Clinical trials: Papanicolaou Smear
Cervical Cancer Screening, Cervical Cancer Screening Methods
Ameliorated Pap Tests and Cervical Cancer Screening Participation
The Pap test plays a crucial role in the early detection of cervical cancer. A pilot single-center randomized controlled trial applied the peak-end concept and added a non-painful step at the end of Pap smear screening, aimed to…
- Trial name
- NCT06968871
- Testing
- Modified Pap test
- Where
- 5 sites in Taiwan
- Volunteers
- 850 people
- Sponsor
- National Taiwan University Hospital
Cervical Cancer
Use of High-Resolution Microendoscopy (HRME) in Patients With Cervical Dysplasia
The goal of this clinical research study is to compare a type of imaging called high-resolution microendoscopy (HRME) for detecting abnormal tissue in the cervix to the standard of care, which is visual inspection with acetic…
- Trial name
- NCT02420665
- Testing
- Proflavine, HRME Imaging, Phone Call
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer
SmartScope vs Standard Colposcope for the Evaluation of Cervical Dysplasia
This trial will compare images obtained from a mobile colposcope with those obtained using a standard of care.
- Trial name
- NCT02272075
- Testing
- Mobile OCT M3 scope
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Scripps Health
Pain
Ameliorating the Obstacle of Pap Smear
To reduce the procedural pain of Pap smear, this study expects to apply the peak-end rule to Pap smear by prolonging the insertion of speculum after samples are obtained from the cervix.
- Trial name
- NCT04420208
- Testing
- Modified Pap test
- Where
- Taiwan
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Unsatisfactory Pap Smear
Clinical Parameters Predicting Unsatisfactory Cervicovaginal Cytology in Conventional Smears
According the terminology of Bethesda 2001, the unsatisfactory cervical cytology can be categorized into specimen rejected, or specimen processed and examined, but unsatisfactory for evaluation of epithelial abnormality.
- Trial name
- NCT00985309
- Where
- Taiwan
- Sponsor
- Taichung Veterans General Hospital
Intervention Effectiveness
The Effect of Nada Yoga Music and Stress Ball Use on Anxiety and Pain Levels
This parallel-group randomized controlled trial was conducted between Aprıl 2025 and December 2025 at a Training and Research Hospital in Türkiye among women who applied for Pap smear testing.
- Trial name
- NCT07276607
- Testing
- Nada Yoga Music, Stress Ball group:, Nada Yoga Music + Stress Ball group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Agri Ibrahim Cecen University
Breast Cancer, Cervical Cancer
Unidas Por Vida y Salud: Increasing Breast and Cervical Cancer Screening in El Paso
The purpose of this study is to develop, implement and evaluate a comprehensive breast and cervical cancer screening program designed to increase uptake of breast and cervical cancer screening among rarely and never-screened…
- Trial name
- NCT04397744
- Testing
- Unidas por Vida y Salud prevention program
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anxiety, Pain
The Effect Of Virtual Reality Glasses Applied During Pap Smear On Anxiety, Pain And Patient Satisfaction
This research is a randomized controlled experimental study designed to determine the effect of video, which is watched by virtual reality glasses during the procedure, on anxiety, pain and patient satisfaction to women who have…
- Conditions
- Anxiety, Pain, Patient Satisfaction
- Trial name
- NCT05895188
- Testing
- Virtual Reality Glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Cystic Fibrosis
Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis
Background The main risk factor for cervical cancer is the infection by human papillomavirus (HPV), with several intermediate steps between HPV infection and cervical cancer.
- Trial name
- MUCOHPV (NCT03052556)
- Testing
- Pap smear test and HPV test
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Hospices Civils de Lyon
IBD
Anal Dysplasia in Patients With Inflammatory Bowel Disease
The rationale for this study is that the risk of anal dysplasia in patients with inflammatory bowel disease (IBD) as compared to the general population has yet to be investigated prospectively.
