Clinical trials: Pancreatic Fibrosis
Breast Disease, Benign Breast Disease
Effectiveness Validation of CELBREA® in Symptomatic Women or With Diagnostic Doubt of Breast Pathology (DETECT-BH)
This is an observational, prospective, and transversal study, designed to evaluate the effectiveness of CELBREA® in women from the local community coming to consult at the Breast Pathology Unit of La Paz Hospital (Madrid, Spain)…
- Conditions
- Breast Disease, Benign Breast Disease, Breast Cancer
- Trial name
- DETECT-BH (NCT05857111)
- Testing
- Celbrea
- Where
- Spain
- Volunteers
- 255 people
- Sponsor
- Jose Ignacio Sánchez
Cystic Fibrosis, Parenthood Status
Health Outcomes of Parents With Cystic Fibrosis
This project will determine the health impact of parenthood on people with cystic fibrosis (CF). The study team will use retrospective data to provide relatively immediate evidence on parenthood's effect on pulmonary health.
- Trial name
- HOPeCF (NCT05829694)
- Testing
- Parental Status
- Where
- 8 sites in United States
- Volunteers
- 956 people
- Sponsor
- University of Pittsburgh
Cystic Fibrosis
International Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa
The purpose of this study was to evaluate the safety and efficacy of a 28-day course of aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis (CF) and lung infection due to Pseudomonas aeruginosa (PA).
- Trial name
- AIR-CF1 (NCT00112359)
- Testing
- AZLI 75 mg three times a day (TID)
- Where
- 53 sites in United States, Australia and 2 more
- Volunteers
- 166 people
- Sponsor
- Gilead Sciences
Cystic Fibrosis
Study of Individualized Physiotherapy for Airway Clearance in Cystic Fibrosis.
The purpose of this study is to investigate individual efficacy in Physiotherapy for Airway Clearance, and to investigate user experience, i.e.utility value and preference.
- Trial name
- NCT01266473
- Testing
- Physiotherapy
- Volunteers
- 6 people
- Sponsor
- Oslo University Hospital
Cystic Fibrosis
The EPIC Observational Study
The purpose of this study is to better define risk factors preceding first isolation of Pseudomonas aeruginosa (Pa) from respiratory cultures in cystic fibrosis (CF) lung disease and to better define clinical outcomes associated…
- Trial name
- EPIC OBS (NCT00676169)
- Where
- 54 sites in United States
- Volunteers
- 1,248 people
- Sponsor
- CF Therapeutics Development Network Coordinating Center
Cystic Fibrosis, Lung Infection Bacterial
Clinical Performance of the AtbFinder® Test System for Selection of Antibiotic Therapy in Persons With Cystic Fibrosis
This prospective case-control study was planned to evaluate the efficacy of antibiotic therapy selected with the AtbFinder® in persons with cystic fibrosis.
- Trial name
- NCT05584982
- Testing
- AtbFinder
- Volunteers
- 35 people
- Sponsor
- TGV-Dx
COVID-19, Cystic Fibrosis
COVID-19 Antibody Responses In Cystic Fibrosis
Coronavirus disease 2019 (COVID-19) which is caused by the virus SARS-CoV-2 has resulted in an ongoing global pandemic. It is unclear whether the relatively low number of reported cases of COVID-19 in people with CF (pwCF) is due…
- Trial name
- CAR-CF (NCT06274840)
- Where
- Portugal
- Volunteers
- 1,000 people
- Sponsor
- Pilar Azevedo
Cystic Fibrosis
Biomarkers of Iron Homeostasis and Responses to Cystic Fibrosis Pulmonary Exacerbation (CFPE) Treatment
The goal of this study is to identify chemical compounds in the blood and sputum (i.e., biomarkers) that are associated with objective measurements of health status in patients with cystic fibrosis (CF).
- Trial name
- NCT02188758
- Testing
- Adults - CFPE Treatment
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cystic Fibrosis
Assessing Mucociliary Clearance and Airway Liquid Volume in the CF Airway
The objective of this study is to determine the effect of airway surface liquid (ASL) volume on mucociliary clearance in cystic fibrosis (CF). A two-isotope nuclear medicine technique will be utilized.
- Trial name
- NCT00248755
- Testing
- mucociliary clearance scan
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cystic Fibrosis
Phase 1, QT/QTC Interval Study in Healthy Subjects
This study is designed to evaluate the effect of multiple doses of lumacaftor in combination with ivacaftor on cardiac repolarization, as detected by QT/QTc interval corrected for heart rate in healthy subjects.
