Clinical trials: Pancreatectomy
Venous Thrombosis, Pulmonary Embolism
Deep Venous Thrombosis After Hepatobiliopancreatic Surgery
To investigate the incidence of pre- and early postoperative deep venous thrombosis in patients undergoing hepatobiliopancreatic surgery, as well as potential corresponding risk factors with special attention to circulating tumor…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Hepatectomy, Pancreatectomy
- Trial name
- POPLITEA (NCT02649023)
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Technische Universität Dresden
Pancreatectomy, Augmented Reality
Feasibility and Effectiveness of Augmented Reality Assistance System for Pancreatic Surgery
Pancreatic cancer necessitates surgical resection for complete tumor eradication, serving as the primary curative approach. However, pancreatic surgery is still challenging due to the organ's retroperitoneal anatomy and proximity…
- Trial name
- ARAS-P (NCT06208579)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Klinikum Saarbrücken, Klinik für Allgemein-, Viszeral- und Thoraxchirurgie, Chirurgische Onkologie
Pancreatectomy, Distal Pancreatectomy (DP)
Laparoscopic Versus Robot-assisted Left-sided Pancreatectomy for Benign and Pre-malignant Lesions (DIPLOMA-3)
The DIPLOMA-3 trial is an international, multicenter, patient-blinded randomized controlled trial comparing laparoscopic and robot-assisted left-sided pancreatectomy.
- Conditions
- Pancreatectomy, Distal Pancreatectomy (DP), Pancreatic Neoplasms, Pancreatic Adenoma
- Trial name
- DIPLOMA-3 (NCT06939023)
- Testing
- Laparoscopic minimally invasive left-sided pancreatecomy, Robot-assisted minimally invasive left-sided pancreatecomy
- Where
- Netherlands
- Volunteers
- 256 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Cancer, Pancreatic Neoplasms
Monitoring of patIents With Microdialysis Following Pancreaticoduodenectomy
A pancreaticoduodenectomy is performed in patient with pancreatic cancer. The most common and serious complication is leakage between the intestine and the remnant pancreas after this procedure. It occurs in 20-30%.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Biliary Tract Cancer, Duodenal Cancer
- Trial name
- MINIMUM (NCT03631173)
- Testing
- Surgical og radiological intervention, antibiotics
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Oslo University Hospital
Diabetes Mellitus
Study on Pancreatic Islets in Patients Undergoing (Partial) Pancreatectomy (PRECISE)
The study investigates the mechanisms underlying the pathogenesis of diabetes by examining structural and functional properties of islets of Langerhans in pancreas specimen from patients undergoing (partial) pancreatectomy.
- Trial name
- PRECISE (NCT06150690)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- German Diabetes Center
Pancreatic Ductal Adenocarcinoma (PDAC)
European Appleby Registry for Pancreatic Cancer
The EURO-APPLEBY Registry is a prospective, multicenter European observational registry designed to characterize contemporary surgical practice and evaluate perioperative and long-term oncological outcomes in patients undergoing…
- Trial name
- EURO-APPLEBY (NCT07889180)
- Volunteers
- 100 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Pancreatic Carcinoma
Repeat Quadratus Lumborum Block to Reduce Opioid Need in Patients After Pancreatic Surgery
This phase II trial studies how an additional anesthetic nerve block, called a quadratus lumborum block, works to reduce the need for opioids in patients after pancreatic surgery.
- Trial name
- NCT03745794
- Testing
- Best Practice, Quadratus Lumborum Block, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- M.D. Anderson Cancer Center
Diabetes
Dexcom G6 for Total Pancreatectomy With Islet Autotransplantation (TPIAT) Patients
A single-center prospective trial on the effects of standard of care radiation exposure on the Dexcom G6 continuous glucose monitoring (CGM) device.
- Trial name
- NCT05607576
- Testing
- Uncovered CGM during radiologic procedures
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Deborah Elder
Distal Pancreatectomy
Pancreatic Stent for Distal Pancreatectomy
The purpose of this study is to compare outcomes of patients undergoing distal pancreatectomy with or without pancreatic stent
- Trial name
- NCT03314337
- Testing
- Pancreatic stent: PSOF COOK®
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ruijin Hospital
Postoperative Hyperglycemia, Pancreatectomy
Postoperative Insulin Intervention After Pancreatectomy in nDM Patients
The goal of this randomized non-inferiority clinical trial is to evaluate whether routine postoperative insulin infusion can be safely omitted in preoperative non-diabetic adult patients undergoing pancreatectomy for…
- Trial name
- NCT07540975
- Testing
- Insulin Infusion, No Insulin Infusion (Standard Monitoring Only)
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Dae Wook Hwang
Pancreatectomy, Pancreatic Surgery
PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery
This study examines a new blood test called ICIS, which may help detect infections earlier after pancreatic surgery. Patients will have routine blood samples taken during their hospital stay, with no extra procedures required.
