Clinical trials: Palliative Cancer
Cancer, Depression
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer
Depression is common in patients with cancer. Current medications for depression, while effective, take several weeks to take effect. Ketamine has emerged as a drug with promise for cancer patients.
- Conditions
- Cancer, Depression, Anxiety
- Trial name
- NCT01680172
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Colorectal Neoplasms, Intestinal Neoplasms
Palliative Primary Tumor Resection in Minimally Symptomatic Patients With Colorectal Cancer and Synchronous Unresectable Metastases
Currently, the question remains whether palliative primary tumor resection could improve overall survival of minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases.
- Conditions
- Colorectal Neoplasms, Intestinal Neoplasms, Gastrointestinal Neoplasms, Digestive System Neoplasms
- Trial name
- NCT05322486
- Testing
- surgery of the primary tumour, chemotherapy
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Liver Cancer, Anxiety Disorder
Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers
The study intervention consists of the early integration of palliative care services into standard oncology care in an outpatient setting for patients with advanced lung and non-colorectal gastrointestinal malignancies who are…
- Conditions
- Liver Cancer, Anxiety Disorder, Depression, Small Cell Lung Cancer
- Trial name
- NCT02349412
- Testing
- Early palliative care
- Where
- 23 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Bile Duct Neoplasms
Covered or Uncovered Bile Duct Stents
The study is investigator initiated. Tumors that gives the narrowing of the bile ducts prevents bile from flowing from the liver to the intestine resulting in jaundice and the risk of bacterial growth in bile with severe…
- Trial name
- NCT01232101
- Testing
- covered or uncovered stents
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Göteborg University
Advanced Lung Cancer
A Clinical Study of Pain and Discomfort Associated With Advanced Lung Cancer
In this research, the patients with advanced lung cancer accompanied by pain and discomfort were treated by injecting freshly manufactured tissue permeable hyaluronan fragment HA35 into the tissue under abdominal adipose.
- Trial name
- NCT05852002
- Testing
- 35 kDa hyaluronan fragment
- Where
- Mongolia
- Volunteers
- 10 people
- Sponsor
- Nakhia Impex LLC
Cancer, Venous Thromboembolism
Prophylaxis of Venous Thrombo-Embolism in Cancer Patients Under Palliative Care
To determine the efficacy and to measure the complications of prophylactic anticoagulation using low-molecular weight heparin in adult cancer patients under palliative care
- Trial name
- NCT00303407
- Testing
- nadroparin
- Where
- Switzerland
- Sponsor
- University Hospital, Geneva
Esophageal Cancer
Liposomal iRInotecan, Carboplatin or oXaliplatin for Esophagogastric Cancer
This is a multi-center, open label, randomized phase II trial for patients with previously untreated metastatic or locally advanced esophagogastric cancer, using a pick the winner design to identify the best combination therapy…
- Trial name
- LyRICX (NCT03764553)
- Testing
- Liposomal Irinotecan, Carboplatin, Capecitabine
- Where
- 34 sites in Netherlands
- Volunteers
- 320 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Palliative Care
Palliative Short Course Radiotherapy for Advanced Thoracic Cancer
The study wants to define the maximum tolerated dose (MTD), safety and efficacy of a short course radiation therapy in patients with symptomatic advanced thoracic cancer.
- Trial name
- NCT03465553
- Testing
- Short course radiotherapy
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Obstructive Pulmonary Disease, Metastatic Cancer
Improving End-of-life Care by Continuing Medical Education and Electronic Decision Making Support for General Practitioners
Background: Optimizing the basic palliative care has been shown beneficial to patients in end-of-life care, the general practitioner (GP) having a pivotal role in the health care system, providing comprehensive and continued…
- Trial name
- NCT02050256
- Testing
- continuing medical education and electronic decision support, education and electronic support
- Where
- Denmark
- Sponsor
- University of Aarhus
Pain
Coaching to Improve Care of Cancer Pain
An estimate of 90% of patients with cancer experience at least moderate pain at some point in their illness, and 42% of patients do not receive adequate palliation.
- Trial name
- NCT00283166
- Testing
- Tailored Education and Coaching
- Where
- 3 sites in United States
- Volunteers
- 258 people
- Sponsor
- University of California, Davis
Cholangiocarcinoma, Biliary Stricture
Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma
Successful palliation of biliary obstruction is the main goal for reducing morbidity and mortality in patients with biliary disease and biliary obstruction related to cholangiocarcinoma.
