Clinical trials: Palliative Care, Patient Care
Critical Illness
Feasibility Study on Implementing Consultation-based High-quality Palliative Care Services in Intensive Care Units
Critically ill patients in intensive care units (ICUs) receive life-sustaining treatments aimed at restoring or maintaining organ function.
- Trial name
- NCT06490835
- Testing
- High-quality palliative care through consultation-based palliative care services in the ICU
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm
- Trial name
- PICSI-H (NCT04281784)
- Testing
- EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 2,512 people
- Sponsor
- University of Washington
Hormone Receptor Positive HER-2 Negative Breast Cancer, Advanced or Metastatic Breast Cancer
Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer
Trial design: Phase II, prospective, multi-center, randomized, open label, parallel group study in patients with HR-positive, HER2-negative locally advanced or metastatic breast cancer with gBRCA1/2 mutation, with 2:1…
- Conditions
- Hormone Receptor Positive HER-2 Negative Breast Cancer, Advanced or Metastatic Breast Cancer, BRCA1 Mutation, BRCA2 Mutation
- Trial name
- ELEMENT (NCT06201234)
- Testing
- Olaparib + Elacestrant, Olaparib
- Where
- 36 sites in Germany
- Volunteers
- 176 people
- Sponsor
- GBG Forschungs GmbH
Cancer
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study
The purpose of this feasibility study is to inform a larger randomized, placebo-controlled, double blind, parallel-group, single-centre trial of an oral, daily administered single dose of melatonin to prevent delirium in patients…
- Trial name
- NCT02200172
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Bruyère Health Research Institute.
Advanced Malignant Neoplasm, Delirium
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
This randomized phase II/III trial studies how well haloperidol with or without chlorpromazine works in treating delirium in patients with cancer that has spread to other parts of the body or has come back.
- Conditions
- Advanced Malignant Neoplasm, Delirium, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm
- Trial name
- NCT03021486
- Testing
- Chlorpromazine, Haloperidol, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer
Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
RATIONALE: Palliative care may help patients with advanced cancer live more comfortably. PURPOSE: This randomized clinical trial is studying an early intervention palliative care program to see how well it works compared to a…
- Trial name
- NCT00253383
- Testing
- counseling intervention, educational intervention, psychosocial assessment and care
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cancer, Suffering
The Immediate Effect of Mindfulness-Based Supportive Therapy on Palliating Suffering in Palliative Care Cancer Patients
The was a parallel group, single-blinded, randomized controlled trial comparing the effectiveness of 30-minute mindfulness-based supportive therapy versus supportive listening in reducing suffering among patients with cancer.
- Trial name
- NCT05010239
- Testing
- 30-minute Mindfulness-Based Supportive Therapy, 30-minute supportive listening
- Where
- Malaysia
- Volunteers
- 68 people
- Sponsor
- University Malaysia Sarawak
Palliative Care
Palliative Care For Me (PCforMe)
The purpose of this study is to test the usability of PCforMe, a web-based preparation and engagement tool about palliative care, during a pre-visit pilot trial in outpatient palliative care at the Duke Cancer Institute…
- Trial name
- NCT03874195
- Testing
- Access to PCforMe for review, Access to three nationally-recognized Palliative Care websites for review
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Early Palliative Care for Patients With Haematological Malignancies
Patients suffering from haematological disease present symptoms of discomfort and currently benefit from palliative care skills only for the management of their end-of-life.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome, Diffuse Large B Cell Lymphoma, Palliative Care
- Trial name
- CALVI (NCT03800095)
- Testing
- Early palliative care integration
- Where
- 6 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Palliative Care
A Prospective, Open Label, Pilot Study of Patient OutcoMes Following Successful TriAl of High Frequency SpInal CorD Stimulation at 10kHz (HF10™) Leading to Permanent Implant Compared to Trial Failure and Standard CarE for the TreatmeNt of Persistent Low BACK Pain of Neuropathic Origin
25 participants with back pain and no previous spinal surgery will be enrolled from a single NHS site in England. Participants will have already discussed spinal cord stimulation (SCS) pain management with their consultant before…
- Trial name
- Maiden Back (NCT02689375)
- Testing
- Senza Spinal Cord Stimulation system
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Chronic Heart Failure
Integrated Cardiac Care and Palliative Homecare for Patients With Severe Heart Failure
Patients with severe heart failure have as many symptoms as many patients with cancer but yet do not have equal access to supportive and palliative care.
- Trial name
- NCT01304381
- Testing
- Integrated care
- Where
- Sweden
- Volunteers
- 72 people
- Sponsor
- Umeå University
HIV
Outcomes for Antiretroviral Therapy Patients Receiving Palliative Care
Despite overwhelming need for effective HIV palliative care in sub-Saharan Africa, a systematic appraisal of the literature found almost no outcome or evaluative evidence.
- Trial name
- TOPCare (NCT01608802)
- Testing
- Palliative care, Standard care
- Where
- 2 sites in Kenya, South Africa
- Volunteers
- 240 people
- Sponsor
- King's College London
Advanced Cancer
A Primary Palliative Care Intervention for Patients With Advanced Cancer
The overall goal of this study is to test whether a nurse-led intervention to improve provision of primary palliative care within oncology practices (CONNECT) can decrease morbidity for patients with advanced cancer and their…
- Trial name
- CONNECT (NCT02712229)
- Testing
- CONNECT
- Where
- United States
- Volunteers
- 1,290 people
- Sponsor
- University of Pittsburgh
Lung Cancer, Non-small Cell Lung Cancer
Prospective Study to Determine Impact of Early Palliative Care Consult on Quality of Life (QOL), Cancer Related Symptoms In Advanced Lung Cancer Patients: Thoracic Pilot Project
The goal of this study is to learn about the quality of life (QOL) in participants with advanced lung cancer.
- Trial name
- NCT02459002
- Testing
- QOL Questionnaire, Caregiver Satisfaction Questionnaire
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Neoplasms of Independent (Primary) Multiple Sites
Difference in the Estimation of Prognosis
Objectives: Primary Objective: The primary objective is to identify the difference in the estimation of prognosis of advanced cancer patients between medical oncologists, gynecological oncologists, and palliative care physicians
- Trial name
- NCT03115528
- Testing
- Estimation of Prognosis Questionnaire
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Stroke
Turkish Validity and Reliability of the Expanded Rehabilitation Complexity Scale
The RCS is a tool that can assess the need for complex rehabilitation and objectively indicate that a patient may have difficulty functioning well at home or in the community if their medical needs are still high.
- Trial name
- NCT06573359
- Testing
- questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Cancer-Related Pain
The Effectiveness of Progressive Muscle Relaxation Technique in Reducing Cancer-related Pain
This randomized controlled trial was designed to evaluate the effectiveness of the Progressive Muscle Relaxation (PMR) technique in reducing Cancer-related Pain (CRP) in patients receiving palliative care in Jordan.
- Trial name
- NCT04436705
- Testing
- Progressive Muscle Relaxation (PMR) technique
- Volunteers
- 148 people
- Sponsor
- University of Jordan
Leukemia, Acute, AML, Adult
Palliative Care Oncology in Patients With Relapsed, Refractory, and High-Risk Leukemias or MDS
The purpose of this study is to estimate the potential benefit of early and continued palliative care (PC) consultation on end of life issues.
- Conditions
- Leukemia, Acute, AML, Adult, ALL, Adult, Myelodysplastic Syndromes
- Trial name
- NCT04482894
- Testing
- Palliative Care Visits
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Virginia
Spinal Muscular Atrophy 1
Palliative Care in Spinal Muscular Atrophy (SMA) 1
The purpose of this study is to evaluate the quality of supportive and palliative care for SMA type 1 patients.
- Trial name
- ASI1 (NCT01862042)
- Testing
- Follow-up diary and questionnaire
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Advanced Cancer, Neoplasms
The "Hand-in-Hand Study": Improvement of Quality of Life in Palliative Cancer Patients Through Collaborative Advance Care Planning
This study evaluates the effect of a collaborative advance care planning intervention on the quality of life in palliative oncological patients.
- Conditions
- Advanced Cancer, Neoplasms, End Stage Cancer
- Trial name
- COLAP (NCT03387436)
- Testing
- Study-Intervention
- Where
- 2 sites in Germany
- Volunteers
- 280 people
- Sponsor
- PD. Dr. med. Carola Seifart