Clinical trials: Palliative Patients
Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer
Improving Informed Consent for Palliative Chemotherapy
Patients are routinely asked to sign an "informed consent" document prior to starting chemotherapy, indicating they understand the risks and benefits of treatment.
- Conditions
- Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer
- Trial name
- NCT02282722
- Testing
- Investigational informed consent for chemotherapy, Usual, standard-of-care informed consent for chemotherapy
- Where
- 8 sites in United States
- Volunteers
- 216 people
- Sponsor
- Dana-Farber Cancer Institute
Head and Neck Cancer
Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma
This trial will evaluate safety and efficacy of the combination of anti-PD1, NKTR-214, and palliative radiation therapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
- Trial name
- NCT04936841
- Testing
- NKTR-214, anti-PD-1 therapy, Palliative Radiation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Wisconsin, Madison
Cancer, Thoracic Neoplasms
Improving Cancer On-treatment Symptom Management
Patient-reported outcome measures (PROMs) is an umbrella term that refers to any report on a health status measure that is reported directly by the patient, without the influence of clinicians or anyone else.
- Conditions
- Cancer, Thoracic Neoplasms, Gastrointestinal Cancer, Lung Cancer
- Trial name
- IMPROVE (NCT04589247)
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Sarcoma, Thoracic Cancer
Palliative Lattice Stereotactic Body Radiotherapy (SBRT) for Patients With Sarcoma, Thoracic, Abdominal, and Pelvic Cancers
This is a study evaluating the safety and efficacy of Lattice SBRT for patients with large tumors (≥ 4.5 cm) planning to undergo palliative radiotherapy.
- Conditions
- Sarcoma, Thoracic Cancer, Abdominal Cancer, Pelvic Cancer
- Trial name
- NCT04553471
- Testing
- Stereotactic body radiotherapy, Research blood draw
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Head and Neck Cancer
Docetaxel, Cisplatin, and Cetuximab (TPC) in Palliative Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Docetaxel and cetuximab are FDA-approved for the treatment of squamous cell carcinoma of the head and neck (SCCHN). Cisplatin and carboplatin, while not FDA-approved for SCCHN, have been used as standard of care in SCCHN patients…
- Trial name
- NCT01437449
- Testing
- Docetaxel, Cisplatin, Cetuximab
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
Cancer, Fatigue
Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer
BACKGROUND: Patients with advanced cancer often suffer from fatigue and other symptoms and problems such as insomnia, appetite loss and pain. Problems that may have great consequences for their quality of life.
- Trial name
- NCT00925899
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Squamous Cell Head and Neck Carcinoma, Recurrent or Metastatic Disease
Chemotherapy With Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
PURPOSE: Cetuximab with platinum and 5FU is now the standard combination as first-line treatment in patients with metastatic or recurrent Head and Neck squamous cell carcinomas.
- Trial name
- TPEx (NCT01289522)
- Testing
- cetuximab IV, Biopsies
- Where
- 14 sites in Belgium, France
- Volunteers
- 54 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Hospices, Poly Pharmacy
Standardized Patient-Centered Medication Review in Home Hospice
This is a pilot cluster randomized trial that tests the effect of a novel intervention that trains hospice staff to 1. regularly review, simplify, and align patients' prescribed medications with their goals of care as their…
- Conditions
- Hospices, Poly Pharmacy, Deprescriptions, Caregivers
- Trial name
- SPECTORx (NCT03972163)
- Testing
- NIA Medication Management - Active Comparator, STOPPFrail (Screening Tool of Older Persons Prescriptions), "Discontinuing Medication Appropriately" and "Understanding the Art of Communication about Deprescribing"
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Massachusetts, Worcester
Parkinson's Disease
Does Outpatient Palliative Care Improve Patient-centered Outcomes in Parkinson's Disease?
The purpose of this study is to improve outcomes for persons living with Parkinson's Disease (PD) and their family caregivers. The investigators hypothesize that outpatient interdisciplinary palliative care will improve…
- Trial name
- NCT02533921
- Testing
- Interdisciplinary outpatient palliative care, Standard of Care
- Where
- 3 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- University of Colorado, Denver
Lung Cancer, Medication Adherence
Implementation Strategies for Monitoring Adherence in Real Time
The objective of this project is to identify effective strategies to help patients with lung cancer manage side effects and achieve optimal adherence to oral targeted therapies.
