Clinical trials: Pancreas-kidney Transplantation
Hepatitis C, Kidney Transplant; Complications
A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients
This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.
- Conditions
- Hepatitis C, Kidney Transplant; Complications, Heart Transplant Infection
- Trial name
- NCT04508907
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mayo Clinic
Simultaneous Pancreas-kidney Transplantation, Diabetic Cardiomyopathy
Assessment of Myocardial Injury in Simultaneous Pancreas and Kidney Transplantation
Diabetic cardiomyopathy( DCM) is a major complication of diabetes and is a common cardiovascular complication independent of coronary artery disease and hypertension．Trial to assess of myocardial injury in recipients of…
- Trial name
- AMI-SPK (NCT03904485)
- Testing
- cardiac magnetic resonance(CMR) T2 mapping
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin First Central Hospital
Pancreas Transplantation, Kidney Transplantation
A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids
Experience with tacrolimus in pancreas transplantation has become a standard for immunosuppression in almost all pancreas centers over the world.
- Trial name
- NCT00693446
- Testing
- Sirolimus, Tacrolimus
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Nantes University Hospital
Renal Transplantation, Kidney-pancreas Transplantation
Interstitial Lung Abnormalities in Renal Transplant Recipients
Immunosuppressive drugs such as tacrolimus, cyclosporine, mycophenolate mofetil, sirolimus and everolimus may have toxic pulmonary effects, particularly interstitial alterations.
- Trial name
- LCRT (NCT01017757)
- Testing
- High-resolution CT scanning
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- University of Parma
Diabetes Mellitus, Type 1
Sirolimus vs Mycophenolate With Tacrolimus in Simultaneous Pancreas and Kidney Transplantation
This is prospective randomized open single center clinical study to compare effect of sirolimus vs mycophenolate tacrolimus based protocol on pancreas and kidney graft survival in simultaneous pancreas and kidney recipients.
- Trial name
- NCT03582878
- Testing
- Sirolimus Oral Product, Mycophenolate Mofetil
- Where
- Czechia
- Volunteers
- 238 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Transplant; Complication, Rejection
Assessing Benchmarks For Allosure And Allomap Testing in Simultaneous Kidney & Pancreas Transplant Recipients.
This is a non-randomized, non-interventional, prospective pilot cohort study to monitor SPK patients post-transplant to determine if non-invasive measures using dd-cfDNA (Allosure) and AlloMap can assess an array of immune panels…
- Trial name
- SPKCareDx (NCT04855422)
- Testing
- Allosure, AlloMap
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Montefiore Medical Center
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Blood Coagulation
Thromboelastography and Pancreas-kidney Transplantation
Type of study:Prospective, single-center, non-therapeutic, of routine care No randomization, no modifications of the usual care, study results are not available for the physicians in charge of the patient.
- Trial name
- TEG-PKT (NCT02385006)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Hospices Civils de Lyon
Exocrine Pancreatic Insufficiency, Weight Gain
Role of Pancreatic Exocrine Secretion in Weight Gain After Pancreas Transplantation
Pancreas transplantation is currently the most reliable method for glycemic control in insulin dependent diabetic patients. Outcomes of pancreas transplantation have improved significantly over the years due to improved surgical…
- Trial name
- NCT04690738
- Testing
- Fecal Elastase Concentration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rush University Medical Center
Simultaneous Pancreas-Kidney Transplantation
To Explore the Value of Magnetic Resonance Imaging in Noninvasive Quantitative Evaluation of Graft Function After Simultaneous Pancreas-kidney Transplantation
Pancreatic kidney joint transplantation (SPK) has become the standard treatment for patients with diabetes complicated by end-stage renal disease.
- Trial name
- NCT07001917
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhen Li
Pancreas Transplant, Type 1 Diabetes Mellitus
Pancreas Transplant Alone in Uremia and Non-uremia Patients
Theoretically, pancreas transplant alone in uremia (PTAu) or pancreas before kidney transplant (PBK) may be considered for patients awaiting both pancreas and kidney grafts, alongside options like simultaneous pancreas-kidney…
- Conditions
- Pancreas Transplant, Type 1 Diabetes Mellitus, Uremia
- Trial name
- PTAu (NCT07872800)
- Testing
- pancreas transplant
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pancreas-kidney Transplantation, Kidney Transplantation
Bile Acids and Incretins in Pancreas Kidney Transplant Patients
Pancreas Kidney Transplantation (PKT) is the prominent treatment for type 1 diabetic patients with chronic kidney disease and improves patients' outcome.
