Clinical trials: Pancreas-kidney Transplantation
Pancreas Transplant Rejection, Kidney Transplant Rejection
Donor-Derived Cell-Free DNA for Surveillance in Simultaneous Pancreas and Kidney Transplant Recipients
The AlloSure test is approved by the Centers for Medicare \& Medicaid Services (CMS) for use in Medicare patients to assess the probability of allograft rejection in kidney transplant patients.
- Trial name
- NCT04130685
- Testing
- Allosure Test
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Rush University Medical Center
Awaiting Organ Transplant, Infection in Solid Organ Transplant Recipients
Cell Mediated Immunity With Risk of Cytomegalovirus (CMV) in Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common infection with 60-90% of all adults worldwide having evidence of having the infection at sometime in their life.
- Trial name
- ViracorCMI (NCT01558037)
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Michael Ison
Diabetes Mellitus
Studies of Organ Transplantation in Animals and Man
A. To study the effects of pancreas transplantation (PT) on the structural abnormalities of diabetic nephropathy (DN) in patients with type 1 (insulin-dependent) diabetes mellitus (type 1 D).
- Trial name
- NCT00156364
- Where
- United States
- Volunteers
- 655 people
- Sponsor
- Michael Mauer, MD
Diabetes Mellitus；Uremia
Clinical Analysis of Simultaneous Pancreas-kidney Transplantation for End-stage Renal Disease Associated With Diabetes Mellitus
The first pancreas transplantation was performed in 1966, by 2015, more than 40,000 pancreas transplantation have been performed worldwide.
- Trial name
- NCT05497232
- Testing
- simultaneous pancreas-kidney transplantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Organ Transplantation
A Facilitated Access Program to Provide Everolimus (RAD) Maintenance for Patients Completing Therapy in RAD Trials in Solid Organ Transplantation
Facilitated access to everolimus until it is commercially available and reimbursable by appropriate parties
- Trial name
- NCT00149981
- Testing
- everolimus (RAD)
- Where
- 153 sites in United States, Australia and 17 more
- Sponsor
- Novartis Pharmaceuticals
Pancreas-Kidney Transplantation
Simultaneous Pancreas-kidney Transplantation With Campath Protocol
The purpose of this study is to determine and compare the efficacy of Campath-1H/Tacrolimus versus ATG/Tacrolimus/MMF therapy in conjunction with initial short-term steroids in Type 1-diabetic patients undergoing simultaneous…
- Trial name
- NCT00316810
- Testing
- Alemtuzumab, Rabbit Anti-Human Thymocyte Globulin
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Dr. Claudia Bösmüller
Renal Failure Chronic Requiring Dialysis, Diabetes Mellitus, with Complications
Magnesium Supplementation in Simultaneous Pancreas-Kidney Transplantation
Magnesium is essential in human physiology. Simultaneous pancreas-kidney (SPK) transplant recipients frequently experience hypomagnesemia. The effects of hypomagnesaemia are harmful.
- Conditions
- Renal Failure Chronic Requiring Dialysis, Diabetes Mellitus, with Complications, Glomerulosclerosis, Pancreatic Insufficiency (Exocrine and Endocrine)
- Trial name
- NCT06766786
- Testing
- Magnesium Sulfate high dose
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Dr Olu Bamgbade, MD, FRCPC
Diabetes Mellitus
Modification of the "Edmonton Protocol" to Allow for Successful Islet Transplantation From a Single Pancreas and Extension of the "Edmonton Protocol" to Kidney Transplant Recipients
The experience of the Edmonton Group with islet transplantation and use of the "Edmonton Protocol" provides much promise for T1DM patients.
- Trial name
- NCT00021580
- Testing
- human cadaveric islet cell transplantation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Gadolinium Toxicity
In Vitro Study of the Effect of Gadolinium Contrast on Fibrocytes
Gadolinium contrast agents are frequently administered for MRI imaging. Very little is known of its toxicity outside of patients with reduced renal function.
- Trial name
- NCT02512796
- Testing
- Gadolinium contrast dye
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Renal Insufficiency
Effects of Zoledronic Acid Versus Alendronate on Bone Loss After Kidney and Kidney/Pancreas Transplants
The study is designed to look at the effect of different bone treatment plans on bone loss after kidney or kidney/pancreas transplant.
- Trial name
- NCT00580047
- Testing
- Zoledronic Acid, Calcium with vitamin D, Alendronate
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Nebraska
Diabetes Mellitus, Type 1, Diabetic Nephropathy
European Trial of Immunosuppression in SPK Tx
1. To determine and compare the efficacy of Tacrolimus/Rapa versus Tacrolimus/MMF-based immunosuppression (in conjunction with initial short-term steroids and polyclonal antibody administration) in Type 1-diabetic patients…
- Trial name
- NCT00140543
- Testing
- sirolimus versus mycophenolate mofetil
- Where
- 14 sites in Austria, Belgium and 5 more
- Volunteers
- 228 people
- Sponsor
- EUROSPK Study Group
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Kidney Pancreas Transplant
Allosure in Simultaneous Pancreas Kidney Transplant
This study will observe donor derived cell free DNA percentages (via the Allosure test) in combined kidney-pancreas transplant recipients to establish both stable and dysfunctional Allosure assay levels
- Trial name
- NCT04777617
- Testing
- DD-cfDNA
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Heart Cancer, Kidney Cancer
Cancer Development In Organ Transplant Recipients
The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis.
- Conditions
- Heart Cancer, Kidney Cancer, Lung Cancer, Pancreas Cancer
- Trial name
- NCT02333279
- Where
- Switzerland
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Simultaneous Kidney and Pancreas Transplantation
Optimization of NULOJIX® Usage Towards Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation
The purpose of this study is to find out if the drug NULOJIX® (belatacept) will minimize the amount of other anti-rejection medications necessary and thereby reduce the long-term side effects caused by the other medications.
- Trial name
- NCT01790594
- Testing
- Belatacept, methylprednisolone, Anti-thymocyte Globulin (Rabbit)
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant Failure and Rejection
Using the Speckle Doppler to Quantify Blood Flow in Kidney and Pancreas Grafts
Kidney and Pancreas transplantation is considered the treatment of choice for many people with End Stage Renal Disease and Type 1 diabetes because quality of life and survival is often better after transplantation.
- Trial name
- NCT04202237
- Testing
- Speckle Doppler imaging, Blood sample
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Manchester University NHS Foundation Trust