitis
There are many different treatments that doctors recommend for patients with IC/PBS. Only a few research studies have been done to evaluate treatments given to patients.
- Trial name
- IC03 (NCT00733603)
- Testing
- Global Therapeutic Massages (GTM), Myofascial Tissue Manipulation (MTM)
- Where
- 11 sites in United States, Canada
- Volunteers
- 81 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Interstitial Cystitis, Pelvic Pain
Correlating Ic/Pbs Symptoms With Urine Biomarkers
Completion of a brief survey tool and providing an urine specimen. The study purpose is to improve our understanding of interstitial cystitis and painful pelvic syndrome.
- Trial name
- NCT00817388
- Testing
- No intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Interstitial Cystitis, Bladder Pain Syndrome
Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS
This is a Phase 2, prospective, randomized, double-blind, placebo-controlled, multi-center, single-dose, pharmacodynamic study designed to evaluate the efficacy and safety of the combination product (VNX001) versus placebo and…
- Trial name
- NCT05737121
- Testing
- VNX001, Lidocaine, Heparin
- Where
- 14 sites in United States
- Volunteers
- 120 people
- Sponsor
- Vaneltix Pharma, Inc.
Interstitial Cystitis, Painful Bladder Syndrome
Amniotic Membrane Therapy for Interstitial Cystitis/Painful Bladder Syndrome
Interstitial cystitis/painful bladder syndrome (IC/PBS) is a clinical syndrome in which patients report symptoms of bladder and/or pelvic pain with pressure and/ or discomfort associated with urinary frequency and urgency.
- Conditions
- Interstitial Cystitis, Painful Bladder Syndrome, Painful Bladder Syndrome (PBS)
- Trial name
- NCT06096597
- Testing
- Clarix Flo
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- David Sheyn
Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction
Urgency, frequency and incomplete emptying are the key symptoms of lower urinary tract dysfunction, including bladder pain syndrome/interstitial cystitis, and overactive bladder syndrome.
- Conditions
- Prostatic Hyperplasia, Urinary Bladder Neck Obstruction, Cystitis, Interstitial
- Trial name
- NCT01482676
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Interstitial Cystitis
Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis
The purpose of this study is to assess the effects of dexmedetomidine while patients undergo treatment for Interstitial Cystitis (IC).
- Trial name
- NCT01195116
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Rochester
Cystitis, Interstitial, Painful Bladder Syndrome
Bladder Directed vs. Pelvic Floor Therapy in IC/BPS
Women with interstitial cystitis/bladder pain syndrome (IC/BPS) have debilitating urinary frequency and urgency, and chronic pelvic or bladder pain perceived to be related to the bladder.
- Trial name
- NCT02870738
- Testing
- Pelvic Floor Physical Therapy, Bladder Instillations
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Corewell Health East
Interstitial Cystitis, Bladder Pain Syndrome, Quality of Life
Quality of Life Analysis in Bladder Pain Syndrome/Interstitial Cystitis
The aim of our study was to evaluate whether there is a higher prevalence of anxiety-depressive disorders in women with interstitial cystitis than in women with chronic non-neoplastic pain with or without fibromyalgia, to examine…
- Trial name
- BPS/IC (NCT05630742)
- Testing
- chronic non-neoplastic pain
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chronic Interstitial Cystitis
The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome (Pilot Study)
This study is to evaluate the efficacy of urine biomarker in patients with interstitial cystitis/painful bladder syndrome
- Trial name
- NCT02331472
- Where
- 2 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Interstitial Cystitis, Painful Bladder Syndrome
Genetics of Interstitial Cystitis
The cause of interstitial cystitis is unknown. However, it tends to run in some families suggesting that there may be a genetic susceptibility to the disease.
- Trial name
- magic (NCT00237081)
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Interstitial Cystitis, Painful Bladder Syndrome
A Randomized Multicenter Double-Blind CT to Evaluate the Efficacy and Safety of Mycophenolate Mofetil . . .
The purpose of this study is to investigate the safety and effectiveness of a medication called CellCept in treating refractory (has not responded to other treatments) interstitial cystitis.
