Clinical trials: Palliative Care
Acute Myeloid Leukemia
RN-Led Palliative and Supportive Care Intervention
This single institution feasibility and acceptability study includes patients with acute leukemia which is designed to examine a novel palliative and supportive care intervention (Palliative and supportive Care inTervention…
- Trial name
- NCT04570709
- Testing
- Palliative And supportive Care inTervention (PACT)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Circulatory Perfusion Disorder, Congenital Heart Disease
Early Use of Vasopressin in Post-Fontan Management
This is an investigator initiated, prospective, single-center, double-blinded, randomized, placebo-controlled trial of post-operative low dose vasopressin infusions as an early treatment of low systemic perfusion in pediatric…
- Conditions
- Circulatory Perfusion Disorder, Congenital Heart Disease, Single-ventricle
- Trial name
- VAMP (NCT03088345)
- Testing
- Vasopressin, Arginine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Advanced Malignant Neoplasm, Delirium
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
This randomized phase II/III trial studies how well haloperidol with or without chlorpromazine works in treating delirium in patients with cancer that has spread to other parts of the body or has come back.
- Conditions
- Advanced Malignant Neoplasm, Delirium, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm
- Trial name
- NCT03021486
- Testing
- Chlorpromazine, Haloperidol, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Sarcoma, Thoracic Cancer
Palliative Lattice Stereotactic Body Radiotherapy (SBRT) for Patients With Sarcoma, Thoracic, Abdominal, and Pelvic Cancers
This is a study evaluating the safety and efficacy of Lattice SBRT for patients with large tumors (≥ 4.5 cm) planning to undergo palliative radiotherapy.
- Conditions
- Sarcoma, Thoracic Cancer, Abdominal Cancer, Pelvic Cancer
- Trial name
- NCT04553471
- Testing
- Stereotactic body radiotherapy, Research blood draw
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Non-Small Cell Lung Cancer (NSCLC)
Vorinostat in Combination With Palliative Radiotherapy for Patients With Non-Small Cell Lung Cancer
This is a dose escalation study that will assess the safety of Vorinostat, a Histone Deacetylase (HDAC) inhibitor, in combination with palliative radiotherapy in patients with advanced or metastatic Non-Small Cell Lung Cancer…
- Trial name
- NCT00821951
- Testing
- Vorinostat, Radiotherapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Hospice, End of Life
Tandem VR: Synchronized Nature-Based Experiences in Virtual Reality for Hospice Patients and Their Caregivers
Background: Nature-based virtual reality (VR) and other outdoor experiences in head-mounted displays (HMDs) offer powerful, non-pharmacological tools for hospice teams to help patients undergoing end-of-life (EOL) transitions.
- Conditions
- Hospice, End of Life, Palliative Care, Pain
- Trial name
- NCT06186960
- Testing
- Tandem Virtual Reality
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Kidney Failure, Chronic
Advance Care Planning With Older Patients Who Have End-stage Kidney Disease
This study will test the feasibility of carrying out a randomised controlled trial, incorporating a mixed methods process evaluation, to evaluate advance care planning with older patients who have end-stage kidney disease.
- Trial name
- ACREDiT (NCT02631200)
- Testing
- Advance care plan
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Queen's University, Belfast
Pain, Cancer
Study to Compare the Safety and Tolerability of Sativex® in Patients With Cancer Related Pain
The purpose of this study is to assess the safety and tolerability of long term therapy with Sativex® and GW-2000-02.