- Trial name
- HPVIBD (NCT01653054)
- Testing
- Anal Pap Smear, HPV DNA Testing
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Malignant Tumor of Cervix, Cervical Intraepithelial Neoplasia
Participation in Screening for Cervical Cancer: Interest of a Self-sampling Device Provided by the General Practitioner
This study evaluates the benefit in women aged from 30 to 65 years, who do not participate to the French opportunistic cervical cancer screening program, of an organized screening with the proposition by the family physician of a…
- Trial name
- PaCUDAHL-Gé (NCT02749110)
- Testing
- Vaginal self-sampling brush
- Where
- France
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cervical Cancer, HPV Infection
Identification and Treatment of Cervical Abnormalities in Perú Through Integration of Pocket Colposcopy and Telemedicine
The Pocket colposcope has 510k FDA clearance and has been successfully used in almost 1500 unique patients globally in Duke and non-Duke protocols to date.
- Conditions
- Cervical Cancer, HPV Infection, HIV Infections
- Trial name
- NCT05340322
- Testing
- Colposcopy using pocket colpscope and thermocoagulator
- Where
- Peru
- Volunteers
- 503 people
- Sponsor
- Duke University
Bacterial Vaginosis (BV)
LUXSOL(TM) Topical Cream for the Treatment of Symptomatic Bacterial Vaginosis; A Proof of Concept Study
LUXSOL Cream may be useful for the treatment of bacterial Vaginosis. In this study, LUXSOL Cream is compared to a control arm group using metronidazole cream.
- Trial name
- NCT02197182
- Testing
- LUXSOL copper containing cream, Metronidazole gel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- CDA Research Group, Inc.
Human Papillomavirus Infection
APTIMA HPV 16 18/45 Genotype Assay on the TIGRIS DTS System in Women With ASC-US or Negative Pap Test Results
In both the ASC-US Study and Adjunct Study populations, the objectives are to: evaluate the performance characteristics of the AHPV-GT Assay for detecting cervical disease in women with APTIMA HPV Assay positive results and…
- Trial name
- AHPV-GT (NCT01384370)
- Where
- 3 sites in United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Cervical Cancer
Web-Based Education Program and Educational Booklet Developed on Cervıcal Cancer
Cervical cancer is the fourth most common cancer type among women worldwide and ranks ninth in Turkey, making it the second most common gynecological cancer.
- Trial name
- NCT06705309
- Testing
- Web-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
HPV Infection
Evaluation of the Prevalence of Oral HPV Infection in Patients Who Are Positive to the PAP-test
The present cross-sectional study aims to assess the prevalence and type distribution of oral HPV infection in PAP-test-positive women aged ≥18 years.
- Trial name
- NCT05949398
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Catania
Cancer, Human Papillomavirus
102 Annual Pap Smear Screening Database Maintenance Project
This study aimed to evaluate the subsequent cancer risks, including gynecological cancers and malignancies at other sites, after the detection of screening positives and the diagnosis for primary cervical cancer.
- Trial name
- NCT02063152
- Where
- Taiwan
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Clinical Competence
Augmented Reality Training for Pelvic Exams and Pap Smears in Medical Students
This randomized controlled trial evaluated whether augmented reality (AR)-based pre-simulation training improves the acquisition of speculum examination and Papanicolaou (Pap) smear sampling competencies among undergraduate…
- Trial name
- ARTES (NCT07852078)
- Testing
- Augmented Reality (AR)-Based Training, Conventional Text- and Video-Based Training
- Where
- Chile
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Uterine Cervical Dysplasia, Uterine Cervical Neoplasms
Cervix Cytological Screening - Comparison of Tampon Self-Test and the Routine Smear.
The purpose of this study is to compare suitability, specificity and sensitivity of the routine smear and the tampon self-test women perform at home. Study hypothesis: The tampon self-test correspond to the routine cervical smear.
- Trial name
- NCT00377845
- Testing
- Regular Tampax used in 3 hours
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Human Papilloma Virus, Dysplasia
Phase II Evaluation of AHCC for the Eradication of HPV Infections
This is a phase II randomized, double-blind placebo-controlled, crossover trial. The primary outcome of this trial is achieving durable eradication persistent high risk HPV infection determined by HPV negative test results…
- Conditions
- Human Papilloma Virus, Dysplasia, CIN1, CIN2
- Trial name
- AHCC4HPV (NCT02405533)
- Testing
- AHCC 3 grams once a day
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston