Clinical trials: Pancreatic Necrosis
Necrotizing Pancreatitis
Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis
Necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis).
- Trial name
- NCT01815489
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pancreas Necrosis, Pancreatic Collection
EUS-guided Transmural Drainage of Walled-off Pancreatic Necrosis: Plastic vs Metallic Protesis.
Randomized multicenter study comparing plastic stents and self-expanding metallic stents in the eus-guided transmural drainage of walled-off pancreatic necrosis.
- Trial name
- PROMETHEUS (NCT03100578)
- Testing
- WOPN TRANSMURAL DRAINAGE: PLASTIC STENT, WOPN TRANSMURAL DRAINAGE: METALLIC STENT
- Where
- 8 sites in Spain
- Volunteers
- 99 people
- Sponsor
- Hospital Universitari de Bellvitge
Gastric Outlet Obstruction, Biliary Obstruction
Prospective Registry Of Therapeutic EndoscopiC ulTrasound
This registry aims to analyze long-term outcomes of therapeutic EUS (T-EUS) procedures, as well as to describe clinical and technical variables potentially predicting clinical success or adverse events, for a better selection of…
- Conditions
- Gastric Outlet Obstruction, Biliary Obstruction, Acute Pancreatic Fluid Collection, Acute Pancreatitis With Infected Necrosis
- Trial name
- PROTECT (NCT04813055)
- Testing
- Therapeutic EUS, Percutaneous Procedures, Surgical Interventions
- Where
- Italy
- Volunteers
- 510 people
- Sponsor
- Paolo Giorgio Arcidiacono, MD
Pancreatitis, Walled Off Pancreatic Necrosis
Bedside Monitoring of Microenvironmental Changes in Infected Pancreatic Collections
This pilot clinical study aims to assess the feasibility and clinical relevance of bedside monitoring of microenvironmental conditions within infected walled-off pancreatic necrosis (WOPN).
- Trial name
- WOPN-MONITOR (NCT07131917)
- Testing
- Miniaturized Intracavitary Monitoring Probe
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Martin Harazim
Pancreatitis
Management of Pancreatitis: the Role of Supportive and Drainage Treatment
This study aims to investigate the natural clinical course, diagnostic possibilities and treatment modalities in moderately severe (MSAP) and severe acute pancreatitis (SAP).
- Trial name
- NCT02648815
- Testing
- Percutaneous catheter drainage, Abdominal paracentesis evacuation
- Volunteers
- 100 people
- Sponsor
- University Clinical Center Tuzla
Tumors
One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy
This study will include a one time intravenous (IV) infusion of Clostridium novyi-NT (C. novyi-NT) spores to treat solid tumors which have not responded to standard therapy.
- Trial name
- NCT00358397
- Testing
- Clostridium novyi-NT spores
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acute Necrotizing Pancreatitis
Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis
Acute necrotizing pancreatitis is a frequent and potentially lethal disease, especially in case of infected pancreatic necrosis (IPN). IPN usually occurs after the first week of evolution.
- Trial name
- PANIC (NCT03234166)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Acute Necrotizing Pancreatitis
Significance of Collections Around Colon in Patients With Acute Necrotizing Pancreatitis
Acute pancreatitis is an inflammatory process which causes a local and systemic inflammatory response syndrome (SIRS). Although the majority of patients have a mild disease course, around 20% will develop moderate or severe…
- Trial name
- NCT03411629
- Where
- India
- Volunteers
- 44 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Pancreatic Necrosis, Pancreatitis
Surgical vs Endoscopic Resection of Walled Off Pancreatic Necrosis Using the Powered Endoscopic Debridement System
Goal: The goal of this clinical trial is to compare the effectiveness and safety of two different but highly effective treatment approaches for walled-off necrosis (WON) resulting from severe acute pancreatitis.
- Trial name
- SERPENT (NCT06691919)
- Testing
- Direct Endoscopic Necrosectomy with Powered Endoscopic Debridement, Transgastric Surgical Necrosectomy
- Sponsor
- Stanford University
Acute Pancreatitis, Necrotizing Pancreatitis
Timing of Transmural Stent Removal in Necrotizing Pancreatitis
Although metal stents have been widely used in the endoscopic step-up approach for necrotizing pancreatitis, the exact timing of transmural stent removal has not been well studied.
