Clinical trials: Pancreatitis
Pancreatitis
EUROPAC-2 - Pain Treatment of Hereditary and Idiopathic Pancreatitis
This is a multi-centre randomised phase III, double blind, placebo controlled, parallel group, outpatient study in patients diagnosed with hereditary pancreatitis and idiopathic chronic pancreatitis.
- Trial name
- NCT00142233
- Testing
- ANTOX (vers.)1.2, Magnesium
- Volunteers
- 295 people
- Sponsor
- University Medicine Greifswald
Exocrine Pancreatic Insufficiency
An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)
EPI leading to maldigestion is a frequent finding in many diseases of the pancreas, such as chronic pancreatitis (CP). Steatorrhea is the most important digestive manifestation in EPI.
- Trial name
- NCT00559052
- Testing
- VIOKASE 16
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Axcan Pharma
Pancreatic Necrosis, Pancreatitis, Acute Necrotizing
Endoscopic Step-up Approach vs Aggressive Debridement of Large Pancreatic Walled-off Necrosis
The goal of this clinical trial is to compare a conventional endoscopic step-up approach with an accelerated treatment algorithm using direct endoscopic necrosectomy in patients with acute necrotizing pancreatitis and walled of…
- Trial name
- NCT05601687
- Testing
- Direct Endoscopic Necrosectomy, Step-up Approach
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Severe Acute Pancreatitis
High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis
This study is a prospective, randomized, double-blinded, parallel-controlled, multi-central clinical trial for patients with severe acute pancreatitis (SAP).
- Trial name
- NCT06897384
- Testing
- Saline (NaCl 0,9 %), Vitamin C (Ascorbic Acid)
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Ruijin Hospital
Chronic Pancreatitis
A Prospective Study of Natural History of Pancreatitis
To prospectively define the natural history and the clinical, laboratory and histomorphometric features of chronic pancreatitis (CP) of varying etiology.
- Trial name
- NCT00685087
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Virginia Commonwealth University
Pancreatic Cancer, Pancreas Cancer
Role of Proton Pump Inhibitors on the Postoperative Course Following Pancreaticoduodenectomy
The purpose of this study is to prospectively determine the effects of administering proton pump inhibitors (PPIs) following pancreaticoduodenectomy on postoperative outcomes.
- Conditions
- Pancreatic Cancer, Pancreas Cancer, Ampullary Cancer, Pancreas Neuroendocrine Tumor
- Trial name
- NCT05251233
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Pancreatic Neoplasms, Pancreatic Cancer
Project Survival-Prospective Biomarker Discovery
This sample-collection study is open to participants in several categories: healthy volunteers (with or without a family history of pancreatic cancer) and individuals diagnosed with pancreatitis or any stage of pancreatic cancer.
- Conditions
- Pancreatic Neoplasms, Pancreatic Cancer, Pancreatitis, Pancreatic Adenocarcinoma
- Trial name
- NCT02781012
- Where
- 6 sites in United States
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- Pancreatic Cancer Research Team
Pancreatitis, Chronic, Pancreatitis
Celiac Plexus Block for Chronic Pancreatitis RCT
Rationale: Chronic pancreatitis is a chronic inflammatory disease of the pancreas which results in debilitating abdominal pain, decreased productivity and increased health care costs.
- Trial name
- NCT02399800
- Testing
- Celiac Block with triamcinolone and bupivicaine, No Celiac Block, Intra Plexus Triamcinolone and Bupivicaine Injection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Southern California
Pancreatitis, Acute, ERCP
Post-ERCP Pancreatitis - Prophylactic Measures Implementation Study (PEP-PROMIS)
This is a prospective, observational (non-interventional), multicenter study that will look at how often inflammation of the pancreas (called post-ERCP pancreatitis, or PEP) occurs after an endoscopic procedure known as ERCP.
- Conditions
- Pancreatitis, Acute, ERCP, Prophylaxis
- Trial name
- PEP-PROMIS (NCT07244432)
- Where
- 13 sites in Czechia, Slovakia
- Volunteers
- 1,135 people
- Sponsor
- Branislav Kuncak
Pancreatitis
ESWL Versus ESWL and Endoscopic Treatment
The study wants to compare ESWL alone with ESWL and endoscopic drainage of the MPD for treatment of pain in chronic pancreatitis.