- Conditions
- Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
- Trial name
- PAN-ICIS (NCT07248527)
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic
Carcinoma, Pancreatic Ductal
Circulating Tumor Cells in Operative Blood
It is hypothesized that circulating tumor cells (CTCs) from pancreatic adenocarcinoma are released into the peritoneal cavity through blood lost during the surgical resection of these tumors resulting in peritoneal recurrence…
- Trial name
- NCT02150746
- Testing
- Peripheral/Central Venous Blood Draw, Peritoneal Wash
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Pancreatic Fistula, Pancreatic Neoplasms
Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
The study evaluates the safety and efficacy of Neoprene-based glue in the management of pancreatic stump after pancreatoduodenectomy (PD) in patients at high risk for pancreatic fistula and early neoplastic recurrence, compared…
- Conditions
- Pancreatic Fistula, Pancreatic Neoplasms, Postoperative Complications
- Trial name
- NCT03738787
- Testing
- Pancreatic duct occlusion with Neoprene, Pancreato-Jejunal anastomosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Pancreatectomy
Attachable Coolingbis® for Distal Pancreatectomy
This pilot study evaluates the safety and technical feasibility of a new radiofrequency-assisted device, the Attachable Coolingbis® (ACB), when used during robotic distal pancreatectomy.
- Trial name
- NCT07687901
- Testing
- Internally-cooled bipolar radiofrequency device
- Volunteers
- 20 people
- Sponsor
- Hospital del Mar
Pancreas; Fistula
Radiofrequency-assisted Transection of the Pancreas vs Stapler
Main objective: The main end-point of this study is to compare in a randomized clinical trial that radiofrequency-assisted pancreas transection (RF) reduces the incidence of postoperative pancreatic fistula (POPF) compared to the…
- Trial name
- TRANSPAIRE (NCT04402346)
- Testing
- Radiofrequency-assisted pancreas transection, Stapler assisted pancreas transection
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Patricia Sanchez Velazquez
Pancreatic Fistula
A Prospective Randomized Trial of Efficacy of Stump Closure for Distal Pancreatectomy
Overall morbidity rate remained high after distal pancreatectomy (DP), ranging from 30% to 60%. Whilst postoperative pancreatic fistula (POPF) remains serious and also is one of the most common complications after DP (12% to…
- Trial name
- NCT03201653
- Testing
- Stump closure using NU-KNIT SURGICEL
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Pancreatectomy; Hyperglycemia, Diabete Mellitus
Glucose Metabolism After Partial Pancreatectomy
This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.
- Trial name
- NCT04409171
- Testing
- oral glucose tolerance test
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pancreatic Neoplasms, Pancreatic Cancer
Indocyanine Green-Guided Versus Standard Laparoscopic Distal Pancreatectomy for Pancreatic Body and Tail Lesions
Postoperative pancreatic fistula is the most important complication after laparoscopic distal pancreatectomy for tumors of the body and tail of the pancreas. It can cause infection, bleeding, longer hospital stay, and even death.
- Trial name
- ICG-LDP (NCT07656571)
- Testing
- ICG Fluorescence-Guided Laparoscopic Distal Pancreatectomy, Standard Laparoscopic Distal Pancreatectomy
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Pancreatic Surgery, Pancreatic Duct Stenting
Pancreatic Stent to Prevent Leak After Distal Pancreatectomy
The purpose of this study is to investigate an intervention to prevent complications after pancreas surgery. The goal is to determine if placing a stent into the pancreatic duct before surgery will decrease or prevent leaking…
- Conditions
- Pancreatic Surgery, Pancreatic Duct Stenting, Pancreatic Cancer, Distal Pancreatectomy
- Trial name
- LEAPS (NCT00671463)
- Testing
- Pancreatic duct stenting
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Chronic Pancreatitis, Mesenchymal Stem Cells
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT
This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT).
- Trial name
- NCT05095532
- Testing
- Bone marrow-derived mesenchymal stem cells
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina