Clinical trials: Pancreas Diseases
Bladder Cancer, Glioma
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer
The objective of this study is to assess two novel positron emission tomography (PET) radiotracers, [64Cu]CM500 and [68Ga]CM500, for Positron Emission Tomography-Magnetic Resonance Imaging (PET-MR) and Positron Emission…
- Conditions
- Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer
- Trial name
- NCT07781852
- Testing
- [64Cu]CM500, [68Ga]CM500, PET/MR
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lumina Pharmaceuticals Inc
Ovarian Cancer, Breast Cancer
'OLAP' (OLAparib Regulatory Post-marketing Surveillance)
The objectives of this study are to assess safety and effectiveness of Lynparza tablet (olaparib, hereinafter "the study drug") in a real world setting in patients who are prescribed with the study drug according to the approved…
- Conditions
- Ovarian Cancer, Breast Cancer, Prostate Cancer, Pancreatic Cancer
- Trial name
- OLAP (NCT04553926)
- Where
- 18 sites in South Korea
- Volunteers
- 661 people
- Sponsor
- AstraZeneca
Pancreatic Cancer, Surgery--Complications
ERAS Protocol in Pancreaticoduodenectomy and Total Pancreatectomy
In the study, the enhanced recovery after surgery (ERAS) program is applied to total pancreatectomy (TP) and low-risk pancreaticoduodenectomy (PD) patients identified by a small number of acinar cells in the cut edge of the…
- Conditions
- Pancreatic Cancer, Surgery--Complications, Pancreatic Fistula, Delayed Gastric Emptying
- Trial name
- NCT03757455
- Testing
- ERAS protocol preoperative actions, ERAS protocol intraoperative actions, ERAS protocol postoperative actions
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Tampere University Hospital
Hearing Loss, Sensorineural, Cystic Fibrosis
A Study of Web and Tablet-based Interactive Audiometry in Adults With CF
Adults with CF regularly receive anti-infective therapy that can result in impaired hearing. Recent studies have identified that up to 50% of adults with CF have hearing loss with resulting significant impact on quality of life.
- Trial name
- NCT04400955
- Testing
- Audiometry tablet diagnostic tool and web-based test
- Where
- United Kingdom
- Volunteers
- 156 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pancreatic Cancer
Evaluation of Prognosis With Integrated MRI/PET in Patients With Pancreatic Cancer
The aim of this study was to evaluate MR/PET with both functional and molecular imaging on the prediction of prognosis in patients with suspected pancreatic cancer.
- Trial name
- NCT02550847
- Testing
- The imaging biomarkers determined by MR-PET
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pancreatic Cancer, Periampullary Carcinoma
Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy
The purpose of this study is to evaluate the validity and safety of a modified operative procedure of digestive tract reconstruction following pancreatoduodenectomy which enables the pancreatic juice and bile to bypass at the…
- Trial name
- NCT01931449
- Testing
- Modified method of digestive tract reconstruction, Routine digestive tract reconstruction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southwest Hospital, China
Pancreatic Cancer
Irinotecan Liposome，Albumin Paclitaxel and Gemcitabine First-line Treatment for Pancreatic Cancer
This is a Phase I/II , Open-label , Investigator-initiated Trail of liposomal irinotecan,nab-paclitaxel and gemcitabine as First-line Treatment in Advanced pancreatic cancer.
- Trial name
- NCT06513455
- Testing
- Irinotecan liposome（40mg/m2）, Nab-paclitaxel, Gemcitabine
- Volunteers
- 132 people
- Sponsor
- Harbin Medical University
Acute Lung Injury, Chronic Obstructive Pulmonary Disease (COPD)
Imaging of Peri-operative (periOP) Lung Injury
The aim of study is to determine if 99mTc Annexin V-128 (AxV- 128/Tc) single photon emission computed tomography (SPECT)-computed tomography (CT) can detect perioperative lung injury.
- Trial name
- NCT02978885
- Testing
- SPECT-CT imaging, AxV-128/Tc, Whipple procedure
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Cystic Fibrosis
Study to Validate the Instructions for Use of TOBI® Podhaler™ in Cystic Fibrosis Patients
The purpose of this actual use human factors (HF) study is to validate the approved US TOBI Podhaler Instructions for Use (IFU), by establishing that the IFU effectively communicates the information necessary to achieve safe and…
- Trial name
- NCT02178540
- Testing
- Tobi Podhaler
- Where
- 13 sites in United States
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC)
PRedictiOn Algorithms for the DeTECTion of Early Stage Pancreatic Cancer
Conduct a prospective study to assess the accuracy of a pancreatic cancer risk prediction model.