- Trial name
- NCT00675948
- Testing
- Sativex, GW-2000-02
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Jazz Pharmaceuticals
Fallopian Tube Cancer, Ovarian Sarcoma
Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies
RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. PURPOSE: This clinical trial studies stereotactic radiosurgery using CyberKnife works in treating women with…
- Conditions
- Fallopian Tube Cancer, Ovarian Sarcoma, Ovarian Stromal Cancer, Recurrent Cervical Cancer
- Trial name
- NCT01079832
- Testing
- stereotactic radiosurgery, quality-of-life assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Comprehensive Cancer Center
Bone Metastases
Lazanda in Cancer Patients Receiving Palliative Radiation
Advanced cancer patients often require palliative (pain relieving) radiotherapy to treat cancer-related symptoms. The delivery of radiation requires patients to lie still on a hard flat surface, which can result in significant…
- Trial name
- NCT03071744
- Testing
- Lazanda
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Joseph Ma
Critical Illness, Family Members
Addressing Palliative Care Needs Among Intensive Care Unit Family Members
The quality of palliative care is highly variable for many patients treated in intensive care units (ICUs) and their family members.
- Conditions
- Critical Illness, Family Members, Psychological Distress, Informal Caregivers
- Trial name
- ICUconnect (NCT03506438)
- Testing
- Needs-focused mobile app, Usual care
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Duke University
Alzheimer Disease, Dementia
Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)
The purpose of this study was to determine whether a low dose an opiate pain medication is effective for the treatment of discomfort in patients with advanced dementia.
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Pain
- Trial name
- LDOT (NCT00385684)
- Testing
- hydrocodone/APAP
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm
- Trial name
- PICSI-H (NCT04281784)
- Testing
- EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 2,512 people
- Sponsor
- University of Washington
Stem Cell Transplant
Inpatient Palliative Care for Patients Undergoing Hematopoietic Stem Cell Transplantation
This research study is evaluating the impact of early involvement of a palliative care team working with the transplant oncology team will have on the quality of life, symptoms, and mood of patients undergoing stem cell…
- Trial name
- NCT03641378
- Testing
- Palliative Care Intervention, Standard Transplant Care
- Where
- 3 sites in United States
- Volunteers
- 546 people
- Sponsor
- Massachusetts General Hospital
Cancer
Behavioral Nudges to Improve Palliative Care Utilization in Advanced Cancer
Patients with cancer often undergo costly therapy and acute care utilization that is discordant with their wishes, particularly at the end of life.
- Trial name
- BE-EPiC (NCT05365997)
- Testing
- Default Nudge
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Monitoring, Immunologic
Immunosurveillance for Metastatic Colorectal Cancer
The goal of this clinical trial is to learn if adding sodium nucleinate to FOLFOX chemotherapy helps people with metastatic colorectal cancer (colon or rectal cancer that has spread).
- Trial name
- ISMCC (NCT06509880)
- Testing
- Adenorine, FOLFOX regimen
- Where
- Kazakhstan
- Volunteers
- 187 people
- Sponsor
- MIPO Clinic
Palliative Care
Improving Palliative Care Through Teamwork
One in three Americans dies in a nursing home (NH) or in a hospital, shortly following transfer from a long-term care facility. The proportion of deaths occurring in NHs is projected to increase to 40% by 2020.
- Trial name
- IMPACTT (NCT01990742)
- Testing
- Palliative Care Team (PCTeam)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Rochester
Cancer, Fatigue
Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer
BACKGROUND: Patients with advanced cancer often suffer from fatigue and other symptoms and problems such as insomnia, appetite loss and pain. Problems that may have great consequences for their quality of life.
- Trial name
- NCT00925899
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Colorectal Cancer Metastatic
Study of Durvalumab and Tremelimumab After Radiation for Microsatellite Stable Metastatic Colorectal Cancer Progressing on Chemotherapy
This study is being done to look at the safety and response to the combination of two investigational drugs, tremelimumab and durvalumab, when given after radiation therapy for patients with microsatellite stable (MSS) metastatic…
- Trial name
- NCT03007407
- Testing
- durvalumab, Tremelimumab
- Where
- 18 sites in United States
- Volunteers
- 33 people
- Sponsor
- NSABP Foundation Inc
Cancer, Depression
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer
Depression is common in patients with cancer. Current medications for depression, while effective, take several weeks to take effect. Ketamine has emerged as a drug with promise for cancer patients.
- Conditions
- Cancer, Depression, Anxiety
- Trial name
- NCT01680172
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic