Clinical trials: Pancreas Disease
Mucoviscidosis Involving the Lung
Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test
The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat.
- Trial name
- BUBBLE TEST (NCT03584841)
- Testing
- Iontophoresis sessions in forearm of subjects with pilocarpine
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Pancreatic Neoplasms
FOLFIRINOX Plus PF-04136309 in Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma
This phase I trial studies the side effects and optimal dose of PF-04136309 when given with combination chemotherapy (FOLFIRINOX; 5-fluorouracil, leucovorin, irinotecan, oxaliplatin) in treating patients with locally advanced or…
- Trial name
- NCT01413022
- Testing
- Oxaliplatin, Irinotecan, Leucovorin
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Washington University School of Medicine
Cystic Fibrosis, Pancreatic Cystic Fibrosis
Behavioral & Nutritional Treatment to Help CF Preschoolers Grow
The primary objective of this NIH funded clinical trial is to conduct a multi-center, randomized, controlled trial comparing two interventions: a behavioral plus nutrition intervention to a nutrition intervention.
- Trial name
- NCT00241969
- Testing
- Behavioral and Nutrition Treatment, Education and Attention Control
- Where
- 5 sites in United States
- Volunteers
- 78 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pancreas Cancer
Bethanechol Prior to Pancreatic Surgery
The primary objective of this study is to assess the impact of bethanechol therapy on tumor activity by looking at biomarkers of proliferation, inflammation, and stem cell markers in post-treatment specimens compared to…
- Trial name
- NCT03572283
- Testing
- Bethanechol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Columbia University
Insulinoma
EUS-guided Ethanol Ablation of an Insulinoma
The present study aims to evaluate the feasibility, safety and efficacy of EUS-guided ethanol ablation of an insulinoma.
- Trial name
- EUS (NCT02121366)
- Testing
- EUS-guided ethanol ablation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangxi Medical University
Insulin Secretion, Insulin Resistance
Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics
1. The purpose of this study is to determine whether Sitagliptin therapy suppress glucagon release and improve glucose control in Chinese type 2 diabetic. 2.
- Trial name
- NCT01610154
- Testing
- Sitagliptin
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Guangwei Li
Shwachman-Diamond Syndrome, SDS
Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform
The Shwachman-Diamond Syndrome Global Patient Survey and Collaboration Program (SDS-GPS) is an opportunity for patients and their families - from anywhere in the world - to share their experience living with SDS via a safe…
- Conditions
- Shwachman-Diamond Syndrome, SDS, IBMF, Congenital Neutropenia
- Trial name
- SDS-GPS (NCT06999954)
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Shwachman-Diamond Syndrome Alliance Inc
Cystic Fibrosis
Analysis of Remote Monitoring/Virtual Clinic Data in Adult Patients With Cystic Fibrosis (Project Breathe)
The goal of this observational study is to learn about the impact of home monitoring in adults with cystic fibrosis. The main questions it aims to answer are: how people with CF find using home monitoring equipment to see if by…
- Trial name
- NCT06222905
- Testing
- non interventional
- Where
- 2 sites in United Kingdom
- Volunteers
- 475 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Thrombosis, Deep Venous Thrombosis
Venous Thromboembolism and Haemostatic Disturbances in Patients With Upper Gastrointestinal Cancer
Cancer is a well known risk factor for venous thromboembolism (VTE) such as deep venous thrombosis (DVT) and pulmonary embolism (PE).
- Conditions
- Thrombosis, Deep Venous Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- GIVTE (NCT00660205)
- Where
- Denmark
- Volunteers
- 285 people
- Sponsor
- University of Aarhus
Fatty Pancreas, Overweight
Efficacy of Mazdutide on Fatty Pancreas
This is a randomized, double-blind, placebo-controlled, parallel-group, single-center clinical trial designed to evaluate the efficacy and safety of mazdutide in improving fatty pancreas in patients with overweight or obesity.
