Clinical trials: Pancreatic Fibrosis
Cystic Fibrosis
Biomarkers of Iron Homeostasis and Responses to Cystic Fibrosis Pulmonary Exacerbation (CFPE) Treatment
The goal of this study is to identify chemical compounds in the blood and sputum (i.e., biomarkers) that are associated with objective measurements of health status in patients with cystic fibrosis (CF).
- Trial name
- NCT02188758
- Testing
- Adults - CFPE Treatment
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cystic Fibrosis - Complete
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.
The goal of this clinical trial is to evaluate the safety and tolerability of TMX in adults patients with cystic fibrosis who do not have mutations currently eligible for therapy with modulator drugs.
- Trial name
- TMX (NCT07289035)
- Testing
- Tamoxifen Citrate 20Mg Tab
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Interstitial Lung Disease, COPD
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as…
- Conditions
- Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- GUARDIANLUNG (NCT04930289)
- Testing
- LungGuard, BAROGuard
- Where
- 15 sites in United States, Belgium
- Volunteers
- 3,500 people
- Sponsor
- Paragonix Technologies
Cystic Fibrosis (CF)
Long Term Significance (Survival) of LCI in Patients With Cystic Fibrosis
The current dream in CF research is to discover safe drugs that correct the basic defect and prevent lung disease, allowing patients without significant lung damage to live nearly normal lives with a dramatic increase in life…
- Trial name
- NCT01951833
- Testing
- EasyOne Pro and Ecomedics
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Cystic Fibrosis
A Study to Determine the Variability of a 6-Minute Walk Test in Cystic Fibrosis Subjects With Advanced Lung Disease
This is an observational study to be conducted at approximately 25 sites in the United States. Approximately 25 subjects with severe obstructive CF lung disease (FVC <40% predicted) will be enrolled.
- Trial name
- NCT00311506
- Volunteers
- 25 people
- Sponsor
- Genentech, Inc.
Cystic Fibrosis
Comparison of Airway Clearance Therapy in Cystic Fibrosis Using the Same VEST Therapy Device But With Different Settings
Our primary hypothesis is that airway clearance therapy with sine waveform HFCWO using higher inflation pressures combined with both low and high oscillator frequencies will result in greater sputum production compared to sine…
- Trial name
- NCT00685035
- Testing
- HFCWC with higher pressure/variable-frequency settings, HFCWC with lower pressure/mid-frequency settings
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Minnesota
Cystic Fibrosis
Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease
This study is designed as a masked, two center, randomized, placebo-controlled pilot study to evaluate the safety and efficacy of nasal and oral inhalation of 75 mg aztreonam in subjects with CF and lung infection due to PA.
- Trial name
- NCT02730793
- Testing
- Oral Aztreonam, Nasal Aztreonam
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Cystic Fibrosis
Phase I Study of Liposome-Mediated Gene Transfer in Patients With Cystic Fibrosis
OBJECTIVES: Evaluate the efficacy and safety of lipid-mediated transfer of the cystic fibrosis transmembrane conductance regulator gene to nasal epithelium in patients with cystic fibrosis.
- Trial name
- NCT00004806
- Testing
- Cystic fibrosis transmembrane conductance regulator
- Volunteers
- 9 people
- Sponsor
- University of Alabama at Birmingham
Cystic Fibrosis
Study of INS37217 Inhalation Solution in Mild to Moderate Cystic Fibrosis Lung Disease
The purpose of this study is to assess the safety and effectiveness of multiple dosages of INS37217 compared to placebo over 28 days in subjects with mild to moderate cystic fibrosis (CF) lung disease.
- Trial name
- NCT00056147
- Testing
- denufosol tetrasodium (INS37217)
- Volunteers
- 90 people
- Sponsor
- Merck Sharp & Dohme LLC
Cystic Fibrosis
Metabolic Abnormalities in Hispanic Children With Cystic Fibrosis
Our specific aims include: 1. AIM 1. Characterization of glucose tolerance, nutritional and clinical status, socioeconomic status, family history of diabetes and genotype in Hispanic CF children compared to Caucasian CF children.
