Clinical trials: Pancreatic Fibrosis
Cystic Fibrosis Liver Disease, Pancreatic Insufficiency
MRI to Characterize and Predict CF Liver Disease in PUSH Cohort
Specific Aim 1. Determine if valid results of non-sedated MRI based assessments of liver stiffness and lipid content can be obtained in more than 90% of children and young adults with cystic fibrosis. Specific Aim 2.
- Trial name
- NCT02979340
- Testing
- MRI
- Where
- 8 sites in United States
- Volunteers
- 115 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cystic Fibrosis
PTC Study to Evaluate Ataluren in Combination With Ivacaftor
The purpose of this study is to explore the combination of ataluren and ivacaftor as a treatment for patients with nonsense mutation cystic fibrosis
- Trial name
- NCT03256968
- Testing
- Ataluren
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Cystic Fibrosis (CF)
Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of SION-719 when given to people with CF who are already taking Trikafta.
- Trial name
- PreciSION CF (NCT07108153)
- Testing
- SION-719
- Where
- 13 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Sionna Therapeutics Inc.
Cystic Fibrosis
Energy Balance and Weight Gain With Ivacaftor Treatment
Ivacaftor is a novel, FDA approved new therapy that addresses Cystic fibrosis transmembrane conductance regulator (CFTR) dysfunctions in subjects with Cystic fibrosis (CF) and "gating mutations".
- Trial name
- NCT02141464
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's Hospital of Philadelphia
Cystic Fibrosis, Burkholderia Infections
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis and Chronic Burkholderia Species Infection
The purpose of this research study was to determine if an experimental drug called Aztreonam for Inhalation Solution (AZLI) was safe and effective to treat Burkholderia lung infections in patients with cystic fibrosis (CF).
- Trial name
- NCT01059565
- Testing
- AZLI
- Where
- 35 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- Gilead Sciences
Cystic Fibrosis, Cystic Fibrosis in Children
Program Of Exercises During The Hospitalization Of Children And Adolescents With Cystic Fibrosis
The objective of this study was to evaluate the effect of a physical exercise program on the functional capacity of children and adolescents with cystic fibrosis hospitalized at the Hospital de Clínicas of Porto Alegre (HCPA)…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis in Children, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis With Exacerbation
- Trial name
- NCT03273959
- Testing
- Exercise protocol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis
Efficacy and Safety Study of Creon IR in Subjects With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
The objective of this study is to assess the efficacy and safety of different doses of Creon Immediate Release (IR) in comparison to Creon® 25,000 Delayed Release/Gastro-Resistant (DR/GR) in subjects with Pancreatic Exocrine…
- Trial name
- NCT02415959
- Testing
- Creon IR, Creon® (DR/GR)
- Where
- 17 sites in Czechia, Hungary and 2 more
- Volunteers
- 70 people
- Sponsor
- Abbott
Cystic Fibrosis, Adherence, Medication
Evaluation of the ReX-C System, in Patients Receiving CFTR Modulators for the Treatment of Cystic Fibrosis (CF).
Cystic fibrosis (CF) is a progressive multisystem disorder characterized by abnormalities in the transport of chloride ions in human airway epithelial cells, leading to frequent lung infections, decreased pulmonary function…
- Trial name
- NCT04215796
- Testing
- ReX-C system
- Where
- 2 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Dosentrx Ltd.
Cystic Fibrosis
Influence of a Residential Rehabilitation Program on Body Composition in Patients with Cystic Fibrosis
The aim is to evaluate the impact of a 3-week lasting residential rehabilitation program for patients with cystic fibrosis on their nutritional status measured as BMI and body composition and pulmonary function.
- Trial name
- NCT04527796
- Testing
- Rehabilitation
- Where
- Belgium
- Volunteers
- 39 people
- Sponsor
- University Hospital, Ghent
Cystic Fibrosis
Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation
The primary objective of the study was to evaluate the safety and tolerability of VX-809 in participants with cystic fibrosis (CF) who are homozygous for the F508del mutation on the CF transmembrane conductance regulator (CFTR)…
- Trial name
- NCT00865904
- Testing
- VX-809
- Where
- 25 sites in United States, Belgium and 3 more
- Volunteers
- 93 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis (CF)
Progressive Muscle Relaxation in Pulmonary Rehab for Quality of Life, Mental Health, and Sleep in Cystic Fibrosis
This study, called PRIME-CF, will look at how adding progressive muscle relaxation (PMR) to a typical pulmonary rehabilitation (PR) program might help adults with cystic fibrosis (CF).