- Conditions
- Fatty Pancreas, Overweight, Obesity
- Trial name
- NCT07803705
- Testing
- mazdutide
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Tongji Hospital
Colorectal Cancer, Islet Cell Tumor
Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
- Conditions
- Colorectal Cancer, Islet Cell Tumor, Liver Cancer, Metastatic Cancer
- Trial name
- NCT00019786
- Testing
- isolated perfusion, melphalan, conventional surgery
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pancreatic Cancer
Comparing Newly Developed PreCore Needle With Conventional Fine Needle in Suspected Unresectable Pancreatic Cancer
Background: Pancreatic cancer is associated with a poor prognosis. Therefore, rapid and accurate diagnosis of a pancreatic mass is important to direct patient management.
- Trial name
- NCT01876069
- Testing
- 22 gauge ProCore needle aspiration, 22 gauge Fine needle aspiration
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Pancreatitis
Ulinastatin in Severe Acute Pancreatitis
This study aims to evaluate the effect of ulinastatin in the treatment and prevention of organ failure in severe acute pancreatitis.
- Trial name
- NCT01132521
- Testing
- ulinastatin
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Techpool Bio-Pharma Co., Ltd.
Pancreatic Cancer, Pancreatic Surgery
Surgery for Pancreatic Cancer With Oligo-Metastasis
Pancreatic cancer is increasing in incidence and will be the second leading cause of cancer-related deaths in 2030 in the West. Only 10 to 15% of patients are eligible for curative resection with long-term survival rarely…
- Trial name
- SPaM (NCT04196816)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis (CF)
Exercises' Effect on Muscle Strength, Aerobic Capacity and Respiratory Functions in Cystic Fibrosis
This research aims to evaluate the effects of upper and lower limb exercises on muscle strength and pulmonary function in children diagnosed with CF.
- Trial name
- NCT07508904
- Testing
- Arm Cycle Ergometry, Leg Cycle Ergometry
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Pancreas Cancer, Gastrointestinal Adenocarcinoma
An Ultrasound Imaging Technique to Measure Tumors in People With Pancreatic Ductal Adenocarcinoma (PDAC) or Gastrointestinal (GI) Adenocarcinoma
The purpose of this study is to see if ultrasound images that are analyzed by a special computer program can be used to measure the size of PDAC tumors in the liver as accurately as CT scans that involve contrast material (also…
- Trial name
- NCT04837833
- Testing
- ultrasound
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cystic Fibrosis, Pneumonia
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo
Cystic fibrosis patients suffer from a chronic destruction of the lung, frequent and finally chronic pneumonia and a reduced life expectancy.
- Trial name
- APA-IIb (NCT01309178)
- Testing
- Amitriptyline, Mannite
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital Tuebingen
Pancreas Cancer
Establishment of Radiomics Database by Clinical Application of Multiparametric MRI Based on Incoherent Undersampling
This study aims to establish radiomics database for pancreas cancer from multiparametric MRI including DCE-MRI obtained by using incoherent undersampling and radial acquisition for clinical staging as well as quantitative…
- Trial name
- NCT02944006
- Testing
- multi-parametric MRI
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Seoul National University Hospital
Pancreatic Adenocarcinoma
Gene Therapy of Pancreatic Ductal Adenocarcinoma
Near 85% of patients with pancreatic adenocarcinoma are diagnosed with a locally advanced and/or metastatic unresectable tumor. In these patients chemotherapy (such as gemcitabine) is given as a palliative therapy.
- Trial name
- TherGAP (NCT01274455)
- Testing
- Gene Therapy product CYL-02 = plasmid DNA pre-complexed to linear polyethylenimine encoding sst2 + dck::umk genes
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Non-small Cell Lung Cancer, Colorectal Carcinoma
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Phase I Study, a master protocol to investigate TCR-Engineered T cells recognizing KRAS mutations in adult subjects with Unresectable, Advanced, and/or Metastatic Solid Tumors.
- Conditions
- Non-small Cell Lung Cancer, Colorectal Carcinoma, Pancreatic Ductal Adenocarcinoma, Endometrial Cancer
- Trial name
- NCT06218914
- Testing
- NT-112: Autologous, engineered T Cells targeting KRAS G12D, AZD0240: Autologous, engineered T Cells targeting KRAS G12D
- Where
- 18 sites in United States
- Volunteers
- 108 people
- Sponsor
- AstraZeneca
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