Clinical trials: Pancreas Diseases
Cystic Fibrosis
Sleep in Patients With Cystic Fibrosis
The aim of the study is to identify the parameters that are associated with nocturnal hypoventilation in children and adults with cystic fibrosis.
- Trial name
- Sommeil (NCT00804661)
- Testing
- SENTEC device
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Glucolipotoxicity and Type 2 Diabetes
Elevations of blood glucose and lipid are thought to be deleterious to the insulin secretory function of the pancreas. This is known as glucolipotoxicity. However, few studies have examined this in detail.
- Trial name
- NCT01375270
- Testing
- Glucotoxicity, Lipotoxicity
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pancreatic Cancer
Multi-Modality Therapy for Untreated Patients With Resectable or Marginally Resectable Pancreatic Cancer
To assess the ability of a combination of updated and approved modalities in the treatment of first line pancreatic cancer patients to increase the time to Progression Free Survival
- Trial name
- NCT01760694
- Testing
- Multi-Modality; IORT, Surgery, Radiation, Chemotherapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Southwestern Regional Medical Center
Cystic Fibrosis, Children
An Intervention-Based Approach to Strengthen the Psychological Health of Children With Cystic Fibrosis and Their Mothers
Cystic fibrosis (CF) is a life-threatening exocrine gland disease that is often diagnosed in childhood, and its incidence tends to increase and affect physical and mental health.The purpose of this study is to evaluate the…
- Conditions
- Cystic Fibrosis, Children, Resilience,Psychological, Laughter Yoga
- Trial name
- NCT06280066
- Testing
- Intervention Program Based on Strengthening the Psychological Resilience of Children Diagnosed with Cystic Fibrosis and Their Mothers
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Cystic Fibrosis
A Study to Evaluate the Relative Bioavailability of a Fixed-dose Combination Tablet of VX-121/Tezacaftor/Deutivacaftor
The purpose of this study is to evaluate the relative bioavailability of a fixed-dose combination tablet (FDC) of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA).
- Trial name
- NCT05535959
- Testing
- VX-121/TEZ/D-IVA
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis
A Phase 2 IV Gallium Study for Patients With Cystic Fibrosis (IGNITE Study)
The purpose of this study is to assess the efficacy of IV gallium to improve pulmonary function as measured by a 5% or greater relative improvement in forced expiratory volume in one second (FEV1) from baseline to Day 28.
- Trial name
- NCT02354859
- Testing
- Gallium nitrate, Normal Saline
- Where
- 23 sites in United States
- Volunteers
- 119 people
- Sponsor
- University of Washington
Cystic Fibrosis
Evaluation of Sit-to-stand Test in Patients With Cystic Fibrosis and Matched Controls.
Introduction: In recent years, since the discovery of the cystic fibrosis (CF) transmembrane conductance regulator gene in human skeletal muscle, there appears to be growing interest in the measurement of muscle function in CF.
- Trial name
- STS-CF (NCT03524859)
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Metastatic Pancreatic Cancer
Trial of Erlotinib, Gemcitabine and Cisplatin in Metastatic Pancreatic Cancer
The purpose of this study is to determine the response rate of gemcitabine, cisplatin and erlotinib in metastatic pancreatic cancer.
- Trial name
- NCT00922896
- Testing
- Gemcitabine, Cisplatin, Erlotinib (Tarceva)
- Where
- 3 sites in South Korea
- Volunteers
- 22 people
- Sponsor
- Gyeongsang National University Hospital
Pancreatitis
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis
This pilot study is a feasibility, safety, and preliminary benefits study to look at whether giving the calcium channel blocker amlodipine to people with hereditary pancreatitis as a prophylactic measure can reduce the…
- Trial name
- NCT00156403
- Testing
- amlodipine (drug)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes Mellitus
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
The purpose of this pilot study is to test the safety and feasibility of using two or three research modules in conjunction with an automated insulin delivery device (AID).
- Trial name
- NCT04784637
- Testing
- Web Simulation Tool (WST), Behavioral Adaptation Module (BAM), Auto Titration Module (ATM)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Metastatic Pancreatic Ductal Adenocarcinoma
A Study of the Safety and Tolerance of CAN04 in Combination With FOLFIRINOX in Subjects With Metastatic Pancreatic Ductal Adenocarcinoma
This study will consider the safety and effectiveness of a study drug, CAN04, in combination with FOLFIRINOX, in the treatment of metastatic pancreatic ductal adenocarcinoma.
