Clinical trials: Palliative Radiotherapy
Unresectable Multiple Brain Metastases
Supplementation of L-arginine in Patients With Non-resectable Brain Metastases
This study evaluates the nutritional supplement arginine as supportive measure for patients with unresectable metastatic brain tumors that receive radiation therapy with palliative intent
- Trial name
- NCT02844387
- Testing
- L-arginine hydrochloride solution
- Volunteers
- 70 people
- Sponsor
- Instituto de Oncología Ángel H. Roffo
Head and Neck Neoplasms, Recurrence
DAHANCA 20 Palliative Radiotherapy for Head and Neck Cancer
Palliative radiotherapy for head and neck cancer is widely used but the effect and side effects are largely unknown. We will study the effect of short hypofractionated palliative radiotherapy (20 Gy in 4 fractions) on symptom…
- Conditions
- Head and Neck Neoplasms, Recurrence, Neoplasms, Second Primary
- Trial name
- NCT00400426
- Testing
- Radiotherapy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Thoracic Cancer, Radiotherapy
Short Course Radiation Therapy in Palliative Treatment of Thoracic Cancer
Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic thoracic malignant lesions
- Conditions
- Thoracic Cancer, Radiotherapy, Palliative Care
- Trial name
- NCT03804307
- Testing
- standard treatment, short course treatment
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Palliative Care
Short Course Radiation Therapy in Palliative Treatment
The study wants to define the maximum tolerated dose (MTD), safety and efficacy of a short course radiation treatment in patients with symptomatic advanced head and neck cancer.
- Trial name
- NCT03196700
- Testing
- Short course radiotherapy
- Volunteers
- 48 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Metastatic Breast Cancer
Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer
This is a phase 2, open-label, single-arm trial designed to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in combination with pembrolizumab following disease progression after two prior lines of…
- Trial name
- NCT04990921
- Testing
- Palliative Radiation and Pembrolizumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Bone Metastases
Lazanda in Cancer Patients Receiving Palliative Radiation
Advanced cancer patients often require palliative (pain relieving) radiotherapy to treat cancer-related symptoms. The delivery of radiation requires patients to lie still on a hard flat surface, which can result in significant…
- Trial name
- NCT03071744
- Testing
- Lazanda
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Joseph Ma
Carcinoma, Non-Small-Cell Lung, Metastatic Lung Non-Small Cell Carcinoma
Palliative RadIotherapy of Multiple Metastatic Sites Before First Line of Systemic Therapy With Immune Checkpoint Inhibitors and Chemotherapy in Metastatic Non-Small-Cell Lung Cancer
The study is designed as a non-randomized Phase 2 clinical intervention study. The study will include patients with disseminated Non-Small Cell Lung Carcinoma (NSCLC) which are eligible for first line of systemic treatment with…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Metastatic Lung Non-Small Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- PRIMM (NCT05440916)
- Testing
- Palliative Radiotherapy: 5 x 4Gy, chemotherapy + immune checkpoint inhibitors
- Where
- 3 sites in Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Maribor
Head and Neck Cancer
The GOAL27-6 Study
The main purpose and goal of this study is to find out if a particular course of radiotherapy for non-curable cancers, together with palliative care support, can help improve patients' quality of life.
- Trial name
- NCT05859828
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- East and North Hertfordshire NHS Trust
Epiduritis, Vertebral Bone Metastasis
Stereotactic Radiotherapy for SPinal Metastases With Limited Extent of Epidural Disease
This study evaluates a new radiation treatment approach for patients with cancer that has spread to the spine (vertebral metastases) and involves limited extension around the spinal cord without causing compression…
- Trial name
- SPEED-RT (NCT07656883)
- Testing
- Stereotactic Body Radiotherapy (SBRT), Conventional External Beam Radiotherapy
- Where
- 14 sites in France
- Volunteers
- 167 people
- Sponsor
- Institut Cancerologie de l'Ouest
Palliative Radiotherapy, Radiotherapy, Intensity-Modulated
Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single
One third of patients treated in the radiation oncology departments are treated with palliative intent. These patients can be unwell due to their advanced disease and suffering from pain and other symptoms related to metastases.