- Trial name
- NCT01910415
- Testing
- Lumacaftor, Ivacaftor, moxifloxacin hydrochloride
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis Related Diabetes, Cystic Fibrosis
The Use of Home Oral Glucose Tolerance Test Kit in Screening Cystic Fibrosis Related Diabetes
The aim of this study is to establish if the self-administered electronic Oral Glucose Tolerance Test kit can increase the annual uptake of screening for CFRD in children who are between 10 and 17 years of age with CF.
- Trial name
- HomeOGTT (NCT02703155)
- Testing
- Home Oral Glucose Tolerance Test kit
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Cystic Fibrosis
An Electrocardiogram Study to Evaluate the Effect of Vanzacaftor on the QT/QTc Interval in Healthy Participants
The purpose of this study is to evaluate the effect of Vanzacaftor (VNZ) on QTcF, as well as the pharmacokinetic (PK), safety, and tolerability of VNZ in healthy participants.
- Trial name
- NCT05867147
- Testing
- Vanzacaftor, Moxifloxacin
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis, Chronic Obstructive Pulmonary Disease (COPD)
Prevalence and Treatment of Urinary Incontinence in Women With Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
Women with chronic lung disease characterised by chronic cough report urinary incontinence. Recently there have been reports of increased urinary incontinence in girls and women with cystic fibrosis.
- Trial name
- NCT00164138
- Testing
- Pelvic floor training group
- Where
- 2 sites in Australia
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Cystic Fibrosis
Glycemic Monitoring in Cystic Fibrosis
Current guidelines on the diagnoses and management of cystic fibrosis (CF) related diabetes recommend treatment for diabetes based on diagnostic criteria derived from adults with type 2 diabetes.
- Trial name
- GEM (NCT02211235)
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis
Study of GLPG1837 in Subjects With Cystic Fibrosis (G551D Mutation)
32 cystic fibrosis patients with the G551D mutation will be treated for 4 weeks, consisting of three consecutive treatment periods: two 1-week periods followed by one 2-week period, evaluating one dose of GLPG1837 each.
- Trial name
- SAPHIRA1 (NCT02707562)
- Testing
- GLPG1837 dose 1, GLPG1837 dose 2, GLPG1837 dose 3
- Where
- 16 sites in Australia, Czechia and 3 more
- Volunteers
- 26 people
- Sponsor
- Lakefront Biotherapeutics NV
Cystic Fibrosis
Prospective Intervention Study on Vitamin D in Patients With Cystic Fibrosis
The vast majority of Cystic Fibrosis (CF) patients worldwide are vitamin D insufficient. There is no evidence of benefit of vitamin D supplementation for CF patients yet.
- Trial name
- D-vitamin (NCT01321905)
- Testing
- Supplementation with vitamin D2/D3
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Karolinska Institutet
Cystic Fibrosis
Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF)
Zinc deficiency has occasionally been reported in CF, but the need for additional zinc is unclear. We will examine the effect of additional zinc supplements on zinc absorption, zinc excretion, zinc balance and zinc kinetics in…
- Trial name
- NCT00104494
- Testing
- Zinc acetate (20mg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cystic Fibrosis Foundation
Cystic Fibrosis, Parenthood Status
Health Outcomes of Parents With Cystic Fibrosis-Aim 2
The goal of this observational prospective study is to determine the health impact of parenthood on United States (US) people with CF in the era of CF transmembrane regulator protein (CFTR) modulators.
- Trial name
- HOPeCF (NCT06296394)
- Testing
- Parenthood
- Where
- 18 sites in United States
- Volunteers
- 146 people
- Sponsor
- University of Pittsburgh
Cystic Fibrosis
Ready to Use Therapeutic Food (RUTF) to Promote Growth in Cystic Fibrosis
Children with cystic fibrosis require increased caloric intake to maintain appropriate growth, an important determinant of long-term outcomes.
- Trial name
- NCT03462056
- Testing
- Cystic Fibrosis Ready to Use Supplemental Food
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Cystic Fibrosis (CF)
Autogenic Drainage Versus Mechanical Percussion in Children With Cystic Fibrosis
The goal of this clinical trial is to compare the effects of autogenic drainage and mechanical percussion on lung function, dyspnea, and quality of life in children with cystic fibrosis.
- Trial name
- ADMP-CF (NCT07729787)
- Testing
- Autogenic Drainage, Mechanical Percussion
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University