Clinical trials: Pancreatic Fibrosis
Cystic Fibrosis-related Diabetes
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases…
- Trial name
- NCT03650712
- Testing
- Oral glucose tolerance test, Continuous glucose monitoring, Dexa scan
- Where
- 4 sites in United States
- Volunteers
- 317 people
- Sponsor
- Katie Larson Ode
Cystic Fibrosis
Deposition of Inhaled Prolastin in Cystic Fibrosis Patients
The objective of this trial is to determine the optimal region of the lung for depositing Prolastin (alpha-1 antitrypsin; AAT) by inhalation in order to treat cystic fibrosis (CF).
- Trial name
- CF2 (NCT00486837)
- Testing
- Alpha1-Proteinase Inhibitor (Human)
- Volunteers
- 72 people
- Sponsor
- Grifols Therapeutics LLC
Cystic Fibrosis
STeP IT UP CF: STimulating ImProved Health And Well-being In CysTic Fibrosis
STeP IT UP CF: STimulating ImProved Health And Well-being In CysTic Fibrosis Using Integration Of Fitness Technology and Port CF.
- Trial name
- NCT04018495
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical College of Wisconsin
Cystic Fibrosis
1STST and Muscle Weakness in CF Patients
The investigators know that peripheral muscle weakness and exercise intolerance are prevalent (56%) in cystic fibrosis (Trooster et al, 2009). Physical inactivity is likely to be an important underlying factor.
- Trial name
- NCT03117764
- Testing
- Microfet Dynamometer, 1 minute sit to stand test, Accelerometer
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cystic Fibrosis, Non-CF Bronchiectasis
Regional Phenotyping of CF and Non-CF Bronchiectasis
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy…
- Trial name
- NCT04793867
- Testing
- Xenon
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis (CF)
Impact of Trikafta on P2X7R and Clinical Outcomes in Cystic Fibrosis
The aim of this study is to assess the response of the ETI on P2X7R level as inflammatory marker and clinical outcomes in patients with cystic fibrosis.
- Trial name
- NCT07841353
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Ain Shams University
Cystic Fibrosis, Pulmonary
Airway Clearance System (K031876) Phase IV Device Efficacy
Phase IV interventional study of adults (18 to 55) having a diagnosis of cystic fibrosis (mild, moderate or severe). The study is completely voluntary and is designed to measure participants use and the effectiveness of the…
- Trial name
- NCT03437811
- Testing
- Electro Flo Percussor, Model 5000
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mack Biotech, Corp.
Cystic Fibrosis
Study to Evaluate the Safety and Efficacy of CTP-656 in Patients With Cystic Fibrosis With CFTR Gating Mutations
This study will evaluate the efficacy and safety of CTP-656 in patients with cystic fibrosis (CF) who have a cystic fibrosis transmembrane conductance regulator (CFTR) gating mutation.
- Trial name
- NCT02971839
- Testing
- VX-561, IVA
- Where
- 14 sites in United States
- Volunteers
- 11 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis
Repeated Application of Gene Therapy in CF Patients
Cystic fibrosis is a genetic condition where epithelial cells, including from the respiratory tract, have an abnormal function of a surface protein, the cystic fibrosis transmembrane conductance regulator (CFTR) protein resulting…
- Trial name
- NCT01621867
- Testing
- pGM169/GL67A
- Where
- 3 sites in United Kingdom
- Volunteers
- 130 people
- Sponsor
- Imperial College London
Cystic Fibrosis, Pancreatic Insufficiency
Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI)
This is a Phase III, multicenter, open-label study, that will evaluate the improvement of nutrient absorption when participants will receive Ultrase® MT20. This study is sponsored by Aptalis (formerly Axcan).
- Trial name
- NCT00513682
- Testing
- Ultrase® MT20
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Forest Laboratories
Cystic Fibrosis, Chronic Respiratory Failure
Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure.
There is no randomised controlled trials to determine the clinical effects of long term Non-Invasive Ventilation in Cystic Fibrosis patients.
- Trial name
- NCT00208078
- Testing
- pressure support ventilator
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Cochin Hospital
Lung Infection
Detecting Lung Infections Through Vibration
The purpose of this study is to test a lung air vibrator device for vibrating air inside the lung. This exploratory diagnostic trial will test a novel and non-invasive means of detecting lower airway infections using exhaled…
- Trial name
- NCT02056860
- Testing
- Group 1 will receive 15 Hz, Group 2 will receive 30 Hz, Group 3 will receive 60 Hz
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cystic Fibrosis
Upper Extremity Exercise Capacity, Muscle Oxygenation, Balance in Patients With Cystic Fibrosis
The primary aim of the study is to evaluate upper extremity exercise capacity, muscle oxygenation, balance and physical activity level in patients with cystic fibrosis..
- Trial name
- NCT04803643
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Cystic Fibrosis
Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRI
This is an observational study for children with Cystic Fibrosis (CF) who are eligible based on their CF gene type. One group will be called the treatment group because they have the gene type (homozygous F508del) that makes them…
- Trial name
- NCT02848560
- Testing
- Hyperpolarized Xenon
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis
Pharmacokinetics of GLPG2737 in Male Subjects With Cystic Fibrosis
This is a single dose, open label study in adult male subjects with cystic fibrosis to investigate the pharmacokinetics, safety and tolerability of GLPG2737.
- Trial name
- NCT03450720
- Testing
- GLPG2737 single dose
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Lakefront Biotherapeutics NV
Cystic Fibrosis
Structure and Function of Salivary Proteins
This study seeks to provide point-of-care clinical diagnostic systems for the diagnosis of current disease status using saliva as a sample specimen.
- Trial name
- NCT00916682
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- Boston Children's Hospital
Pulmonary Failure, Cystic Fibrosis
Non-respiratory Comorbidities Observed in Pulmonary French Transplant Patients With Cystic Fibrosis
Pulmonary transplantation is the reference treatment for chronic terminal respiratory failure in patients with cystic fibrosis. These are mainly bi-pulmonary transplants (cardiopulmonary transplants are exceptional).
- Trial name
- MUCO TRANSPLAN (NCT03357913)
- Testing
- Lung transplantation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Cystic Fibrosis
Biomarkers of Injury and Destruction in the Cystic Fibrosis Lung
Cystic fibrosis (CF) is the most common autosomal recessive genetic disease in Caucasians. It results in lung disease that affects quality of life and causes early death.
- Trial name
- NCT01805713
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Asthma
Single Dose Study to Evaluate the Safety, and Efficacy of S-1226 (8%) in Subjects With Mild Atopic Asthma
Evaluate the safety and tolerability of a single dose of S-1226 (8%) in subjects with mild atopic asthma.
- Trial name
- S-1226(8%) (NCT02334553)
- Testing
- S1226(8%)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- SolAeroMed Inc.
Eye Manifestations
Ocular Surface Changes in Patients With Cystic Fibrosis
Cystic fibrosis(CF) is an inherited disease affecting children, adolescents and young adults with dysfunction of secretory glands.It is caused by mutations in the protein-coding gene which function as the cystic fibrosis…
- Trial name
- NCT00345280
- Testing
- impression cytology, obtain the tear fluid
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
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