- Conditions
- Lung Cancer, Medication Adherence, Symptoms and Signs
- Trial name
- iSMART (NCT04347161)
- Testing
- Conversational Agent/Chatbot, Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung Cancer
Supportive Care for Patients Newly Diagnosed With Lung Cancer
The aims of this project are to assess the feasibility of recruiting patients and delivering a nurse-led telephone based palliative care intervention for patients with newly diagnosed lung cancer and to assess if among patients…
- Trial name
- NCT01883986
- Testing
- Palliative Care
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- VA Office of Research and Development
Gastric Cancer
Capecitabine Versus S-1 in Elderly Advanced Gastric Cancer (AGC): Randomized Trial
A significant proportion of advanced gastric cancer (AGC) occurs in individuals 65 years of age and older. In addition, patient delay in seeking care for symptoms results in diagnosis at a more advanced stage than that seen in…
- Trial name
- NCT00278863
- Testing
- S-1, Capecitabine
- Where
- 9 sites in South Korea
- Volunteers
- 96 people
- Sponsor
- Asan Medical Center
Lung Cancer
Stepped Palliative Care Versus Early Integrated Palliative Care in Patients With Advanced Lung Cancer
This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer
- Trial name
- STEP PC (NCT03337399)
- Testing
- Stepped PC, Early Integrated PC
- Where
- 3 sites in United States
- Volunteers
- 507 people
- Sponsor
- Massachusetts General Hospital
Gastrointestinal Cancer
Perioperative Palliative Care Surrounding Cancer Surgery for Patients & Their Family Members
The study goal is to compare surgeon-palliative care team co-management, versus surgeon alone management, of patients and family members preparing for major upper gastrointestinal cancer surgery.
- Trial name
- PERIOP-PC (NCT03611309)
- Testing
- Surgeon-palliative care team co management, Surgeon team alone management
- Where
- 5 sites in United States
- Volunteers
- 379 people
- Sponsor
- Stanford University
Prostate Cancer
Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration
The purpose of this study is to compare how subjects feel after receiving injections of two different types of GnRH six months apart.
- Trial name
- NCT01161563
- Testing
- Triptorelin pamoate, Leuprolide acetate
- Where
- 16 sites in United States
- Volunteers
- 118 people
- Sponsor
- Watson Pharmaceuticals
Cancer
Surgery for Cancer With Option of Palliative Care Expert
Frequently people diagnosed with cancer experience physical and emotional symptoms during the course of their disease. These symptoms can be very distressing to both the patient and the family members.
- Trial name
- SCOPE (NCT03436290)
- Testing
- Palliative Care Intervention
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Vanderbilt University Medical Center
Lung Cancer
Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer
This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer and their families.
- Trial name
- REACH PC (NCT03375489)
- Testing
- Telehealth Palliative Care, In-person Palliative Care
- Where
- 23 sites in United States
- Volunteers
- 1,798 people
- Sponsor
- Massachusetts General Hospital
Kidney Failure, Chronic
Advance Care Planning With Older Patients Who Have End-stage Kidney Disease
This study will test the feasibility of carrying out a randomised controlled trial, incorporating a mixed methods process evaluation, to evaluate advance care planning with older patients who have end-stage kidney disease.
- Trial name
- ACREDiT (NCT02631200)
- Testing
- Advance care plan
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Queen's University, Belfast
Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer
EL CENTRO: Engaging Latinos in the Center of Cancer Treatment Options
The objective of this study is to improve the chemotherapy decision making process for Latinos with advanced gastrointestinal cancers.
- Conditions
- Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT03602885
- Testing
- Usual chemotherapy education (CE), Chemotherapy education intervention (CEI)
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Colorectal Cancer, Bladder Cancer
Feasibility Testing of Patient Reported Outcomes - Informed Symptom Management System (PRISMS)
This is a proof-of-concept pilot randomized clinical trial to test the feasibility of the innovative Patient-Reported Outcomes-Informed Symptom Management System (PRISMS) to enhance personalized supportive care for cancer…
- Conditions
- Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- PRISMS (NCT04492007)
- Testing
- Patient-Reported Outcomes-Informed Symptom Management System (PRISMS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center