Clinical trials: Pancreatitis
Pancreatic Cancer, Pancreatitis
TOF-18F-FDG-PET/CT in Patients With Suspected Pancreatic Cancer
Aim of the prospective study is a better differentiation of benign and malignant lesions in the pancreas in patients with suspected pancreatic cancer using images 30 and 90 min p.i.
- Conditions
- Pancreatic Cancer, Pancreatitis, IPMN
- Trial name
- TOF-P (NCT03914950)
- Testing
- PET/CT results with TOF/without TOF
- Volunteers
- 174 people
- Sponsor
- Medical University of Graz
Acute Pancreatitis
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis
This is a randomized, double-blind, placebo-controlled pilot trial seeking to evaluate the efficacy of rectal indomethacin in abrogating systemic inflammation and subsequently organ failure and mortality in patients with AP and…
- Trial name
- NCT02692391
- Testing
- Indomethacin
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Pittsburgh
Pancreas Tumor, Pancreatitis
Pancreas Resection With and Without Drains
This randomized prospective trial is designed to test the hypothesis that pancreatectomy without routine intraperitoneal drainage does not increase the severity or frequency of complications within 60 days of surgery.
- Trial name
- NCT01441492
- Testing
- No Drains, Drains
- Where
- 14 sites in United States, Canada
- Volunteers
- 399 people
- Sponsor
- Baylor College of Medicine
Feeding Tube
Self-Propelled Versus Standard Percutaneous Endoscopic Gastrojejunostomy(PEG-J); RCT
Our main hypothesis is that self-propelled Percutaneous Endoscopic Gastrojejunostomy tube (PEG-J) that has a balloon on it's tip is associated with lower J-tube retrograde migration rate, and lower rates of short- and long-term…
- Trial name
- NCT01892267
- Testing
- PEG-J placement
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Acute Pancreatitis
Use of Patient-Controlled Analgesia in Acute Pancreatitis
Acute pancreatitis (AP) represents a critical health concern nationwide, with estimated 274,000 admissions annually and at a cost of 2.6 billion dollars.
- Trial name
- PCA-AP (NCT04816877)
- Testing
- Opioid
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Pancreatitis
Trial of Indomethacin in Chronic Pancreatitis
The researchers are trying to find a way to slow down the progression of chronic pancreatitis (CP) and investigate the possibility of the long term treatment of this disease.
- Trial name
- NCT04207060
- Testing
- Indomethacin, Endoscopy for Pancreatic Function Testing
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Healthy Volunteers
MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics
The goal of this research study is to learn more about the pancreas. The investigators want to use Magnetic Resonance Cholangiopancreatography (MRCP) to learn more about the size of a normal pancreas.
- Trial name
- NCT02869893
- Testing
- Secretin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Pancreatitis, Insulin Resistance
Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality
The purpose of this study is to determine if study drug (Pioglitazone) treatment will improve pre-diabetes (insulin resistance) or ealy diabetes and improve clinical symptoms (pain) or laboratory evidence of chronic pancreatitis.
- Conditions
- Chronic Pancreatitis, Insulin Resistance, Normal or Mildly Abnormal Stool Fat Levels
- Trial name
- NCT00782795
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Severe Hypertriglyceridemia
An Open-Label Crossover Study to Compare the Relative Bioavailability, Efficacy and Safety of Epanova® and Lovaza® in Men and Women With a History of Pancreatitis
This is a randomized, open-label crossover study. The primary objective of this study is to compare the relative bioavailability of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and the…
- Trial name
- ECLIPSEIV (NCT02189252)
- Testing
- Epanova, Lovaza
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Post-ERCP Acute Pancreatitis
Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
This research is being done to see if using a combination of rectal indomethacin and epinephrine spray during endoscopy, can prevent pancreatitis that may occur after ERCP (a type of gastrointestinal endoscopy).
- Trial name
- INDIEH (NCT02116309)
- Testing
- Rectal Indomethacin, Epinephrine
- Where
- 4 sites in United States, India
- Volunteers
- 948 people
- Sponsor
- Johns Hopkins University
Pancreatitis
Rectal Indomethacin to Prevent Post ESWL-pancreatitis
The purpose of the study is to determine whether rectal indomethacin reduces the incidence of post-ESWL pancreatitis.
- Trial name
- RIPEP (NCT02797067)
- Testing
- indomethacin suppository, Glycerin Suppository
- Where
- China
- Volunteers
- 1,370 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Role of Home-based Transcutaneous Electrical Acustimulation for Treatment of Pain in Patients With Chronic Pancreatitis
This research is studying a new noninvasive device-based therapy called Transcutaneous Electrical Acustimulation (TEA) to learn about its safety and how well it works as a treatment of pain in chronic pancreatitis.
- Trial name
- NCT06015945
- Testing
- Transcutaneous Electrical Acustimulation (TEA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Hypertriglyceridemia
Efficacy and Safety of Evinacumab in Adult Patients With Severe Hypertriglyceridemia for the Prevention of Recurrent Acute Pancreatitis
The primary objective of the study is to determine the proportion of patients with elevated triglycerides (TG), without familial chylomicronemia syndrome (FCS) due to loss of function (LoF) mutations in lipoprotein lipase (LPL)…
- Trial name
- NCT04863014
- Testing
- evinacumab
- Where
- 39 sites in United States, Canada and 2 more
- Volunteers
- 21 people
- Sponsor
- Regeneron Pharmaceuticals
Diabetes Mellitus, Type 1
The Effect of Pancreatic Polypeptide on Insulin Requirements for Type 1 & Post-pancreatectomy Diabetic Patients
The goal of this research is to see if pancreatic polypeptide (PP), a hormone that is naturally produced by the pancreas and that works to control the amount of glucose that the liver makes, will reduce the amount of insulin…
- Trial name
- NCT00791076
- Testing
- Pancreatic Polypeptide (PP)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Johns Hopkins University
Pancreatitis, Pancreas Divisum
SpHincterotomy for Acute Recurrent Pancreatitis
The purpose of this study is to determine if a procedure called Endoscopic Retrograde CholangioPancreatography (ERCP) with sphincterotomy reduces the risk of pancreatitis or the number of recurrent pancreatitis episodes in…
- Conditions
- Pancreatitis, Pancreas Divisum, Pancreatitis, Acute, Pancreatitis Idiopathic
- Trial name
- SHARP (NCT03609944)
- Testing
- ERCP with miES, EUS
- Where
- 21 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- Oregon Health and Science University
Sphincter of Oddi Dysfunction
Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction
The Evaluating Predictors \& Interventions in Sphincter of Oddi Dysfunction(SOD) study (EPISOD) is a randomized sham-controlled study of biliary and pancreatic sphincterotomy as treatment for patients with pain after…
- Trial name
- EPISOD (NCT00688662)
- Testing
- ERCP with sphincterotomy, ERCP without sphincterotomy
- Where
- 7 sites in United States
- Volunteers
- 214 people
- Sponsor
- Medical University of South Carolina
Post-ERCP Pancreatitis
Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis
Background: Pancreatitis is the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP), accounting for substantial morbidity, occasional mortality, and increased health care expenditures.
- Trial name
- SVI (NCT02476279)
- Testing
- Indomethacin 100 mg rectally immediately after ERCP, NO prophylactic pancreatic stent placement, Indomethacin 100 mg rectally immediately after ERCP AND prophylactic pancreatic stent placement
- Where
- 20 sites in United States, Canada
- Volunteers
- 1,950 people
- Sponsor
- Medical University of South Carolina
Post-ERCP Acute Pancreatitis
Rectal Indomethacin vs Intravenous Ketorolac
Endoscopic retrograde cholangiopancreatography (ERCP) is an essential procedure that can be complicated by post-ERCP pancreatitis (PEP). Indomethacin and ketorolac are two medications used to prevent PEP.
- Trial name
- NCT05664074
- Testing
- Rectal indomethacin, IV ketorolac
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- David Vitale MD
Chronic Pancreatitis
WallFlex Pancreatic Metal Stent for Pancreatic Duct Strictures
To prospectively document the performance of a FCSEMS for treatment of pancreatic duct strictures in patients with painful chronic pancreatitis.
- Trial name
- NCT02802020
- Testing
- Pancreatic fully-covered self-expanding metal stent (FCSEMS)
- Where
- 11 sites in United States, Belgium and 4 more
- Volunteers
- 67 people
- Sponsor
- Boston Scientific Corporation
Acute Pancreatitis
Magnetic Resonance Imaging Study of Acute Pancreatitis
To quantitatively analyze the T2* values of the head, body, and tail of normal pancreas, and observe the value of GRE T2*-weighted MRI in the diagnosis of acute pancreatitis and the relationship between the T2* value and the…
- Trial name
- NCT01911689
- Where
- China
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of North Sichuan Medical College