Clinical trials: Papanicolaou Smear
Cystic Fibrosis
Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis
Background The main risk factor for cervical cancer is the infection by human papillomavirus (HPV), with several intermediate steps between HPV infection and cervical cancer.
- Trial name
- MUCOHPV (NCT03052556)
- Testing
- Pap smear test and HPV test
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Hospices Civils de Lyon
Cervical Cancer
A Pap Test Intervention to Enhance Decision Making Among Pacific Islander Women
This community-based randomized trial tested the effects of a social support intervention to increase Chamorro, Samoan, and Tongan women's Pap test behavior and social support among their male spouses or significant others in…
- Trial name
- NCT03064581
- Testing
- Intervention
- Where
- United States
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- California State University, Fullerton
Cervical Cancer, Human Papillomavirus Infection
Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Scientific Context: High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing.
- Trial name
- APACHE-2 (NCT01588301)
- Testing
- Attending for cervical cytology, Kit for Self-collected vaginal sample
- Volunteers
- 5,998 people
- Sponsor
- University Hospital, Tours
Cervical Cancer
Cervical Cancer Detection Using Optical Spectroscopy
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
- Trial name
- NCT00900575
- Testing
- Optical Spectroscopy Bench-Top System, Portable Optical Spectrometer, Transvaginal colposcope
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Duke University
Clinical Competence
Augmented Reality Training for Pelvic Exams and Pap Smears in Medical Students
This randomized controlled trial evaluated whether augmented reality (AR)-based pre-simulation training improves the acquisition of speculum examination and Papanicolaou (Pap) smear sampling competencies among undergraduate…
- Trial name
- ARTES (NCT07852078)
- Testing
- Augmented Reality (AR)-Based Training, Conventional Text- and Video-Based Training
- Where
- Chile
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Papanicolaou Smear
Eisenhower's Alternative Speculum Examination
This study will determine patient and provider preferences regarding vaginal speculum examinations done with and without stirrups.
- Trial name
- EASE (NCT00755599)
- Testing
- no-stirrup vaginal examination, Vaginal speculum examination done with stirrups.
- Where
- United States
- Sponsor
- Eisenhower Army Medical Center
Breast Cancer, Cervical Cancer
Using a Lay Health Worker Program to Increase Breast and Cervical Cancer Screening in Low-Income Hispanic Women
The primary purpose of this study is adapt the Cultivando la Salud (CLS) intervention for a new community and priority population and to train community health workers (promotoras) from the Prosalud promotora program to implement…
- Trial name
- NCT04426019
- Testing
- CLS Intervention, No CLS intervention
- Where
- United States
- Volunteers
- 1,025 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cervical Dysplasia
Oral Diindolylmethane (DIM) for the Treatment of Cervical Dysplasia
To determine if the use of oral Diindolylmethante (DIM), a marketed cruciferous vegetable based dietary supplement (Bioresponse-DIM), is associated with the regression of cervical dysplasia in otherwise healthy women.
- Trial name
- NCT00212381
- Testing
- di indolylmethane (DIM), Red rice bran
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- New York Presbyterian Hospital
Cervical Cancer, HPV Infection
Identification and Treatment of Cervical Abnormalities in Perú Through Integration of Pocket Colposcopy and Telemedicine
The Pocket colposcope has 510k FDA clearance and has been successfully used in almost 1500 unique patients globally in Duke and non-Duke protocols to date.
- Conditions
- Cervical Cancer, HPV Infection, HIV Infections
- Trial name
- NCT05340322
- Testing
- Colposcopy using pocket colpscope and thermocoagulator
- Where
- Peru
- Volunteers
- 503 people
- Sponsor
- Duke University
Uterine Cervical Dysplasia, Uterine Cervical Neoplasms
Cervix Cytological Screening - Comparison of Tampon Self-Test and the Routine Smear.
The purpose of this study is to compare suitability, specificity and sensitivity of the routine smear and the tampon self-test women perform at home. Study hypothesis: The tampon self-test correspond to the routine cervical smear.
- Trial name
- NCT00377845
- Testing
- Regular Tampax used in 3 hours
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
HPV Infection
Evaluation of the Prevalence of Oral HPV Infection in Patients Who Are Positive to the PAP-test
The present cross-sectional study aims to assess the prevalence and type distribution of oral HPV infection in PAP-test-positive women aged ≥18 years.
- Trial name
- NCT05949398
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Catania
Uterine Cervical Neoplasms
Facilitating Follow-Up Adherence for Abnormal Pap Smears
Objective: Previous studies have suggested that psycho-educational interventions delivered by telephone improve adherence to initial colposcopy after an abnormal Pap smear.
- Trial name
- TC3 (NCT01561326)
- Testing
- Cognitive-affective barriers counseling, Cognitive-affective barriers counseling via brochure, standard care
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Fox Chase Cancer Center
Uterine Cervical Neoplasms
Improving Access to Cervical Cancer Screening
Every year, in France, 3 000 women are diagnosed with cervical cancer, and 1 000 die each year. Recent studies highlighted regional, social and economical inequalities with respect to cervical cancer incidence.
- Trial name
- NCT03118258
- Testing
- 'Pap smear' arm, 'Self-collected vaginal swab for HPV testing + pap smear triage' arm
- Where
- France
- Volunteers
- 1,258 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Endometrial Cancer
Detection of Tumor DNA Through Cervical Smear and Liquid Biopsy in Endometrial Cancer Patients and Evaluation of Prognostic and Predictive Values of Tumor DNA Assay
Circulating tumor DNA (ctDNA) may help detect and prognosis-stratify patients with endometrial cancer. Both cervical swab-based genomic DNA (gDNA) and whole blood-based ctDNA can be utilized for this goal.
- Trial name
- NCT05504161
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Healthy Volunteer
Use of Pap Smear Derived Cells to Analyze the Expression of SLC6A14 and GPR81 Genes
SLC6A14 may serve as a biomarker for cervical dysplasia or cervical cancer.
- Trial name
- NCT03039868
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Breast Cancer, Colorectal Cancer
Population-Based Patient-Centric Care: Comprehensive Preventive Cancer Screening Using Health IT
Although there is considerable evidence that current health IT can improve certain elements of care, the most effective and efficient implementation of health IT systems for primary care population management are not currently…
- Conditions
- Breast Cancer, Colorectal Cancer, Cervical Cancer
- Trial name
- TopCare (NCT01372527)
- Testing
- TopCare: Use of provider knowledge vs. automated system
- Where
- United States
- Volunteers
- 103,870 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cervical Cancer, Precancerous Condition
Study of Pap Smears From Patients Enrolled on Clinical Trial GOG-171
RATIONALE: Studying Pap smears in the laboratory from women with atypical glandular cells of unspecified significance may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898144
- Testing
- Papanicolaou test, laboratory biomarker analysis
- Volunteers
- 55 people
- Sponsor
- Gynecologic Oncology Group
Cervical Intraepithelial Neoplasia
Randomized Clinical Trial on Clinical Management of ASCUS and LSIL (ALTS)
Approximately 65 million Pap smears are performed each year in the United States. The vast majority of results are negative (no abnormality identified) but about 5 percent to 8 percent are reported as abnormal.
- Trial name
- NCT01131312
- Testing
- Thinprep, Hybrid capture 2, Colposcopy
- Where
- 3 sites in United States
- Volunteers
- 5,060 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Abnormality
Community Awareness, Resources and Education (CARE I): Project 3
Community Awareness, Resources and Education (CARE) Project - Project 3 will determine if Appalachian women have unique risk factors for an abnormal Pap smear that might contribute to the increased risk of cervical abnormalities…
- Trial name
- NCT02113514
- Where
- 2 sites in United States
- Volunteers
- 2,394 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center