Clinical trials: Palliative
HIV (Human Immunodeficiency Virus)
mVIP (Use of mHealth Technology for Supporting Symptom Management in Underserved Persons Living With HIV)
The goal of this study is to facilitate the dissemination and implementation of patient centered outcomes research using mHealth technology to improve self-management of adverse symptoms in persons living with HIV/AIDS (PLWH).
- Trial name
- mVIP (NCT02897141)
- Testing
- Health Management App with symptom strategies, Control App
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Neoplasm Metastasis, Palliative Care
A Study Of Tanezumab as Add-On Therapy to Opioid Medication In Patients With Pain Due To Cancer That Has Spread To Bone
The purpose of this study is to investigate the safety and efficacy of tanezumab in combination with opioids in treating pain due to cancer that has spread to bone.
- Trial name
- NCT00545129
- Testing
- Tanezumab 10 mg IV
- Where
- 39 sites in United States, Austria and 11 more
- Volunteers
- 59 people
- Sponsor
- Pfizer
Breast Cancer
mHealth Behavioral Cancer Pain Intervention for Medically Underserved Patients
The efficacy of a mobile health (mHealth) behavioral cancer pain intervention designed to decrease pain and disability for breast cancer patients in medically underserved areas has not been investigated.
- Trial name
- ICAN-NC (NCT04175639)
- Testing
- Mobile Health Pain Coping Skills Training (mPCST)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Hospice, End of Life
Tandem VR: Synchronized Nature-Based Experiences in Virtual Reality for Hospice Patients and Their Caregivers
Background: Nature-based virtual reality (VR) and other outdoor experiences in head-mounted displays (HMDs) offer powerful, non-pharmacological tools for hospice teams to help patients undergoing end-of-life (EOL) transitions.
- Conditions
- Hospice, End of Life, Palliative Care, Pain
- Trial name
- NCT06186960
- Testing
- Tandem Virtual Reality
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Asthma
Asthma Symptom Management Through Mindfulness Training
Asthma is one of the four most common adult chronic disorders. Supporting asthma patients in improving their asthma control and symptoms as well as their quality of life are important goals in clinical management.
- Trial name
- NCT02275559
- Testing
- Mindfulness Based Stress Reduction (MBSR), Healthy Living Course (HLC)
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Melanoma
Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy
To determine the safety of local palliative radiation therapy used in combination with anti-CTLA-4 immunotherapy.
- Trial name
- NCT01449279
- Testing
- Ipilimumab, Radiation Therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Stanford University
Metastatic Breast Cancer
Phase II PEMBROLIZUMAB + PALLIATIVE RADIOTHERAPY IN BC
This research study is studying radiation therapy in combination with an immunotherapy as a possible treatment for metastatic hormone receptor (HR) positive, HER2-negative breast cancer.
- Trial name
- NCT03051672
- Testing
- Pembrolizumab, Palliative radiotherapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Dana-Farber Cancer Institute
Hepatocellular Carcinoma, Liver Metastases
Study of Palliative Radiotherapy for Symptomatic Hepatocellular Carcinoma and Liver Metastases
The purpose of this study is to see whether one dose of palliative radiation therapy directed to the liver in combination with standard BSC might help to reduce liver pain/discomfort due to cancer when compared to getting…
- Trial name
- NCT02511522
- Testing
- Best Supportive Care, Palliative Radiation Therapy
- Where
- 7 sites in Canada
- Volunteers
- 66 people
- Sponsor
- Canadian Cancer Trials Group
Circulatory Perfusion Disorder, Congenital Heart Disease
Early Use of Vasopressin in Post-Fontan Management
This is an investigator initiated, prospective, single-center, double-blinded, randomized, placebo-controlled trial of post-operative low dose vasopressin infusions as an early treatment of low systemic perfusion in pediatric…
- Conditions
- Circulatory Perfusion Disorder, Congenital Heart Disease, Single-ventricle
- Trial name
- VAMP (NCT03088345)
- Testing
- Vasopressin, Arginine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Pancreatic Cancer, Periampullary Adenocarcinoma
Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma
The investigators are looking to see if a certain dose of stereotactic body radiation therapy (SBRT) may be a viable treatment option for recurrent or residual pancreatic or periampullary adenocarcinoma.
