Clinical trials: Pancreatic Fibrosis
Cystic Fibrosis
Exploring Novel Interventions to Improve Adherence in Children With Cystic Fibrosis
The investigators know that adherence to medications in children with cystic fibrosis (CF) is poor. Forgetfulness has often been reported as a barrier to adherence by both CF patients and their parents.
- Trial name
- NCT02301377
- Testing
- Spiro PD personal spirometer
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Cystic Fibrosis, Cystic Fibrosis in Children
Feasibility of a Mobile Medication Plan Application in CF Patient Care
This is a pilot, multicenter, prospective, randomized controlled study to evaluate the feasibility of an innovative medication adherence intervention utilizing a web-based, mobile medication management application [MedActionPlan®…
- Trial name
- MAP (NCT03637504)
- Testing
- MedActionPlan®
- Where
- 5 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cystic Fibrosis, Asthma
Project 2 Airway Potential Hydrogen (pH) in Asthma
This study is testing a non invasive way to measure airway pH in individuals with Asthma and Cystic Fibrosis using a new inhaled drug.
- Conditions
- Cystic Fibrosis, Asthma, Severe Persistent Asthma, Healthy
- Trial name
- NCT03617718
- Testing
- Glycine Buffer
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- Case Western Reserve University
Cystic Fibrosis
Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA TC Combination Therapy in Participants With Cystic Fibrosis Who Are 6 Years of Age and Older
The study evaluates the long-term safety, tolerability, efficacy, and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in participants with cystic fibrosis (CF).
- Trial name
- NCT04183790
- Testing
- ELX/TEZ/IVA, IVA
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 64 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis
Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis
OBJECTIVES: I. Compare the clinical status of pregnant vs non-pregnant women with cystic fibrosis. II. Determine glucose tolerance during each trimester of pregnancy in these women. III.
- Trial name
- NCT00014768
- Testing
- glucose, insulin, leucine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Cystic Fibrosis, Chronic Disease
Feasibility of a Goal-based Agenda Setting Intervention
This study aims to assess the feasibility of a new, brief intervention, the 'coopeRATE Prompt', for informing conversations between patients and physicians in routine tele-health and in-person adult Cystic Fibrosis (CF) care.
- Trial name
- NCT04696484
- Testing
- coopeRATE Prompt
- Where
- 4 sites in United States
- Volunteers
- 219 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cystic Fibrosis
Effects of an Individualized Exercise Program on Health-related and Skill/Performance-related fitness in CF.
The aim of this study is to evaluate the effects of a partially supervised exercise program on different aspects of physical fitness, despite VO2peak, lung function, quality of life and sleep quality in children, adolescents and…
- Trial name
- NCT03518697
- Testing
- exercise program
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital, Essen
Cystic Fibrosis
NETwork of Linoleic Acid Supplementation in Cystic Fibrosis
Undernutrition is a common problem in patients with cystic fibrosis (CF) despite international consensus that the patients shall be given 120-200% of energy recommendations.
- Trial name
- NETLACF (NCT04531410)
- Testing
- linoleic acid supplementation, oleic acid supplementation
- Where
- 3 sites in Italy, Norway and 1 more
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Cystic Fibrosis
Surrogate Markers of Response to New Therapies in Cystic Fibrosis Patients
The purpose of this study is to determine which biological marker, or association of biological markers, best predict clinical response of cystic fibrosis patients to CFTR modulators.
- Trial name
- BIO-CFTR (NCT02965326)
- Testing
- Nasal swab; rectal biopsy.