- Trial name
- PRIME-CF (NCT06592742)
- Testing
- Pulmonary rehabilitation (alone), Intervention group (PR + PMR)
- Where
- Romania
- Volunteers
- 22 people
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Cystic Fibrosis
The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis
This study is examining the effect of hypertonic saline compared to placebo on the Lung Clearance Index in Cystic Fibrosis patients.
- Trial name
- NCT00635141
- Testing
- hypertonic saline (7 %) and isotonic saline (0.9%)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Prospective Intervention Study on Vitamin D in Patients With Cystic Fibrosis
The vast majority of Cystic Fibrosis (CF) patients worldwide are vitamin D insufficient. There is no evidence of benefit of vitamin D supplementation for CF patients yet.
- Trial name
- D-vitamin (NCT01321905)
- Testing
- Supplementation with vitamin D2/D3
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Karolinska Institutet
Cystic Fibrosis, Liver Fibroses
The Use of Novel Diagnostic Tools to Increase Detection of Early Fibrosis in Cystic Fibrosis Related Liver Disease to Improve Clinical Management
Cystic Fibrosis (CF) is a genetic condition which affects 1 in 2500 newborn infants and is the commonest genetic condition in the UK. 1 in 25 of the white population carry the mutation.
- Conditions
- Cystic Fibrosis, Liver Fibroses, Cystic Fibrosis Liver Disease
- Trial name
- NCT04277819
- Where
- United Kingdom
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Cystic Fibrosis, Bone Loss
CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis
Study is looking at the effects of cystic fibrosis treatment on bone muscle.
- Conditions
- Cystic Fibrosis, Bone Loss, Muscle Loss
- Trial name
- NCT04206436
- Testing
- Cftr Modulators
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Indiana University
Cystic Fibrosis, Bronchiectasis
Reaction Time and Postural Control in Individuals With Cystic Fibrosis and Bronchiectasis
The aim of this study is to evaluate the reaction time and postural control and to investigate the relationship between reaction time, exercise capacity, muscle oxygenation and balance in children with cystic fibrosis (CF) and…
- Trial name
- NCT03902236
- Testing
- Reaction Time and Postural Control, Muscle oxygenation, Exercise capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cystic Fibrosis, Hypoglycemia
Hypoglycemia and Glucagon Response in CF
The goal of this clinical trial is to investigate the etiopathogenesis of isolated hypoglycemia and hypoglycemia with abnormal glucose tolerance in children with Cystic Fibrosis (CF) and to evaluate the role of glucagon and…
- Conditions
- Cystic Fibrosis, Hypoglycemia, Glucagon Deficiency, Pancreatic Insufficiency
- Trial name
- NCT05700604
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cystic Fibrosis
Comparison of the Tolerability of Two Formulations of Hypertonic Saline in Cystic Fibrosis Patients
The purpose of this study is to compare the tolerability and acceptability of a formulation containing Hypertonic saline 7% (HS) alone and a formulation containing HS and Hyaluronic acid 0.1% in a population of Cystic Fibrosis…
- Trial name
- NCT01658449
- Testing
- Inhalable Hypertonic saline 7% + Hyaluronan 0.1%, Inhalable Hypertonic saline 7%
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Civile Ca' Foncello
Cystic Fibrosis
Bacteriophage Effects on Pseudomonas Aeruginosa
Pulmonary phage therapy to treat bacterial infections of the respiratory tract have been investigated in animals. The aim of the present study is to evaluate the efficacy of bacteriophages in infecting Pseudomonas aeruginosa (PA)…
- Trial name
- MUCOPHAGES (NCT01818206)
- Testing
- Collection of induced sputum in order to evaluate the efficacy of a cocktail of 10 bacteriophages.
- Where
- France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis
Cystic Fibrosis Remote Monitoring System
The objective of this study is to determine if interactive technology (i.e. virtual coaching) that facilitates vest therapy goal setting and provides positive reinforcement will increase adherence to vest therapy for airway…
- Trial name
- NCT04453358
- Testing
- InCourage-Connect, InCourage
- Volunteers
- 35 people
- Sponsor
- Koronis Biomedical Technologies
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