- Trial name
- NCT02971475
- Testing
- extracorporeal shock wave lithotripsy, endoscopic drainage of the main pancreatic duct, Analgesics
- Where
- 2 sites in China
- Volunteers
- 62 people
- Sponsor
- Changhai Hospital
Ampulla of Vater Neoplasms, Ampullary Adenoma
Effect of Negative-Pressure Drainage Versus Pancreatic Duct Stenting for Preventing Pancreatitis After Endoscopic Papillectomy for Duodenal Papillary Tumors
This prospective, multicenter, randomized controlled trial aims to evaluate the effectiveness of negative-pressure duodenal drainage compared with prophylactic pancreatic duct stenting in preventing post-endoscopic papillectomy…
- Conditions
- Ampulla of Vater Neoplasms, Ampullary Adenoma, Ampullary Carcinoma
- Trial name
- NCT07446543
- Testing
- Placement of a negative pressure drainage tube, Placement of a pancreatic duct stent
- Volunteers
- 132 people
- Sponsor
- Cui Xiaobing
Painless Chronic Pancreatitis
Endotherapy and/or Extracorporeal Shockwave Lithotripsy for Painless Chronic Pancreatitis
Chronic pancreatitis (CP) is caused by factors such as genetics and the environment, leading to the destruction of pancreatic tissue, infiltration of inflammatory cells, and progressive fibrosis of the pancreas.
- Trial name
- PCP (NCT07074379)
- Testing
- Lifestyle modifications, Pancreatic enzyme replacement therapy (PERT) and glycemic control therapy, Endoscopic Retrograde Cholangiopancreatography (ERCP) and/or Extracorporeal Shockwave Lithotripsy (ESWL)
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Changhai Hospital
Abdominal Pain, Acute Pain
Diagnostic Performance of Low-Dose CT for Acute Abdominal Conditions
The goal of this non-inferiority observational study is to assess the diagnostic performance of low-dose CT with deep learning image reconstruction (DLIR) in adult participants with acute abdominal conditions.
- Conditions
- Abdominal Pain, Acute Pain, Acute Cholecystitis, Acute Appendicitis
- Trial name
- DETECT_Acute (NCT05651360)
- Testing
- low-dose CT
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 246 people
- Sponsor
- Oslo University Hospital
Pancreatitis, Graft, Pancreatic Transplant Post-Transplant Dysfunction Rejection
18F-Fluciclovine PET/CT in the Assessment of Pancreatic Transplants
Hypothesis 1: 18F-Fluciclovine PET/CT can correctly and easily identify the pancreatic allograft and determine its viability Aim 1: Assess whether 18F-Fluciclovine can identify the pancreatic allograft accurately and assess its…
- Trial name
- NCT04852523
- Testing
- 18F-fluciclovine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Utah
Gastric Outlet Obstruction, Biliary Obstruction
Prospective Registry Of Therapeutic EndoscopiC ulTrasound
This registry aims to analyze long-term outcomes of therapeutic EUS (T-EUS) procedures, as well as to describe clinical and technical variables potentially predicting clinical success or adverse events, for a better selection of…
- Conditions
- Gastric Outlet Obstruction, Biliary Obstruction, Acute Pancreatic Fluid Collection, Acute Pancreatitis With Infected Necrosis
- Trial name
- PROTECT (NCT04813055)
- Testing
- Therapeutic EUS, Percutaneous Procedures, Surgical Interventions
- Where
- Italy
- Volunteers
- 510 people
- Sponsor
- Paolo Giorgio Arcidiacono, MD
Gallstone Pancreatitis
Early Cholecystectomy in Patients With Mild Gallstone Acute Pancreatitis
Randomized controlled trial to demonstrate the safety of early cholecystectomy (<72h) in patients with mild gallstone pancreatitis.
- Trial name
- NCT02590978
- Testing
- Early cholecystectomy, Control (Delayed cholecystectomy)
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Hospital del Salvador
Acute Pancreatitis
Epidural Anesthesia in Acute Pancreatitis
Acute pancreatitis is a common urgency with a mortality rate of up to 30% , decreased blood flow in the pancreatic microcirculation. It seems to be the main cause of the pathophysiology of acute pancreatitis.
- Trial name
- NCT02617199
- Testing
- Epidural anesthesia, intravenous analgesia
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Pancreatitis, Acute Necrotizing
Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis
Infected pancreatic necrosis and its related septic complications are the major cause of death in patients with acute pancreatitis, therefore prevention of pancreatic infection is of great clinical value in the treatment of AP.
- Trial name
- TRACE (NCT02473406)
- Testing
- Thymosin Alpha 1, normal saline
- Where
- 2 sites in China
- Volunteers
- 508 people
- Sponsor
- Weiqin Li
Acute Necrotizing Pancreatitis
Prophylactic Pancreatic Duct Stenting in Acute Necrotizing Pancreatitis
Since the majority of patients with necrotizing pancreatitis will experience a leak from the pancreatic duct during their course of disease resulting in intra- and peripancreatic fluid collections, it is reasonable to hypothesize…
- Trial name
- ERPNEC (NCT01767233)
- Testing
- ERCP and pancreatic stenting
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- University of Oulu