Clinical trials: Pancreatic Necrosis, active
Acute Pancreatitis (AP)
Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis
The planned multicenter randomized study is aimed to assess the efficacy and safety of endoscopic pancreatic duct stenting in adult patients with acute pancreatitis.
- Trial name
- NCT07093996
- Testing
- Endoscopic pancreatic duct stent placement, Conventional treatment of acute pancreatitis in early phase
- Where
- 7 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Almazov National Medical Research Centre
Acute Necrotizing Pancreatitis, Infected Pancreatic Necrosis
Integrating Plasma Metagenomics and Host Response for Accurate Diagnosis of Infected Pancreatic Necrosis in a Prospective Multicenter Cohort of Acute Necrotizing Pancreatitis
This study is being done to find a faster and more accurate way to tell whether the necrosis in patients with acute necrotizing pancreatitis (ANP) has become infected.
- Trial name
- PROMOTE (NCT07308600)
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Acute Pancreatitis (AP), Acute Pancreatitis With Infected Necrosis
Comparison of MIPPED-C and Surgical Necrosectomy in Pancreatic Necrosis Outcomes
This study is a retrospective, single-center, pre-post controlled clinical study. Patients (n=48) who underwent the MIPPED-C surgical procedure after January 1, 2019 were designated as the treatment group.
- Trial name
- NCT07097753
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Ruijin Hospital
Acute Necrotizing Pancreatitis
Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility Analysis
This is a national single-blinded prospective multicenter randomized (1:1) controlled trial, with two parallel arms, using a PROBE methodology, including patients with complicated acute necrotizing pancreatitis who require DEN of…
- Trial name
- ROTONEC (NCT07253350)
- Testing
- Endorotor Group, Conventional group
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis
DEciphering CIrculating SIgnatures Of Infected Pancreatic Necrosis
The purpose of the study is to identify novel blood-based biomarkers for prediction and diagnosis of infected pancreatic necrosis (IPN) in patients with necrotizing pancreatitis (NP).
- Trial name
- NCT06899087
- Testing
- not interventional
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Gastric Outlet Obstruction, Biliary Obstruction
Prospective Registry Of Therapeutic EndoscopiC ulTrasound
This registry aims to analyze long-term outcomes of therapeutic EUS (T-EUS) procedures, as well as to describe clinical and technical variables potentially predicting clinical success or adverse events, for a better selection of…
- Conditions
- Gastric Outlet Obstruction, Biliary Obstruction, Acute Pancreatic Fluid Collection, Acute Pancreatitis With Infected Necrosis
- Trial name
- PROTECT (NCT04813055)
- Testing
- Therapeutic EUS, Percutaneous Procedures, Surgical Interventions
- Where
- Italy
- Volunteers
- 510 people
- Sponsor
- Paolo Giorgio Arcidiacono, MD
Acute Necrotizing Pancreatitis, Pancreatic Exocrine Insufficiency
Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis
In this multicenter, double blinded, placebo-controlled, 1:1 parallel group RCT, the investigators propose to evaluate the impact of pancreatic exocrine replacement therapy on patients with acute necrotizing pancreatitis (ANP).
- Trial name
- PERiANP (NCT07441824)
- Testing
- Pancreatic enzyme capsules
- Where
- 4 sites in India
- Volunteers
- 140 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Pancreatitis, Pancreatic Pseudocyst
Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant…
- Conditions
- Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06179459
- Testing
- Endoscopic management of pancreatic fluid collections
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Orlando Health, Inc.
Walled Off Necrosis, Pancreatitis
Encapsulation-oriented vs. Timing-oriented Strategies for Necrotizing Pancreatitis
This multicenter, randomized controlled trial (WONDER-03 study) investigates the optimal timing for endoscopic ultrasound (EUS)-guided drainage in patients with necrotizing pancreatitis.
- Conditions
- Walled Off Necrosis, Pancreatitis, Acute Necrotic Collection, Necrotizing Pancreatitis
- Trial name
- WONDER-03 (NCT07106346)
- Testing
- The timing of endoscopic intervention for necrotizing pancreatitis is determined based on the degree of encapsulation, EUS-guided drainage based on the interval from the onset of acute pancreatitis
- Where
- 36 sites in Japan
- Volunteers
- 224 people
- Sponsor
- Tokyo University
Acute Necrotizing Pancreatitis, Portal Hypertension
A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension
This study is a prospective, single-center, randomized controlled trial focusing on patients with acute necrotizing pancreatitis (ANP) complicated by pancreatic sinistral portal hypertension (PSPH).
- Trial name
- NCT07080697
- Testing
- Splenectomy, Control
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhejiang University
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Acute Pancreatitis, Necrosis; Pancreas, Acute (Infectious)
Conventional Endoscopic Techniques Versus EndoRotor® System for Necrosectomy of Walled of Necrosis
In acute pancreatitis, approximately 20% of the cases result in severe necrotizing pancreatitis which is associated with significant morbidity and mortality.
- Trial name
- RESOlVE (NCT04814693)
- Testing
- EndoRotor® System (Interscope, Inc., Northbridge, MA USA),, Conventional endoscopic devices (according to standards of care)
- Where
- 12 sites in United States, Denmark and 4 more
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center
Necrotizing Pancreatitis
Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy
The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.
- Trial name
- NCT07201246
- Testing
- Necrotizing Pancreatitis patients' organdysfunction progression
- Where
- China
- Volunteers
- 700 people
- Sponsor
- West China Hospital
Necrotizing Pancreatitis
Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open Necrosectomy
The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.
- Trial name
- NCT06380842
- Testing
- Necrotizing Pancreatitis patients' organ dysfunction progression
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chunling Jiang
Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP)
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis
The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis.
- Conditions
- Walled Off Pancreatic Necrosis, Acute Pancreatitis (AP), Endoscopic Ultrasound-Guided Drainage
- Trial name
- NCT07395778
- Testing
- endoscopic ultrasonography guided cystogastrostomy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Pancreatitis Necrotizing, Nutrition Assessment
PERT in Acute Necrotizing Pancreatitis
In this multicenter, double blinded, placebo-controlled, 1:1 parallel group RCT, we propose to evaluate the impact of pancreatic exocrine replacement therapy on patients with acute necrotizing pancreatitis (ANP).
- Trial name
- PERT-ANP (NCT07211568)
- Testing
- Pancreatic Enzyme Replacement Therapy
- Volunteers
- 188 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Pancreatitis, Acute Pancreatitis With Infected Necrosis
Pancreatitis - Microbiome as Predictor of Severity II
The goal of this observational study is to evaluate the orointestinal microbiome and microbial derived metabolome in patients suffering from acute pancreatitis as a biomarker for severity.
- Trial name
- P-MAPS II (NCT06508502)
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- University Medical Center Goettingen
Pancreatic Walled-off Necrosis
The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON)
In this multicenter, randomized controlled trial, patients with pancreatic walled-off necrosis (WON) based on inclusion and exclusion criteria will be randomly assigned in a 1:1 ratio to either receive intravenous infusion or…
- Trial name
- NCT07488299
- Testing
- Proton Pump Inhibitors
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University