Clinical trials: Paludism
Malaria,Falciparum, Malaria
Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria
This is an open-label, adaptive study that will utilise the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile of pyronaridine.
- Conditions
- Malaria,Falciparum, Malaria, Malaria Recrudescence, Parasitemia
- Trial name
- NCT05287893
- Testing
- Pyronaridine, P. falciparum IBSM infection
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Severe Malaria
Severe and Cerebral Malaria Investigated Through Host Metabolomics
The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. Despite treatment between 10-30% of patients with severe malaria die.
- Trial name
- NCT02451904
- Testing
- Observation
- Where
- Bangladesh
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria Diagnosis, Malaria,Falciparum
Evaluation of the Performance of a hsRDT Versus cRDT in Reactive Case Detection of Malaria Infections
A systematic review assessing the role, appropriateness and benefits of the active case detection strategy, both proactive and reactive, in low malaria transmission settings.
- Trial name
- NCT03511443
- Testing
- hsRDT
- Where
- Burma
- Volunteers
- 1,980 people, healthy volunteers welcome
- Sponsor
- University Research Co, LLC
Plasmodium Falciparum Infection
PfSPZ Challenge in Non-immune Adults in Baltimore, USA
This is a single center, randomized and controlled human study to optimize controlled human malaria infection (CHMI) administered by direct venous inoculation (DVI).
- Trial name
- NCT02780154
- Testing
- PfSPZ (7G8) Challenge, PfSPZ (NF54) Challenge
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plasmodium Knowlesi Infection
Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi
This study aims to determine the sensitivity, specificity, and practical value of two new molecular diagnostic assays compared to a more classical nested molecular diagnostic assay and the routine microscopy (both of which are…
- Trial name
- NCT03988296
- Where
- 3 sites in Malaysia
- Volunteers
- 116 people
- Sponsor
- Duke University
Malaria
Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy 2 (TRANSACT2)
Artemisinin combination therapy (ACT) with artemether lumefantrine (AL) is currently the first line treatment policy in Kenya. AL is an efficacious drug that also has the capacity to reduce malaria transmission to mosquitoes.
- Trial name
- TRANSACT2 (NCT01939886)
- Testing
- Mefloquine - Artesunate, Artemether-lumefantrine combination
- Where
- Kenya
- Volunteers
- 219 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria in Pregnancy, Pregnancy
Azithromycin (AZ) and Sulphadoxine-pyrimethamine (SP) for Malaria Prevention in Pregnant Women (IPT-AZ/IPT-SP)
AZITHROMYCIN VERSUS SULPHADOXINE-PYRIMETHAMINE FOR PROPHYLAXIS AGAINST MALARIA IN PREGNANCY IN OWO, SOUIHWESTERN NIGERIA: A RANDOMISED CONTROLLED TRIAL OBJECTIVE: This study is to compare the efficacy of Azithromycin versus…
- Trial name
- NCT03944317
- Testing
- Sulfadoxine pyrimethamine, Azithromycin
- Where
- Nigeria
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Federal Medical Centre, Owo
Malaria,Falciparum, Plasmodium Falciparum
Safety and Protective Efficacy of Pb(PfCS@UIS4)
In the underlying study, a genetically modified P. berghei parasite is used. P. berghei is one of the four Plasmodium species that causes malaria in rodents. The hypothesis is that immunization of humans with P.
- Conditions
- Malaria,Falciparum, Plasmodium Falciparum, Plasmodium Berghei, Controlled Human Malaria Infection (CHMI)
- Trial name
- PbVac (NCT03138096)
- Testing
- Pb(PfCS@UIS4)-infected mosquitoes, Challenge infection P. falciparum
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Severe Malaria
Very Severe Malaria Treated by Intravenous Artesunate
In endemic areas, Plasmodium falciparum malaria exacts a huge public health toll, causing close to half a million deaths each year. In non-endemic industrialized areas, imported malaria may develop.
- Trial name
- Palustar (NCT04516317)
- Testing
- None (Observational study Group intravenous artesunate), None (Observational study Group intravenous quinine)
- Where
- France
- Volunteers
- 578 people
- Sponsor
- Dr Fabrice BRUNEEL
Vaccination
Testing a Biometric Identification System to Improve Malaria Vaccine Completion
Receiving all four doses of the malaria vaccine can significantly protect children against malaria illness, hospitalization, and death. However, in Ghana, only 46% of children complete the full vaccination sequence.
