Clinical trials: Pancreatic Fibrosis
Cystic Fibrosis
Safety and Tolerability Study of Liquid Alpha1 Proteinase Inhibitor (API) in Subjects With Cystic Fibrosis
Study to assess safety and tolerability of a single dose of study-drug administered to Cystic Fibrosis (CF) patients.
- Trial name
- NCT01347190
- Testing
- CR002 Liquid API
- Where
- 11 sites in Bulgaria, Hungary and 2 more
- Volunteers
- 25 people
- Sponsor
- CSL Behring
Cystic Fibrosis
Vitamin K Supplementation to Reduce Deficiencies in Adults With Cystic Fibrosis
Cystic fibrosis (CF) patients are at risk for vitamin K deficiencies. Supplementation for fat-soluble vitamins A, D, and E is well established, but in CF, there is little data for vitamin K concerning the optimal dose and…
- Trial name
- VITK-FK (NCT04496921)
- Testing
- Vitamin K supplementation, dose #1, Vitamin K supplementation, dose #2
- Where
- 2 sites in Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Cystic Fibrosis
Electrical Impedance Imaging of Patients With Cystic Fibrosis
The goal of this feasibility study is to evaluate the ability of Electrical Impedance Tomography (EIT) for providing regional and quantitative information about the extent and nature of bronchial obstruction in patients with…
- Trial name
- NCT02524704
- Testing
- CT scan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Cystic Fibrosis
Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis.
It is hypothesized that the inhalation of sodium pyruvate will reduce lung damage in patients with Cystic Fibrosis (CF) by its ability to reduce levels of toxic reactive oxygen and nitrogen compounds associated with the chronic…
- Trial name
- NCT00308243
- Testing
- Sodium Pyruvate in 0.9% Sodium Chloride Solution
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Emphycorp
Breast Cancer
Women At Risk: The High Risk Breast Cancer Program
The purpose of this study is to increase understanding of women who are at high risk for developing breast cancer. Data from this group will be collected and entered into a registry.
- Trial name
- WAR (NCT01034891)
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- New York Presbyterian Hospital
Cystic Fibrosis
Effect of a Nursing Program for Patients With Cystic Fibrosis on Disease Management
The purpose of this study is to evaluate the effect of a nursing program in patients with cystic fibrosis.
- Trial name
- NCT02286050
- Testing
- CF Nursing Program
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University of Zurich
Cystic Fibrosis, Exocrine Pancreatic Insufficiency
Assessment of a PERT-free Nutritional Therapeutic Delivery System for Cystic Fibrosis
This is a single center, randomized, double-blind, cross-over trial (with a follow-on single-blind safety evaluation stage), assessing a ready-to-drink nutritional supplement used without PERT ("PERT-free"), nutritional…
- Trial name
- NCT04966897
- Testing
- Standard Nutritional Supplement + PERT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- GlycosBio, Inc.
Cystic Fibrosis
Airway Clearance Using High Frequency Chest Wall Oscillation
High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucous clearance compared with control. These observations led to the development of 'The Vest' which is a non-stretchable jacket connected to an…
- Trial name
- NCT00817947
- Testing
- High frequency chest wall oscillation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cystic Fibrosis
A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation
The purpose of this study is to evaluate the efficacy and safety of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants who are homozygous for F508del, heterozygous for F508del and a gating (F/G) or residual…
- Trial name
- NCT05076149
- Testing
- VX-121/TEZ/D-IVA, ELX/TEZ/IVA, IVA
- Where
- 170 sites in United States, Australia and 18 more
- Volunteers
- 597 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis (CF), CFTR Gene Mutation
Cystic Fibrosis in the Kidney: Monitoring the Effectiveness of Elexacaftor/tezacaftor/ivacaftor in Urine After a Short Pause of Therapy
In cystic fibrosis (CF) renal base excretion is impaired, due to mutations in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene, since CFTR function is crucial in regulation of the kidney's HCO3- excretion.
