Clinical trials: Paracetamol Administration
Concussion, Headache
Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Concussions and headache are a significant problem for children and athletes. While headache generally resolves within 7-10 days; a significant proportion of children, 72-93% experience prolonged headache as a symptom of Post…
- Trial name
- NCT02268058
- Testing
- Acetaminophen, Ibuprofen
- Volunteers
- 80 people
- Sponsor
- McMaster Children's Hospital
Delirium, Aged
Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients
The primary aim of this interventional study is to investigate the impact of perioperative administration of Maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly…
- Conditions
- Delirium, Aged, Lung Neoplasms, Robotic Surgical Procedures
- Trial name
- NCT05834569
- Testing
- Acetaminophen and Ibuprofen, Normal saline
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Korea University Guro Hospital
Pain, Fever
Safety and Pharmacokinetic (PK) Study of Intravenous (IV) Acetaminophen Administration in Pediatric Inpatients
We are doing this study to find out what happens to acetaminophen in the body after it is given to children through the vein. Children's bodies may handle drugs differently than adults.
- Trial name
- NCT00493246
- Testing
- IV Acetaminophen
- Where
- 5 sites in United States
- Volunteers
- 75 people
- Sponsor
- Mallinckrodt
Pain Score Reduction, Effectiveness of Acetaminophen
Effectiveness Of Intravenous Vs Rectal Acetaminophen For Pain Management In Post Operative Neonates
This randomized controlled trial aims to evaluate the effectiveness of intravenous (IV) versus rectal acetaminophen for postoperative pain management in neonates.
- Conditions
- Pain Score Reduction, Effectiveness of Acetaminophen, Postoperative Pain Management in Neonates, Rescue Analgesia
- Trial name
- NCT06638086
- Testing
- Acetaminophen Suppositories, Acetaminophen Injection
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
Palliative Care
Paracetamol Route in Palliative Care Patients (PARASCIVPALLIA)
Background: Among palliative-care patients, subcutaneous route is often an alternative to intravenous route yet pharmacological and clinical data are lacking.
- Trial name
- PARASCIVPALL (NCT03944044)
- Testing
- Paracetamol route in palliative-care patients: intravenous versus subcutaneous route Pharmacokinetics study protocol
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Lumbar Disc Herniation
Tramadol vs.Tramadol With Paracetamol
This study focused on to determine postoperative analgesic efficacy of tramadol compared to tramadol with addition of paracetamol after a lumbar disc surgery.
- Trial name
- NCT03482492
- Testing
- Tramadol, Paracetamol
- Volunteers
- 60 people
- Sponsor
- Yeditepe University Hospital
Cholecystectomy, Laparoscopic, Cholecystectomy, Robotic
Opiranserin for Minimally Invasive Cholecystectomy
The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative…
- Trial name
- NCT07620665
- Testing
- Opiranserin+Acetaminophen, Acetaminophen+NSAIDs
- Where
- 2 sites in South Korea
- Volunteers
- 88 people
- Sponsor
- Gangnam Severance Hospital
Migraine Headaches
Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine
The objective of this randomized, double blind study is to demonstrate that one dose oral "excedrin migraine" (acetaminophen, aspirin and caffeine) is not inferior when compared to one dose of intravenous prochlorperazine for the…
- Trial name
- Migraine (NCT01629329)
- Testing
- Aspirin, Acetaminophen, Caffeine pills, Prochlorperazine 10mg
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Albert Einstein Healthcare Network
Pain, Migraine
Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine
The main purpose of this study is to compare the efficacy and safety of aspirin, acetaminophen and caffeine (AAC) with sumatriptan and placebo in the acute treatment of migraine.
- Trial name
- NCT01248468
- Testing
- Aspirin, acetaminophen and caffeine, Sumatriptan
- Where
- 20 sites in United States
- Volunteers
- 752 people
- Sponsor
- Novartis
Gastrointestinal Motility Disorder
Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water
To visualize the localization and to measure the volume of water in the small intestine by T2-weighted MRI imaging after oral administration of 240 ml water (non-caloric water) and after administration of 240 ml water containing…
- Trial name
- NCT01635608
- Testing
- Acetaminophen, Talinolol, Amoxicillin
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Fever
Pilot Study Comparison Of Intravenous Ibuprofen And Intravenous Paracetamol In Management Of Pediatric Fever
Fever is one of the most common reasons children are brought to emergency departments. Treatment of fever with antipyretics is usually done simply to make children more comfortable, although in some circumstances, such as febrile…
- Trial name
- NCT04123717
- Testing
- Intravenous Ibuprofen
- Where
- Qatar
- Volunteers
- 147 people
- Sponsor
- Hamad Medical Corporation
Moderate to Severe Chronic, Non-malignant Pain
Long Term Safety and Tolerability Study in Approximately 350 Subjects With Moderate to Severe Chronic, Non-malignant Pain
The purpose of the study is to evaluate the safety of Vicodin CR (combination opioid and acetaminophen containing product) in patients with chronic pain due to osteoarthritis or low back pain.