- Trial name
- ASPIRE single (NCT04658537)
- Testing
- Radiation Therapy
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal North Shore Hospital
Advanced Nsclc
Plasma miRNAs Predict Radiosensitivity of Different Fractionation Regimes in Palliative Radiotherapy for Advanced Non-small Cell Lung Cancer：Multicenter Controlled Study.(RadmiR-01)
Lung cancer is a malignant tumor that causes the highest morbidity and mortality, and the main pathological type is non-small cell lung cancer (NSCLC). Most of them present with advanced stage at diagnosis.
- Trial name
- NCT03074175
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Xinqiao Hospital of Chongqing
Merkel Cell Carcinoma
Palliative RT & Anti-PD-1/PD-L1 Checkpoint Blockade in Metastatic Merkel Cell Carcinoma
The primary objectives of this study are to assess 1) the safety and 2) efficacy of combining Anti-PD-1/PD-L1 blockade with palliative radiation therapy in patients with Stage IV Merkel Cell Carcinoma.
- Trial name
- NCT03988647
- Testing
- Pembrolizumab, Radiation Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Non-Small Cell Lung Cancer
A Randomized Phase III Study of Palliative Radiation of Advanced Central Tumors With Intentional Avoidance of the Esophagus
A randomized phase II study of palliative radiation of advanced central lung tumors with intentional avoidance of the esophagus.
- Trial name
- PROACTIVE (NCT02752126)
- Testing
- Conventional radiotherapy, Esophageal-Sparing Intensity-Modulated Radiotherapy
- Where
- 7 sites in Canada
- Volunteers
- 90 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Rectal Cancer
Hypofractionated Palliative Radiotherapy in Patients With Advanced Non-operable Rectal Cancer
Many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases.
- Trial name
- NCT03853733
- Testing
- rectal cancer radiotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Palliative Care
Short Course Radiotherapy in Complicated Bone Metastases Palliation
The study wants to define the maximum tolerated dose (MTD), safety and efficacy of a short course radiation treatment in patients with complicated bone metastases.
- Trial name
- NCT03455231
- Testing
- Short course radiotherapy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Non-small Cell Lung Cancer
Study of Durvalumab Following Radiation Therapy in Patients With Stage 3 Unresectable NSCLC Ineligible for Chemotherapy
This is a Phase II open-label, single-arm, multicenter, international study to evaluate the clinical activity of durvalumab in patients with Stage III unresectable NSCLC who are deemed to be ineligible for chemotherapy per…
- Trial name
- DUART (NCT04249362)
- Testing
- Durvalumab
- Where
- 35 sites in United States, France and 4 more
- Volunteers
- 102 people
- Sponsor
- AstraZeneca
Head and Neck Carcinoma, Localized Head and Neck Carcinoma
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)
This trial tests how well personalized ultra fractionated stereotactic adaptive radiotherapy (PULSAR) works together with HyperArc© radiation treatment planning technology for palliative (holistic pain and symptom control) tumor…
- Conditions
- Head and Neck Carcinoma, Localized Head and Neck Carcinoma, Metastatic Head and Neck Carcinoma, Recurrent Head and Neck Carcinoma
- Trial name
- PULS-Pal (NCT06572423)
- Testing
- Personalized ultrafractionated stereotactic adaptive radiotherapy, Volume Modulated Arc Therapy, Computed Tomography
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Metastatic Cancer or Locally Advanced, Patients Receiving Palliative Radiation
Use of a Video Decision Tool to Improve Informed Decision-Making in Hospitalized Patients Considering Palliative Radiation Therapy
The purpose of this study is to assess the effectiveness and acceptability of a recently created informative video geared for patients who have been evaluated by a radiation oncologist for palliative radiation therapy during a…
- Trial name
- NCT01667965
- Testing
- questionnaires
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bone Metastasis, Oncology Pain
Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality
The goal of this clinical trial is to assess the impact of reducing the volume of palliative metastatic bone irradiation on analgesic effectiveness at day 30 and to evaluate the efficiency of telemonitoring in identifying…
- Trial name
- SPINAL (NCT06884332)
- Testing
- Sparing irradiation, Conventional spinal irradiation
- Where
- 4 sites in France
- Volunteers
- 598 people
- Sponsor
- Institut de Cancérologie de Lorraine
Malignant Solid Neoplasm
Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction
This phase I/II trial studies the side effects of interstitial photodynamic therapy following palliative radiotherapy and how well it works in treating patients with inoperable malignant central airway obstruction.
- Trial name
- NCT06306638
- Testing
- Biospecimen Collection, Computed Tomography, Endobronchial Ultrasound Bronchoscopy
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Roswell Park Cancer Institute