- Trial name
- NCT00287443
- Testing
- Oral Glucose tolerance test, Whole body protein turnover, IV glucose tolerance test
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Cystic Fibrosis
Effect of Hypertonic Saline on Mucus Clearance in Children Ages 5-12 With Cystic Fibrosis
Previous work demonstrated that inhaled hypertonic saline (HS) reduces exacerbation frequency and improves lung function in adults with cystic fibrosis (CF).
- Trial name
- NCT01031706
- Testing
- Hypertonic Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Pseudomonas Aeruginosa Infection, Cystic Fibrosis (CF)
Study With Phage for CF Subjects With Pseudomonas Lung Infection
The goal of this Phase 2b clinical trial is to see if nebulized phage (BX004) can treat chronic Pseudomonas aeruginosa (PsA) lung infection in CF subjects.
- Trial name
- NCT06998043
- Testing
- BX004
- Where
- 14 sites in United States
- Volunteers
- 63 people
- Sponsor
- BiomX Ltd
Cystic Fibrosis
Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis
Cystic fibrosis (CF) results in the thickening of mucus in the lungs and other organs due to dysfunction of a transmembrane conductance protein.
- Trial name
- NCT04467957
- Testing
- Initiation of CFTR Modulator, Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cystic Fibrosis
Study of Urinary Predictors of Exacerbations by Biomarkers in Cystic Fibrosis
Study of Urinary Predictors of Exacerbations by Biomarkers in Cystic Fibrosis
- Trial name
- SUPERB-CF (NCT04297709)
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Mologic Ltd
Non Cystic Fibrosis Bronchiectasis
HFCWO in Children With Non-CF Bronchiectasis
the study will concentrate on the effect of High Frequency Chest Wall Oscillation compared to conventional pulmonary physiotherapy on children with non cystic fibrosis bronchiectasis
- Trial name
- NCT07722364
- Testing
- High Frequency Chest Wall Oscillation, conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sphinx university
Cystic Fibrosis
Study of the Effect of Ivacaftor on Lung Clearance Index in Subjects With Cystic Fibrosis and the G551D Mutation
The purpose of this study is to evaluate the effect of ivacaftor (VX-770) on lung clearance index (LCI) in subjects aged 6 years and older with cystic fibrosis (CF) who have the G551D-CFTR mutation on at least 1 allele.
- Trial name
- NCT01262352
- Testing
- Ivacaftor
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 21 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pulmonary Cystic Fibrosis
Home Airway Clearance in CF Patients
Regular bronchial clearance is essential in patients with cystic fibrosis for their bronchial health. SIMEOX® (Physio-Assist, Aix en Provence, France) is an innovative medical device for the drainage of the bronchial tree.
- Trial name
- HomeCareSIMEOX (NCT04096664)
- Testing
- SIMEOX
- Where
- 20 sites in France
- Volunteers
- 143 people
- Sponsor
- Physio-Assist
Cystic Fibrosis
Clearing Lungs With Epithelial Sodium Channel (ENaC) Inhibition in Cystic Fibrosis (CF)
The goal of the study is to evaluate the safety and tolerability of P-1037 and to determine whether the combination of P-1037 with hypertonic saline or P-1037 alone has a greater effect on lung function in patients with CF than…
- Trial name
- CLEAN-CF (NCT02343445)
- Testing
- P-1037, Hypertonic Saline, Saline
- Where
- 33 sites in United States
- Volunteers
- 142 people
- Sponsor
- Parion Sciences
Cystic Fibrosis
FTIH - Single and Repeat Oral Doses of FDL169 in Healthy Volunteers
To determine the safety and tolerability of single and multiple escalating doses of FDL169 in healthy male subjects.
- Trial name
- NCT02359357
- Testing
- FDL169
- Where
- United Kingdom
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Flatley Discovery Lab LLC
Cystic Fibrosis
A Study Evaluating the Efficacy and Safety of VX-445/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects, Homozygous for F508del
This study will evaluate the efficacy, safety, and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are homozygous for…
- Trial name
- NCT04105972
- Testing
- ELX/TEZ/IVA, TEZ/IVA, IVA
- Where
- 35 sites in Australia, Belgium and 2 more
- Volunteers
- 176 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
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