- Trial name
- NCT00195728
- Testing
- Hydrocodone/Acetaminophen on Extended Release
- Where
- 76 sites in United States
- Volunteers
- 431 people
- Sponsor
- Abbott
Postoperative Pain Management
Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery
Primary aim of this prospective, randomized, double-blind clinical trial is to compare the analgesic effects of intravenous paracetamol and ibuprofen on postoperative pain, and secondary aim is the effects on tramadol consumption…
- Trial name
- Ibuprofen (NCT05401916)
- Testing
- Tramadol, Paracetamol, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Bezmialem Vakif University
Chronic Pain
Treatment of Chronic Pain From Osteoarthritis
Osteoarthritis is a common joint disorder in the elder population.The current treatment options include both a non-pharmacological approach (physiokinesitherapy, diet) or if this fails, a pharmacological approach that relies in…
- Trial name
- NCT02032927
- Testing
- Codeine/paracetamol, Oxycodone/naloxone
- Where
- 14 sites in Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Orthodontic Pain (D013850), Pain Management (D016146)
A Randomized Clinical Trial of the Effectiveness of Acupressure in Relieving Orthodontic Pain
Orthodontic treatment with fixed appliances often causes pain, which peaks within 24 hours after archwire placement and lasts for several days.
- Conditions
- Orthodontic Pain (D013850), Pain Management (D016146), Acupressure (D056351), Analgesics, Non-Narcotic (D000700)
- Trial name
- NCT06812936
- Testing
- Acetaminophen, Acupressure
- Where
- Iraq
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Renal Colic, Urinary Calculi
Efficacy Study of Different Analgesic Options in Kidney Stone Pain Management
Abdominal pain is one of the most common presentations to an emergency department (ED). Among patients presenting with abdominal pain, a common diagnosis in the Middle East is renal colic (urolithiasis or Kidney stones).
- Trial name
- NCT02187614
- Testing
- Diclofenac, Morphine, Paracetamol
- Where
- Qatar
- Volunteers
- 1,645 people
- Sponsor
- Hamad Medical Corporation
Proximal Femur Fracture
Postoperative Pain Relieve for Patients Undergoing Surgical Treatment of Femoral Fracture
The aim of the study is to investigate postoperative pain relief for patients undergoing surgical treatment of proximal femoral fracture using intrathecal administration of morphine.
- Trial name
- NCT05920642
- Testing
- Intrathecal morphine administration, Parenteral administration of analgesics
- Where
- Czechia
- Volunteers
- 82 people
- Sponsor
- University Hospital Ostrava
Cold, Flu Symptom
Phase 3 Clinical Trial to Evaluate Paracetamol /Fexofenadine /Phenylephrine in Flu and Cold Treatment
A Phase 3, multicenter, Randomized, Double-blind, comparative clinical trial to evaluate the association of paracetamol 500mg + Fexofenadine 60mg + Phenylephrine 20mg in the flu and common cold treatment.
- Trial name
- RESFRIN (NCT05118672)
- Testing
- Experimental drug (paracetamol 500mg / fexofenadine 60mg / phenylephrine 20mg)
- Where
- 2 sites in Brazil
- Volunteers
- 567 people
- Sponsor
- Eurofarma Laboratorios S.A.
Sore Throat
Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat
Currently, paracetamol and nonsteroidal antiinflammatory drugs are widely used by emergency physicians in Turkey for the treatment of sore throat.
- Trial name
- NCT03768882
- Testing
- paracetamol, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Diabetic Peripheral Neuropathic Pain (DPN), Diabetic Peripheral Neuropathy
Transcutaneous Pulsed Radiofrequency for the Treatment of Diabetic Peripheral Neuropathy Pain
The purpose of this study is to determine if a non-invasive, electrical pulsed radio frequency (PRF) device can relieve pain and improve function in patients suffering from diabetic nerve pain in their feet, known as pedal…
- Conditions
- Diabetic Peripheral Neuropathic Pain (DPN), Diabetic Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain
- Trial name
- NCT07725419
- Testing
- NMS 460 Pulsed Radio Frequency Device
- Where
- 5 sites in South Africa
- Volunteers
- 92 people
- Sponsor
- Algiamed Technologies USA, Inc.