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Hôpital Necker-Enfants Malades
Breast Neoplasms, Germline BRCA1 Gene Mutation
Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery
Robotic mastectomy and immediate reconstruction have been introduced in 2015. However, since robotic mastectomy is the latest surgical technique, there is a lack of studies prospectively comparing conventional mastectomy and…
- Conditions
- Breast Neoplasms, Germline BRCA1 Gene Mutation, Germline BRCA2 Gene Mutation, Benign Breast Disease
- Trial name
- MARRES (NCT04585074)
- Testing
- Robotic or endoscopic nipple sparing mastectomy, Conventional mastectomy (including nipple sparing mastectomy, skin sparing mastectomy)
- Where
- 18 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Severance Hospital
Cystic Fibrosis
Magnetic Resonance Imaging and Neuro-Psychological Testing In Cystic Fibrosis
CF is a complex, inherited illness that can affect many organs of the body. The investigators have found that some patients with CF have reported more problems with memory than would be expected at their age and that patients…
- Trial name
- NCT04451213
- Testing
- MRI head
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Cardiff and Vale University Health Board
Cystic Fibrosis
Cystic Fibrosis Foundation (CFF) Biomarkers of Exacerbation
Clinical and translational research in cystic fibrosis (CF) is hampered by a lack of biomarkers that can be used to identify promising new therapies.
- Trial name
- NCT00788359
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis
Study of VX-121 in Healthy Subjects and in Subjects With Cystic Fibrosis
The purpose of this study is to evaluate safety and tolerability of VX-121 in healthy subjects and in subjects with cystic fibrosis (CF).
- Trial name
- NCT03768089
- Testing
- VX-121 (Suspension), TEZ/IVA, IVA
- Where
- 7 sites in Netherlands, United Kingdom
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Bronchiectasis Idiopathic, Cystic Fibrosis
WGS of Korean Idiopathic Bronchiectasis
Whole genome sequencing of Korean patients with idiopathic bronchiectasis and their family will perform to identify disease-causing variants.
- Conditions
- Bronchiectasis Idiopathic, Cystic Fibrosis, Primary Ciliary Dyskinesia
- Trial name
- WGS_UNK_BE (NCT03809091)
- Testing
- Whole genome sequencing
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Cystic Fibrosis-related Diabetes, Diabetes Mellitus
A Comparison of Clinical Parameters in With and Without Abnormal Glucose Tolerance.
Cystic fibrosis (CF) is autosomal recessive, genetic disorder cause of cystic fibrosis transmembrane regulatory (CFTR) gene mutation. CF often is observed in caucasian population.
- Conditions
- Cystic Fibrosis-related Diabetes, Diabetes Mellitus, Cystic Fibrosis
- Trial name
- NCT04503408
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Cystic Fibrosis
Evaluation of Sit-to-stand Test in Patients With Cystic Fibrosis and Matched Controls.
Introduction: In recent years, since the discovery of the cystic fibrosis (CF) transmembrane conductance regulator gene in human skeletal muscle, there appears to be growing interest in the measurement of muscle function in CF.
- Trial name
- STS-CF (NCT03524859)
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Cystic Fibrosis
Study About Complications of Totally Implanted Venous Access Devices (TIVADs) in People With Cystic Fibrosis (CF)
Pulmonary infections are the major cause of mortality and morbidity in cystic fibrosis (CF); patients frequently have to take antibiotics which often cannot be given orally or by aerosol but have to be administered intravenously.
- Trial name
- NCT00670579
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Florence
Cystic Fibrosis, Innate Immunity
Implication of UNconventionaL T Lymphocytes in Cystic Fibrosis (UNLOCk)
Cystic fibrosis (CF) is characterized by a decrease in mucociliary clearance, recurrent infections and airway inflammation. This inflammatory process in airway mucosa is persistent, uncontrolled, but, somewhat paradoxically…
- Conditions
- Cystic Fibrosis, Innate Immunity, Inflammatory Response
- Trial name
- UNLOCk (NCT03886350)
- Testing
- blood and sputum samples
- Where
- 2 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Tours
Cystic Fibrosis
Pre-flight Evaluation of Adult Patients With Cystic Fibrosis
The purpose of the study is to investigate the relationship between hypoxemia achieved during Hypoxia Altitude Simulation test and sea level values of pulmonary function, arterial blood gases, pulse oximetry and cardiopulmonary…
- Trial name
- NCT01569880
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Cystic Fibrosis
Comparison of Absorption of Vitamin D in Cystic Fibrosis
The investigators predict that a powder pill form of vitamin D will be more effectively absorbed than an oil form of vitamin D in people diagnosed with Cystic Fibrosis.
- Trial name
- NCT01880346
- Testing
- Vitamin D Powder, Vitamin D Oil
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Emory University
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