- Conditions
- Cholangiocarcinoma, Biliary Stricture, Biliary Obstruction, Bile Duct Cancer
- Trial name
- NCT01755013
- Testing
- Photodynamic Therapy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Weill Medical College of Cornell University
Advanced Breast Cancer
Acceptability and Feasibility of PSC Model of Serious Illness Communication
This prospective, single-arm pilot study evaluates the feasibility and acceptability of a novel Patient Support Coordinator (PSC) model for women with advanced or high-risk breast cancer in an outpatient oncology setting.
- Trial name
- NCT07428655
- Testing
- PSC-facilitated supportive listening
- Where
- Singapore
- Volunteers
- 28 people
- Sponsor
- National Cancer Centre, Singapore
Breast Cancer, Chemotherapy Side Effects
Artificial Intelligence-supported Mobile Application for Patients With Breast Cancer
This randomized controlled clinical trial aims to evaluate the effects of an artificial intelligence-supported mobile application on symptom management, self-efficacy, and quality of life in breast cancer patients receiving…
- Trial name
- NCT07826338
- Testing
- AI-Supported Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ege University
Breast Cancer
Home-Based Symptom Management Via Reflexology for Breast Cancer Patients
The purpose of this project is to test foot reflexology delivered by a friend or family member in the home for women with breast cancer.
- Trial name
- NCT01582971
- Testing
- Reflexology
- Where
- 9 sites in United States
- Volunteers
- 256 people
- Sponsor
- Michigan State University
Breast Cancer, Palliative Care
The Impact of SPC on Advanced Breast Cancer Patients
The aim of this prospective, observational study is the evaluation of the effectiveness of a 14-day Specialist Palliative Care therapy in participants with advanced breast cancer carried out in a stationary palliative care unit…
- Conditions
- Breast Cancer, Palliative Care, Quality of Life, Cancer, Breast
- Trial name
- NCT03612934
- Testing
- Specialist Palliative Care
- Volunteers
- 144 people
- Sponsor
- Silesian University of Medicine
Cancer
Metronomic Chemotherapy by Cyclophosphamide Versus Megestrol in Palliative Cancer
The scope of the trial is to assess the free progression rate at 2 months for each group of patients.
- Trial name
- PALANGI (NCT00420563)
- Testing
- CYCLOPHOSPHAMIDE, MEGESTROL
- Where
- 4 sites in France
- Volunteers
- 88 people
- Sponsor
- Centre Oscar Lambret
Breast Neoplasms
Behavioral Symptom Management Program for Breast Cancer in Singapore and The US
Research indicates that up to two-thirds of patients with advanced cancer experience significant symptom burden (e.g., anxiety and depression, pain, fatigue), yet these symptoms are not adequately addressed.
- Trial name
- NCT02865148
- Testing
- Cognitive behavioral therapy
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Duke-NUS Graduate Medical School
Mesothelioma, Malignant
Malignant Mesothelioma - Can we Improve Quality of Life
Patients with malignant pleural mesothelioma (MPM) frequently have significant physical symptoms, with up to 92% of patients complaining of three or more symptoms at presentation.
- Trial name
- RESPECT-Meso (NCT03068117)
- Testing
- Regular Early Specialist Symptom Control Treatment (RESSCT)
- Where
- 19 sites in Australia, United Kingdom
- Volunteers
- 319 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Cancer
Spiritual Care or Psychotherapy Versus Palliative Care Alone in Patients With Non-Curative Malignancies
This phase III clinical trial will evaluate the impact on survival of adding chaplain-provided spiritual care or psychotherapy/meditation to standard-of-care (SOC) and palliative measures, plus chemotherapy if recommended, and…
- Trial name
- SPC (NCT07290491)
- Testing
- Chaplain-Provided Spiritual Care, Psychotherapy and Meditation Intervention
- Where
- United States
- Volunteers
- 854 people
- Sponsor
- The Methodist Hospital Research Institute
Squamous Cell Carcinoma of the Head and Neck
A Study of the Combination of Cetuximab and Methotrexate in Recurrent or Metastatic Cancer of the Head and Neck
The investigators will perform a randomized phase II study to investigate if the addition of cetuximab to MTX is beneficial for the patient.
- Trial name
- COMMENCE (NCT02054442)
- Testing
- Cetuximab, Methotrexate
- Where
- 8 sites in Netherlands
- Volunteers
- 52 people
- Sponsor
- Radboud University Medical Center
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