- Trial name
- PRO-TECT (NCT04883450)
- Testing
- Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente
Metastatic Malignant Neoplasm in the Brain, Metastatic Solid Neoplasm
APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of APN401 in treating patients with pancreatic cancer, colorectal cancer, or other solid tumors that have spread to other places in the body or have come back.
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Metastatic Solid Neoplasm, Recurrent Colorectal Carcinoma, Recurrent Pancreatic Carcinoma
- Trial name
- NCT03087591
- Testing
- Laboratory Biomarker Analysis, siRNA-transfected Peripheral Blood Mononuclear Cells (PBMC) APN401
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Cystic Fibrosis
Vitamin K Supplementation to Reduce Deficiencies in Adults With Cystic Fibrosis
Cystic fibrosis (CF) patients are at risk for vitamin K deficiencies. Supplementation for fat-soluble vitamins A, D, and E is well established, but in CF, there is little data for vitamin K concerning the optimal dose and…
- Trial name
- VITK-FK (NCT04496921)
- Testing
- Vitamin K supplementation, dose #1, Vitamin K supplementation, dose #2
- Where
- 2 sites in Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus Type 1
A Study of the Safety and Efficacy of Pancreatic Endocrine Cell Clusters Implanted Into the Omentum of Type 1 Diabetes Patients With Severe Hypoglycemia
This study will evaluate the safety, efficacy and durability of SR-02 administered to the omentum of patients of Type 1 diabetes with severe recurrent hypoglycemia. The study will also help establish the optimal treatment dose.
- Trial name
- SUGR (NCT06651515)
- Testing
- Allogeneic Pancreatic Endocrine Cell Clusters
- Where
- 2 sites in United States
- Sponsor
- Seraxis
Cystic Fibrosis
Do Physiotherapy Techniques Improve Posture During Admission for a Chest Infection in Adults With Cystic Fibrosis?
Hypothesis: The addition of a series of musculoskeletal techniques to normal optimal care for the treatment of a respiratory exacerbation in inpatient adults with cystic fibrosis, will lead to further improvements in pain…
- Trial name
- NCT00806884
- Testing
- Physiotherapy Musculoskeletal Treatment, Control group measurements
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Solid Tumor
Dose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLC
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of RMC-4630 and cobimetinib in adult participants with relapsed/refractory solid tumors with specific…
- Trial name
- NCT03989115
- Testing
- RMC-4630, Cobimetinib, Drug: Osimertinib
- Where
- 24 sites in United States, South Korea
- Volunteers
- 113 people
- Sponsor
- Revolution Medicines, Inc.
Pancreatitis, Walled Off Pancreatic Necrosis
Bedside Monitoring of Microenvironmental Changes in Infected Pancreatic Collections
This pilot clinical study aims to assess the feasibility and clinical relevance of bedside monitoring of microenvironmental conditions within infected walled-off pancreatic necrosis (WOPN).
- Trial name
- WOPN-MONITOR (NCT07131917)
- Testing
- Miniaturized Intracavitary Monitoring Probe
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Martin Harazim
Acute Pancreatitis
Thoracic Ultrasound on Acute Pancreatitis
Authors design a prospective, longitudinal, descriptive study to identify the findings of thoracic point-of-care ultrasound in patients with acute pancreatitis.
- Trial name
- ECOPANC (NCT04033549)
- Where
- Mexico
- Volunteers
- 49 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Healthy Volunteers
A Study to Assess the Pharmacokinetics and Safety of Co-administered Oral Galicaftor, Navocaftor, and ABBV-576 in Healthy Adults for the Treatment of Cystic Fibrosis
Cystic Fibrosis (CF) is a rare, life-threatening, genetic disease that affects the lungs and digestive system, significantly impairing the quality of life, with those affected having a median age of death at 40.
- Trial name
- ABBV-576 DDI (NCT05530278)
- Testing
- Galicaftor, ABBV-576, Navocaftor
- Where
- 4 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AbbVie
Cystic Fibrosis, Chronic Respiratory Failure
Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure.
There is no randomised controlled trials to determine the clinical effects of long term Non-Invasive Ventilation in Cystic Fibrosis patients.
- Trial name
- NCT00208078
- Testing
- pressure support ventilator
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Cochin Hospital
Pancreatic Cancer
TCR-T Cell Therapy on Advanced Solid Tumors
The primary aim of this study is to evaluate the efficacy of KRAS mutant antigen specific TCR-T cells in the treatment of patients with advanced solid tumors.
- Trial name
- NCT05438667
- Testing
- TCR-T therapy
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
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