- Conditions
- Acute Pancreatitis, Necrotizing Pancreatitis, Walled-Off Necrosis
- Trial name
- TTSRNP (NCT04963868)
- Testing
- Stent removed by the novel strategy, Stent removed by the conventional strategy
- Where
- China
- Volunteers
- 156 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Pancreatic Walled-off Necrosis
The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON)
In this multicenter, randomized controlled trial, patients with pancreatic walled-off necrosis (WON) based on inclusion and exclusion criteria will be randomly assigned in a 1:1 ratio to either receive intravenous infusion or…
- Trial name
- NCT07488299
- Testing
- Proton Pump Inhibitors
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
Necrosis of Pancreas, Infected Pancreatic Necrosis
Minimally Invasive Surgery vs. Endoscopy Randomized (MISER) Trial for Necrotizing Pancreatitis
Prospective, randomized controlled trial comparing Endoscopic Ultrasound (EUS) Guided cystogastrostomy or cystoduodenostomy and endoscopic necrosectomy to minimally invasive surgical necrosectomy, in patients with necrotizing…
- Trial name
- MISER (NCT02084537)
- Testing
- Endoscopic treatment, Minimally invasive surgical necrosectomy
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- AdventHealth
Acute Necrotizing Pancreatitis, Walled Off Necrosis
Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis
Introduction: Walled off necrosis (WON) is defined as a well circumscribed pancreatic and/or peri pancreatic necrosis containing a variable amount of necrotic tissue.
- Trial name
- NCT04479228
- Testing
- Endosonography guided transmural drainage
- Volunteers
- 80 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Necrotizing Pancreatitis
Early Enteral Nutrition for Severe Acute Pancreatitis
There is increasing evidence that indicates early enteral nutrition may be associated with improved outcome in acute pancreatitis patients.
- Trial name
- NCT00995098
- Testing
- early enteral nutrition, Parenteral nutrition
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sichuan Academy of Medical Sciences
Pancreatitis, Acute Necrotizing
Immediate vs. On-demand Endoscopic Necrosectomy in Infected Walled-off Pancreatic Necrosis
Acute pancreatitis is one of the most common diagnoses made in gastroenterology wards worldwide which causes a great deal of pain and expense along with fatal complications.
- Trial name
- NCT05530772
- Testing
- Endoscopic necrosectomy
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- University of Tehran
Necrotizing Pancreatitis
Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open Necrosectomy
The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.
- Trial name
- NCT06380842
- Testing
- Necrotizing Pancreatitis patients' organ dysfunction progression
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chunling Jiang
Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP)
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis
The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis.
- Conditions
- Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP), Endoscopic Ultrasound-Guided Drainage
- Trial name
- NCT07395778
- Testing
- endoscopic ultrasonography guided cystogastrostomy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Necrotizing Pancreatitis
Tracking ENcapsulation of Pancreatic Collections in Acute Necrotizing Pancreatitis
The goal of this study is to investigate the encapsulation of fluid collections in patients with ANP using serial MRI. The main questions it aims to answer are: Evaluating the timing of encapsulation of necrotic fluid collection…
- Trial name
- NCT05716633
- Testing
- MRI
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pancreatic Necrosis
Predicting Pancreatic Necrosis Using mitDNA
Multiple predictors have been used for early pancreatic necrosis, prediction, detection, and monitoring. These include clinical score systems and circulating biomarkers.
- Trial name
- NCT03788928
- Testing
- serum mitochondrial DNA
- Volunteers
- 25 people
- Sponsor
- Assiut University
Acute Pancreatitis, Acute Pancreatic Necrosis
coMpliAnce With evideNce-based cliniCal Guidelines in the managemenT of Acute biliaRy pancreAtitis
Acute pancreatitis (AP) is an inflammatory disease of the pancreas, most commonly caused by gallstones, or excessive use of alcohol. It represents a management challenge and a significant healthcare burden.
- Conditions
- Acute Pancreatitis, Acute Pancreatic Necrosis, Acute Pancreatitis Due to Gallstones, Acute Pancreatic Fluid Collection
- Trial name
- MANCTRA-1 (NCT04747990)
- Testing
- Early Definitive Treatment
- Where
- 3 sites in Italy, Spain
- Volunteers
- 600 people
- Sponsor
- University of Cagliari