- Trial name
- NCT01781728
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Advance Care Planning, Palliative Care
Palliative Care Educator
The investigators propose to conduct a stepped wedge cluster randomized trial of an advance care planning (ACP) educator-led intervention among hospitalized patients aged 65 and over, or any patient with Alzheimer's Disease and…
- Conditions
- Advance Care Planning, Palliative Care, Alzheimer's Disease and Related Dementias, Doctor-patient Communication
- Trial name
- VIDEO-PCE (NCT04857060)
- Testing
- ACP Educator led, video assisted discussion
- Where
- 2 sites in United States
- Volunteers
- 11,174 people
- Sponsor
- Tufts Medical Center
Dermatologic Complications, Malignant Neoplasm
Menadione Topical Lotion in Treating Skin Discomfort and Psychological Distress in Patients With Cancer Receiving Panitumumab, Erlotinib Hydrochloride, or Cetuximab
This clinical trial studies menadione topical lotion in treating skin discomfort and psychological distress in patients with cancer receiving panitumumab, erlotinib hydrochloride, or cetuximab.
- Conditions
- Dermatologic Complications, Malignant Neoplasm, Pain
- Trial name
- NCT01393821
- Testing
- menadione topical lotion, questionnaire administration, management of therapy complications
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Ageing
Implementation of Knowledge-Based Palliative Care
The research on ageing during the last couple of decades has increasingly focused on questions regarding the quality of life and life satisfaction of the old people.
- Trial name
- KUPA (NCT02708498)
- Testing
- Educational Intervention
- Where
- 30 sites in Sweden
- Volunteers
- 1,151 people
- Sponsor
- Lund University
Cancer, Neoplasm Metastasis
ECI301 and Radiation for Advanced or Metastatic Cancer
Background: ECI301 is a drug that may help make cancer cells more visible to the immune system after radiation. The drug may also help the immune system destroy the cancer at sites that have not received radiation therapy.
- Conditions
- Cancer, Neoplasm Metastasis, Radiation Oncology, Neoplasm
- Trial name
- NCT01441115
- Testing
- Radiation Therapy, ECI301
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Hypertension, Chronic Disease
Urban Zen Integrative Therapy for Persons With Pulmonary Hypertension
The primary goal of this study is to determine the feasibility and acceptability of a 6-week multicomponent integrative therapy program, Urban Zen Integrative Therapy (UZIT), for adults with chronic, life-limiting cardiopulmonary…
- Trial name
- NCT03194438
- Testing
- Urban Zen Integrative Therapy (UZIT)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ohio State University
Prostate Cancer
Prostate Cancer Intervention Versus Observation Trial (PIVOT)
Radical prostatectomy provides potentially curative removal of the cancer. However, it subjects patients to the morbidity and mortality of the surgery and may be neither necessary nor effective.
- Trial name
- PIVOT (NCT00007644)
- Testing
- Radical prostatectomy
- Where
- 31 sites in United States
- Volunteers
- 731 people
- Sponsor
- VA Office of Research and Development
Cancer, Depression
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer
Depression is common in patients with cancer. Current medications for depression, while effective, take several weeks to take effect. Ketamine has emerged as a drug with promise for cancer patients.
- Conditions
- Cancer, Depression, Anxiety
- Trial name
- NCT01680172
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Acquired Immunodeficiency Syndrome (AIDS)
Living Well Project for Persons With AIDS
The overall goal of this project is to implement and test the efficacy of an enhanced comprehensive multidisciplinary early palliative care (EPC) package that includes four motivational interviewing sessions (MI) for persons…
- Trial name
- NCT01848483
- Testing
- AIDS EPC Package plus MI, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Emory University
Liver Cancer, Anxiety Disorder
Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers
The study intervention consists of the early integration of palliative care services into standard oncology care in an outpatient setting for patients with advanced lung and non-colorectal gastrointestinal malignancies who are…
- Conditions
- Liver Cancer, Anxiety Disorder, Depression, Small Cell Lung Cancer
- Trial name
- NCT02349412
- Testing
- Early palliative care
- Where
- 23 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Spinal Metastases
Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases
The purpose of this study is to find out if SBRT is better than CRT at controlling pain in the spine 3 months after receiving treatment.
- Trial name
- NCT02512965
- Testing
- 20 Gy in 5 fractions, Conventional SBRT: 24 Gy in 2 fractions
- Where
- 22 sites in Australia, Canada
- Volunteers
- 229 people
- Sponsor
- Canadian Cancer Trials Group