- Trial name
- NCT07261280
- Testing
- HEALTH FACILITY INTERVENTION, INDIVIDUAL INTERVENTION
- Where
- Ghana
- Volunteers
- 4,715 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Malaria
Experimental Human Malaria Infection by PfSPZ
The study is a single center, varied dose, open label study. A maximum of eighteen volunteers will be exposed to live NF54 P. falciparum sporozoites (PfSPZ Challenge) by intradermal injection.
- Trial name
- NCT01086917
- Testing
- PfSPZ Challenge
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria
A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Vaccine
The purpose of this pre-licensure cohort study was to estimate the incidence of adverse events of special interest (AESI), other adverse events (AE) leading to hospitalisation or death, meningitis and malaria in sub-Saharan…
- Trial name
- NCT02374450
- Testing
- Blood collection
- Where
- 5 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 36,366 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites
This study is to assess the safety, tolerability, and biomarkers of protection in healthy malaria-naïve adults, who will receive bites from Anopheles stephensi mosquitoes either infected with Plasmodium falciparum Sporozoites…
- Trial name
- IMRAS (NCT01994525)
- Testing
- PfRAS, Challenge
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
P. Falciparum Malaria, P. Falciparum Malaria Mixed Infection
Evaluating the Efficacy of Artesunate-mefloquine and the Relative Roles of Resistance Genetic Markers
This is a retrospective non randomized cohort to evaluate efficacy of MAS3 on patients with uncomplicated P. falciparum malaria or mixed infection (P. falciparum + a non-falciparum species).
- Trial name
- MMA (NCT02427360)
- Where
- Thailand
- Volunteers
- 1,022 people
- Sponsor
- University of Oxford
Malaria
Pharmacokinetic Study of Multi-dose Chloroquine
Chloroquine (CQ) remains an alternative cheap, safe and widely available drug. Our previous research has shown that double (50 mg/kg) standard dose CQ given in split doses had a 95% efficacy and was well tolerated and safe.
- Trial name
- NCT01814423
- Testing
- Chloroquine-base 50 mg, Chloroquine-base 70 mg
- Where
- Guinea-Bissau
- Volunteers
- 30 people
- Sponsor
- Bandim Health Project
Plasmodium Falciparum Infection
PfSPZ Challenge in Healthy Malaria-Naïve Adults in the United States
This phase I trial of the replication-intact PfSPZ Challenge vaccine given under CQ cover will enroll 28 healthy volunteers to receive PfSPZ or placebo, as well as suppressive doses of chloroquine (CQ)on varying schedules.
- Trial name
- NCT02773979
- Testing
- Chloroquine, PfSPZ (NF54) Challenge
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria,Falciparum, Malaria
Efficacy, Effect on Gametocytes and Tolerability of the Addition of Artesunate to Amodiaquine in Colombia
The primary goal of this study is to quantify the benefit of adding artesunate to amodiaquine in treating patients with uncomplicated P. falciparum malaria, in a low transmission area in Colombia.
- Conditions
- Malaria,Falciparum, Malaria, Antimalarials
- Trial name
- NCT00378625
- Testing
- Artesunate
- Where
- Colombia
- Volunteers
- 360 people
- Sponsor
- Centro Internacional de Entrenamiento e Investigaciones Médicas
Malaria
Molecular Basis of Erythrocyte Invasion by Plasmodium Vivax Into Duffy-Negative Erythrocytes in Mali
Background: Malaria is caused by parasites carried by some mosquitos. When the mosquitos bite people, the parasites can infect them. One of these parasites is Plasmodium vivax (P. vivax). Some children have P.
- Trial name
- NCT03304691
- Where
- 2 sites in Mali
- Volunteers
- 667 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Vivax
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
The aim of this study is to collect efficacy and safety data to support the registration of tafenoquine in India.
- Trial name
- NCT06666491
- Testing
- Tafenoquine, Primaquine, Chloroquine
- Where
- 5 sites in India
- Volunteers
- 324 people
- Sponsor
- GlaxoSmithKline
Fever
Treatment of Fever Due to Malaria With Ibuprofen
Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever.
- Trial name
- NCT00167713
- Testing
- Ibuprofen
- Where
- Gabon
- Volunteers
- 50 people
- Sponsor
- Albert Schweitzer Hospital