- Trial name
- NCT05818319
- Testing
- 12 hours ETI pause, 36 hours ETI pause, 60 hours ETI pause
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Cystic Fibrosis
Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation
The purpose of this study to investigate the effect of sulforaphane from macerated broccoli sprouts in humans and to evaluate less invasive methods of assessing potential anti-inflammatory drugs in CF.
- Trial name
- NCT01315665
- Testing
- Broccoli sprouts
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cystic Fibrosis
Safety and Feasibility of High-intensity Interval Training Program in CF Patients
This study compare an usual training program (in continuous endurance) with an ITHI program over a period of 3 weeks, in France.
- Trial name
- ITHI (NCT04888767)
- Testing
- Interval Training Hight Intensity Program
- Where
- 2 sites in France
- Volunteers
- 62 people
- Sponsor
- Fondation Ildys
Cystic Fibrosis
A Phase IIb Study of OligoG in Subjects With Cystic Fibrosis
The purpose of the study is assessment of efficacy and safety of OligoG as a dry powder formulation, in adult subjects with cystic fibrosis.
- Trial name
- SMR-2984 (NCT02157922)
- Testing
- alginate oligosaccharide
- Where
- 18 sites in Denmark, Germany and 3 more
- Volunteers
- 65 people
- Sponsor
- AlgiPharma AS
Cystic Fibrosis
Phase II Study of Digitoxin to Treat Cystic Fibrosis
This study will measure the inflammatory effects of digitoxin on IL-8 and neutrophil counts in induced sputum in stable Cystic Fibrosis (CF) patients and the pharmacokinetics of digitoxin in serum. Funding Source-FDA OOPD
- Trial name
- NCT00782288
- Testing
- digitoxin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Jewish Health
Cystic Fibrosis (CF), Cystic Fibrosis Lung Disease
SPutum Induction and Nebuliser deviCEs for Patients With CF
The goal of the SPICE-CF feasibility trial is to learn whether it is feasible to recruit and retain people with cystic fibrosis (CF) who are unable to produce sputum spontaneously in a study comparing two different nebuliser…
- Trial name
- SPICE-CF (NCT07879651)
- Testing
- Sputum induction
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cystic Fibrosis
COVID-19 Antibody Responses In Cystic Fibrosis
Coronavirus disease 2019 (COVID-19) which is caused by the virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in an ongoing global pandemic.
- Trial name
- CAR-CF (NCT05158829)
- Where
- 6 sites in Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cystic Fibrosis
Canadian Observational Study Evaluating the Long-term IMPACT of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators on People With CF
This observational study intends to investigate health trends and data in cystic fibrosis patients all across Canada that are receiving modulator treatment so researchers can determine if CFTR treatments are effective over a long…
- Trial name
- Can-IMPACT CF (NCT05200429)
- Testing
- Trikafta
- Where
- 2 sites in Canada
- Volunteers
- 500 people
- Sponsor
- University of British Columbia
Cystic Fibrosis
Effect of Andecaliximab on FEV1 in Adults With Cystic Fibrosis
The primary objective of this study is to evaluate the effect of andecaliximab (GS-5745) on pre-bronchodilator forced expiratory volume in 1 second (FEV1) % predicted in adults with cystic fibrosis (CF) after 8 weeks of…
- Trial name
- NCT02759562
- Testing
- Andecaliximab
- Where
- 5 sites in Australia, France and 3 more
- Volunteers
- 6 people
- Sponsor
- Gilead Sciences
Cystic Fibrosis
Inhaled Mannitol on Mucociliary Clearance in Moderate to Severe Cystic Fibrosis
This study will provide important mechanistic information regarding the effect of inhaled mannitol (Bronchitol) in people with cystic fibrosis (PwCF) with moderate to severe disease who are already using…
- Trial name
- NCT05740618
- Testing
- Mannitol Inhalant Product
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis, Lung Diseases
Trikafta Exercise Study in Cystic Fibrosis
Shortness of breath (dyspnea) during exercise is a major source of distress and is a commonly reported symptom in patients with cystic fibrosis (CF).
- Trial name
- NCT05279040
- Testing
- Trikafta
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
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