Clinical trials: Palliative Cancer, open to volunteers
Palliative Care, Advanced Cancer
A Feasibility Study of Death Education Intervention for Family Caregivers of Advanced Cancer Patients
Advanced cancer is the leading cause of death in the world and China. Family caregivers, as the closest individuals to advanced cancer patients, suffer from a range of psychological and spiritual issues due to patients' impending…
- Conditions
- Palliative Care, Advanced Cancer, Family Caregivers
- Trial name
- NCT07367984
- Testing
- Death education intervention for family caregivers of advanced cancer patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Lung Cancers
An Evaluation of Dose-escalation for Intrathoracic Tumours
This is a pragmatic trial with patients randomized between standard of care palliative thoracic radiation therapy (RT) vs. hypofractionated, dose-escalated, esophageal-sparing (HD-ES) intensity modulated radiation therapy (IMRT).
- Trial name
- PREVENT-LUNG (NCT06794125)
- Testing
- Hypofractionated Radiation Therapy, Radiation Therapy
- Where
- 4 sites in Canada
- Volunteers
- 141 people
- Sponsor
- Chris Goodman
Peritoneal Carcinomatosis
Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors
This single-center, Phase 1 dose-escalation study will evaluate the safety, tolerability, and recommended Phase 2 dose (RP2D) of pressurized intraperitoneal aerosol chemotherapy with mitomycin C (PIPAC-MMC) for patients with…
- Trial name
- NCT07487168
- Testing
- Mitomycin C (MMC), Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hematologic Malignancy, Blood Cancer
Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy
The goal of this study is to determine whether a palliative care intervention (PEACE) can improve the quality of life and experiences of participants with Lymphoma, Leukemia, or Multiple Myeloma receiving adoptive cellular…
- Conditions
- Hematologic Malignancy, Blood Cancer, Lymphoma, Leukemia
- Trial name
- PEACE (NCT05646576)
- Testing
- Palliative Care, Usual Care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Advanced Cancer
Care Coach-led Integrated Palliative Surgical Oncology and Rehabilitation Care Model for Advanced Cancer Patients
Advanced cancer is a life-limiting condition that can negatively impact quality of life and function. Patients often suffer from physical, emotional, social, spiritual, and decision-making issues.
- Trial name
- NCT07133269
- Testing
- Care Coach-led Palliative Surgical Oncology (PSO), Rehabilitation
- Where
- 2 sites in Singapore
- Volunteers
- 770 people
- Sponsor
- Singapore General Hospital
Gynecological Oncology, Gynecology
Yoga in Women With Surgical Menopause After Gynecological Cancer
This randomized controlled trial investigates the effects of yoga on quality of life, sleep quality, and spiritual well-being in women who have entered surgical menopause after gynecological cancer surgery.
- Conditions
- Gynecological Oncology, Gynecology, Oncology, Surgical Menopause
- Trial name
- NCT07141953
- Testing
- Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Dokuz Eylul University
Gynaecological Cancer
Palliation in Gynae-oncology: Patients Expectations and Assessment of Care (PEACE)
The overall aim is to assess the feasibility and acceptability of collecting data on the patients and carers perception of care as well as to prospectively monitor end of life care.
- Trial name
- PEACE (NCT05142150)
- Testing
- Questionaire
- Where
- Norway
- Volunteers
- 73 people
- Sponsor
- Nordic Society of Gynaecological Oncology - Clinical Trials Unit
Older Patients, Colorectal Cancer
DOSAGE Study: Upfront Dose-Reduced Chemotherapy in Older Patients with Metastatic Colorectal Cancer
The goal of this phase III, open-label, non-inferiority randomized controlled clinical trial is compare upfront dose-reduced chemotherapy with the standard dose chemotherapy in older patients ( ≥70 years) with metastasized…
- Conditions
- Older Patients, Colorectal Cancer, Metastatic Cancer, Candidates for Palliative Chemotherapy
- Trial name
- DOSAGE (NCT06275958)
- Testing
- Doublet Chemotherapy, Standard Dose (100%), Doublet Chemotherapy, Dose-reduced (75%), Monotherapy, Standard Dose (100%)
- Where
- 36 sites in Netherlands
- Volunteers
- 587 people
- Sponsor
- Leiden University Medical Center
Malignancy-induced Pelvic Pain
CT-guided Pudendal Nerve Cryoneurolysis for Palliation of Malignancy-induced Pelvic Pain
We want to study if a new treatment called "CT-guided bilateral pudendal nerve cryoneurolysis" can help people with severe and long-lasting pain in the pelvic area caused by cancer.
- Trial name
- NCT06110065
- Testing
- CT-guided Pudendal Nerve Cryoneurolysis, Percutaneous image-guided cryoneurolysis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arizona
Metastatic Gastric Cancer, Surgery
Clinical Outcome of Palliative Surgery After Translational Therapy for Metastatic Gastric Cancer Versus Maintenance Chemotherapy for Metastatic Gastric Cancer
This single-center, prospective study was conducted to investigate the efficacy and safety of palliative surgery after translational therapy in the treatment of metastatic gastric cancer.
- Conditions
- Metastatic Gastric Cancer, Surgery, Chemotherapy
- Trial name
- NCT05230771
- Testing
- Palliative surgery after translational therapy, Chemotheraoy along
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Ovarian Cancer, Endometrial Cancer
Registry Platform Ovarian and Endometrial Cancer
The purpose of the project is to set up a national, prospective, longitudinal, multicenter cohort study, a tumor registry platform, to document uniform data on characteristics, molecular diagnostics, treatment and course of…
- Conditions
- Ovarian Cancer, Endometrial Cancer, Ovary Neoplasm, Endometrial Neoplasms
- Trial name
- SMARAGD (NCT05129969)
- Testing
- Physician's choice according to patient's needs.
- Where
- Germany
- Volunteers
- 1,975 people
- Sponsor
- iOMEDICO AG
GI Cancer
Effect of Geriatric Intervention in Frail Patients with Gastric, Biliary, and Pancreatic Cancer Receiving Palliative Chemotherapy
Gastric, biliary and pancreatic cancer are commonly malignancies from gastro- intestinal tract in Taiwan. Because lack of specific symptoms at presentation and effective screening methodology, majority of these patients are…
- Trial name
- NCT06040801
- Testing
- Frailty intervention measures
- Where
- Taiwan
- Volunteers
- 138 people
- Sponsor
- Chang Gung Memorial Hospital
Triple Negative Breast Cancer, Uterine Cervical Cancer
Immune PET and Proteomics for the Assessment of Response to Spatially Fractionated or Palliative Radiotherapy With or Without Immunotherapy
The aim of the study is to evaluate the response to four schemes of treatment with novel diagnostic tools - Immuno-PET and proteomics as well as standard imaging (magnetic resonsonce imaging and computed tomography).
- Conditions
- Triple Negative Breast Cancer, Uterine Cervical Cancer, Uterine Corpus Cancer, Malignant Melanoma
- Trial name
- INTROSPECTION (NCT06976021)
- Testing
- Baseline 89-Zr Pembrolizumab Immuno PET-CT, Proteomic assay, Follow-up 89-Zr Pembrolizumab Immuno PET-CT
- Volunteers
- 60 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Palliative Radiotherapy, Metastatic Cancer (Different Solid Tumour Types)
Hybrid Arc Palliative Radiation Therapy (HART): A Single Arm Phase II Trial
This is a prospective single-center single-arm Phase II trial of HART for patients with metastatic cancer. The primary objective is to assess the incidence of acute GI toxicity following HART.
- Trial name
- HART (NCT06778408)
- Testing
- Hybrid Palliative Radiation Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Vermont Medical Center
Esophageal Cancer
Chemoradiotherapy for Advanced Esophageal Cancer
This study aims to show that the addition of carboplatin and paclitaxel chemotherapy to a palliative course of external beam radiation treatment improves both dysphagia relief and patient quality of life in patients with…
- Trial name
- PaRCUS (NCT02297217)
- Testing
- Carboplatin and Taxol (paclitaxel), External Beam Radiation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- AHS Cancer Control Alberta
Health Literacy, Prostate Cancer
Cancer Literacy Education and Awareness Resources for Prostate Care
The CLEAR-PC project addresses the critical issue of low health literacy in prostate cancer prevention and care, recognising that inadequate health literacy leads to difficulties in understanding complex medical information…
- Trial name
- CLEAR-PC (NCT07437482)
- Testing
- Co-created digital health literacy intervention for prostate cancer prevention and care
- Where
- Spain
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Pediatric Cancer
Nurse-led Transitional Care to Improve Symptom Management in Childhood Cancer Survivors
This study aims to evaluate the feasibility and preliminary effectiveness of a nurse-facilitated interdisciplinary transitional care programme, based on the Omaha system, for Chinese childhood cancer survivors (CCSs) and their…
- Trial name
- NCT07273682
- Testing
- Counseling based on Omaha system, Usual Care
- Volunteers
- 68 people
- Sponsor
- The Hong Kong Polytechnic University
Palliative Care, Acute Myeloid Leukaemia
Effectiveness of Early Intervention in Palliative Care for Acute Myeloid Leukemia Patients Comparing to Standard of Care
Hemato-oncology patients undergoing intensive chemotherapy treatments experience different types of symptoms during and after treatments, which are often refractory to the established therapy.
- Trial name
- NCT06848270
- Testing
- Early palliative care integration
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Caregiver Burden, Caregiver Burnout
A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer
Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers/MCP-C or standard Supportive Psychotherapy for Caregivers/SP-C sessions.
- Conditions
- Caregiver Burden, Caregiver Burnout, Caregiver Stress Syndrome
- Trial name
- NCT06307535
- Testing
- Meaning-Centered Psychotherapy for Caregivers, Supportive Psychotherapy for Caregivers
- Where
- 8 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cancer Pain, Erector Spinae Plane Block
Intermittent Erector Spinae Plane Block Via Subcutaneous Port for Cancer Pain
Cancer-related pain is a common and challenging problem in patients with lung cancer, often requiring long-term pain management.
- Trial name
- NCT07396558
- Testing
- Erector Spinae Plane Block
- Where
- Vietnam
- Volunteers
- 180 people
- Sponsor
- Hanoi Medical University