- Trial name
- CAPAFOUR (NCT04990037)
- Testing
- CAN04, FOLFIRINOX
- Where
- 9 sites in France, Spain
- Volunteers
- 25 people
- Sponsor
- Cantargia AB
Solid Tumor, Adult, Lung Adenocarcinoma
TP53 R248Q TCR-T Cell Therapy for Advanced Solid Tumor
To evaluate the safety and efficacy of T cell therapy with mutated TP53 R248Q specific TCR transduction in patients with advanced solid tumor expressing the TP53 R248Q mutation and the HLA-A*11:01 allele.
- Conditions
- Solid Tumor, Adult, Lung Adenocarcinoma, Pancreas Cancer, Colorectal Cancer
- Trial name
- NCT06619886
- Testing
- Autologous, engineered T Cells targeting TP53 R248Q
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pancreatic Cancer
Trabectedin in Treating Patients With Metastatic Pancreatic Cancer After First-Line Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as trabectedin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PACT-18 (NCT01339754)
- Testing
- trabectedin
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer, Surgery
Quality of Life in Elderly Patients After Pancreatic Cancer Surgery
Pancreatic cancer mainly affects the elderly, with over 85% of patients diagnosed after the age of 60 and over half after the age of 70.
- Conditions
- Pancreatic Cancer, Surgery, Elderly
- Trial name
- ADL_DPC_PA (NCT06079229)
- Testing
- Phone call
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Malignant Breast Neoplasm, Malignant Colorectal Neoplasm
18F-Fluoroazomycin Arabinoside PET-CT in Diagnosing Solid Tumors in Patients
This early phase I trial studies how well 18F-fluoroazomycin arabinoside positron emission tomography (PET)-computed tomography (CT) works in diagnosing solid tumors.
- Conditions
- Malignant Breast Neoplasm, Malignant Colorectal Neoplasm, Malignant Pancreatic Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT03168737
- Testing
- Computed Tomography, Fluorine F 18-fluoroazomycin Arabinoside, Positron Emission Tomography
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center
Severe Acute Pancreatitis
Effect of Epidural Anesthesia on Pancreatic Perfusion and Clinical Outcome in Patients With Severe Acute Pancreatitis
The aim of the study is to evaluate the safety, the potential beneficial effect of epidural anesthesia on pancreatic perfusion and clinical outcome of patients with severe acute pancreatitis.
- Trial name
- NCT01607996
- Testing
- Epidural anesthesia, Patient controlled intravenous analgesia
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University Hospital, Geneva
Pancreatic Cancer
Safety and Feasibility of imILT Locally Advanced Pancreatic Cancer (LAPC)
10 Patients with Locally Advanced Pancreatic Cancer, no further responsive to neoadjuvant treatments but with a Stage-III disease will be submitted to imILT (Immunostimulating Interstitial Laser Thermotherapy).
- Trial name
- NCT02702986
- Testing
- immunostimulating Interstitial Laser Thermotherapy, Laser
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Universita di Verona
Borderline Resectable Pancreatic Cancer, High-Risk Resectable Pancreatic Cancer
Surufatinib in Combination With Iparomlimab and Tuvonralimab Injection and AG Chemotherapy for Neoadjuvant Therapy of HRPC or BRPC
This is a prospective, single-center, single-arm phase 2 study evaluating the efficacy and safety of neoadjuvant surufatinib plus iparomlimab and tuvonralimab injection and nab-paclitaxel/gemcitabine chemotherapy in patients with…
- Trial name
- ZSPAC-22 (NCT07833241)
- Testing
- Surufatinib Plus Iparomlimab and Tuvonralimab and AG Chemotherapy, Gemcitabine plus Capecitabine, Modified FOLFIRINOX
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer, Prostate Cancer
Holistic Acupuncture for Patients With Chemotherapy Induced Nausea
The study explores whether acupuncture as a supplement to conventional antiemetic medicine is superior in reducing the level of chemotherapy induced nausea compared to conventional anitemetic medicine alone.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Gynaecologic Cancer
- Trial name
- NCT07201194
- Testing
- Holistic acupuncture and acupressure, Standard medical treatment
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
Pancreatitis
Acute Pancreatitis Patient Registry To Examine Novel Therapies In Clinical Experiences 2
This study is an ancillary of APPRENTICE. This will be the international based study.
- Trial name
- APPRENTICE2 (NCT03075631)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 1,183 people
- Sponsor
- University of Pittsburgh
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