- Trial name
- ICCRN RCT2 (NCT00451867)
- Testing
- Mycophenolate Mofetil, Mycofenolate Mofetil (MMF)
- Where
- 11 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Interstitial Cystitis/Painful Bladder Syndrome, Myofascial Pelvic Pain
Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic Characteristics (ICEPAC) Study
Interstitial cystitis/painful bladder syndrome (IC/PBS) causes severe bladder pain and extensive disability in a large group of women int he prime of their productive lives.
- Trial name
- ICEPAC (NCT01616992)
- Testing
- Bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Uterine Fibroids, Adenomyosis
Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy
The aim of this RCT of study is to compare the standard TLH with adnexal preservation with TLH plus prophylactic bilateral salpingectomy (PBS) in terms of ovarian reserve and surgical outcomes
- Conditions
- Uterine Fibroids, Adenomyosis, Pelvic Pain, Pelvic Prolapse
- Trial name
- NCT02086344
- Testing
- PBS, TLH _adnexal preservation
- Where
- Italy
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Interstitial Cystitis
Therapeutic Effects of Endoscopic Ablation of Hunner Lesions in Interstitial Cystitis/ Bladder Pain Syndrome Patients
efficacy of endoscopic ablation of Hunner lesions in patients with IC/BPS and the characteristics of HLs based on a long-term follow-up
- Trial name
- NCT03468530
- Testing
- Transurethral ablation
- Where
- South Korea
- Volunteers
- 442 people
- Sponsor
- Samsung Medical Center
Interstitial Cystitis, Bladder Pain Syndrome
Comparing the Effect of Fulguration Versus Fulguration and Hydrodistension in Interstitial Cystitis/Bladder Pain Syndrome
This study is a randomized controlled trial. Subject population is adult patients with Hunner-type interstitial cystitis. The objective of this study is to compare the therapeutic effect between the two surgical modality; TUF…
- Trial name
- NCT03987594
- Testing
- Transurethral fulguration of the Hunner lesion, Combination treatment of bladder hydrodistension and transurethral fulguration of the Hunner lesion
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Yonsei University
Chronic Pelvic Pain, Interstitial Cystitis
Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain
We will rigorously test whether modulation of the motor cortex by transcranial direct current stimulation (tDCS) is an effective treatment for patients with chronic pelvic pain through the following specific aims: A) The primary…
- Conditions
- Chronic Pelvic Pain, Interstitial Cystitis, Post Traumatic Stress Disorder, Fibromyalgia
- Trial name
- NCT00554320
- Testing
- tDCS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Summa Health System
Osteoarthritis
Panadol Osteo Pharmaceuticals Benefit Scheme (PBS) Claims Cohort Study
The aim of this observational study is to compare the use of an extended release paracetamol formulation with standard paracetamol in a cohort of Australian concessional patients with osteoarthritis (OA), to assess differences in…
- Trial name
- NCT02262702
- Testing
- Paracetamol 665 mg, Paracetamol 500 mg
- Sponsor
- GlaxoSmithKline
Bladder Pain Syndrome, Pentosan Polysulfate
Efficacy Study of Pentosan Polysulfate Sodium,Hydrodistension and Combination Therapy for Bladder Pain Syndrome
The efficacy of pentosan polysulfate sodium, hydrodistension and combination therapy in patients with bladder pain syndrome.
- Conditions
- Bladder Pain Syndrome, Pentosan Polysulfate, Hydrodistension
- Trial name
- NCT01895153
- Where
- South Korea
- Volunteers
- 91 people
- Sponsor
- Samsung Medical Center
IC - Interstitial Cystitis
Phenotyping Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) by Intravesical Contrast Enhanced - Magnetic Resonance Imaging (ICE-MRI) Bladder Permeability Assay
Each participant will be asked to participate in this research study which distinguishes different types of Interstitial Cystitis/Bladder Pain Syndrome. Research studies include only people who wish to participate.
- Trial name
- NCT05811377
- Testing
- Ferumoxytol, Gadobutrol
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Christopher J Chermansky, MD