- Trial name
- ITABI (NCT02234349)
- Testing
- pancreas kidney transplantation, kidney transplantation
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
CMV Disease, Viral Resistance
Long Term Use of Valganciclovir for Prophylaxis of CMV Disease in Kidney and Pancreas Transplant Patients
CMV viral disease negatively affects transplant patients. CMV is the most prevalent infection in transplant patients and 3 month drug regimens to prevent the virus have been mostly unsuccessful, usually after the drug has been…
- Conditions
- CMV Disease, Viral Resistance, Rejection, Death
- Trial name
- NCT00225394
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Massachusetts, Worcester
HIV, Kidney Transplant
Impact of Everolimus on HIV Persistence Post Kidney or Liver Transplant
Zortress (everolimus), the 40-O-(2-hydroxyethyl)-derivative of rapamycin, is an mTOR inhibitor approved for rejection prophylaxis in kidney transplant recipients.
- Conditions
- HIV, Kidney Transplant, Liver Transplant
- Trial name
- HIVTR-EVE (NCT02429869)
- Testing
- everolimus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Kidney-Pancreas Transplantation
Prograf-Advagraf Cross Over Conversion Study
The present study is aimed at evaluating the impact of a switch from Prograf to Advagraf on renal function, trough tacrolimus levels, drug-related adverse effects and adherence in stable recipients of kidney-pancreas transplants.
- Trial name
- NCT01797341
- Testing
- Tacrolimus
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Type 1
UVA Islet Cell Transplantation in Patients With Type I Diabetes
This protocol will provide islet cell transplantation to two separate populations in need of a pancreas transplant: Group I: Islet Cell Transplantation in Type I Diabetics without Kidney Problems Group II: Islet Cell…
- Trial name
- NCT00605592
- Testing
- Pancreatic Islets of Langerhans Cell Transplant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Cytomegalovirus
The Impact of Cytogam® on Time to Viral Load Reduction in Kidney or Kidney/Pancreas Transplant Recipients With Clinical CMV Disease
This pilot study is to assess whether using CytoGam® in combination with ganciclovir is more effective in reducing the CMV viral load over time, as compared to standard treatment with IV ganciclovir only.
- Trial name
- NCT00214240
- Testing
- CMV Immune globulin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Type 2, Overweight
Combined Bariatric Surgery and Pancreas After Kidney Transplantation for Type II Diabetics
The goal of this clinical trial is to evaluate the effectiveness of sleeve gastrectomy combined with pancreas after kidney (PAK) transplantation as a means of achieving normoglycemia, insulin independence, reduced insulin…
- Trial name
- ComB-PAK (NCT05576116)
- Testing
- Sleeve Gastrectomy AND Pancreas after Kidney Transplantation (Staggered Approach), Combined Sleeve Gastrectomy and Pancreas transplantation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Rejection; Transplant, Kidney, Rejection; Transplant, Pancreas
A Multicenter Randomized Controlled Trial to Treat Acute T Cell Mediated Rejection in Kidney and Kidney-Pancreas Transplant Recipients
After a kidney or a kidney-pancreas transplant, some patients may face problems with their new organs. This happens because the body sometimes makes a mistake and tries to get rid of the organ. This problem is called rejection.
- Trial name
- TACKLE-IT (NCT06474273)
- Testing
- Methylprednisolone, Prednisone
- Where
- 30 sites in Australia, Canada and 1 more
- Volunteers
- 540 people
- Sponsor
- University of Sydney
End Stage Renal Disease, Myocardial Microvascular Disease
Myocardial Microvascular Disease in ESRD
Cardiovascular diseases are the leading cause of mortality in patients with end stage renal disease (ESRD). They often have myocardial ischemia (a major predictor of mortality) on non invasive testing (Stress echocardiography…
- Trial name
- MICROCARD (NCT01291771)
- Testing
- Invasive FFR + CFR measurements are performed during coronary angiography using a pressure guide wire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon