Clinical trials: Paracetamol Administration
Post-operative Pain
Efficacy of IV Acetaminophen for Pain Management
The investigators' goal in this planned prospective, randomized, patient blinded study is to compare our standard of care as the control group to an experimental group in which patients receive preemptive IV acetaminophen dosing…
- Trial name
- NCT02028715
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Aultman Health Foundation
Tonsil Disease, Pain Management
Analgesic Effects of Intranasal Diclofenac Sodium, Ibuprofen, and Paracetamol in Pediatric Tonsillectomy Cases
This study aims to evaluate the efficacy and safety of intranasal Diclofenac Sodium, intranasal Ibuprofen, and intranasal Paracetamol for pain control following tonsillectomy in pediatric patients.
- Conditions
- Tonsil Disease, Pain Management, Intranasal Drug Administration
- Trial name
- NCT06731556
- Testing
- Intravenous paracetamol, Intranasal Paracetamol, Intranasal Diclofenac Sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Fever
Treatment Of Fever In The Emergency Department
Fever is a frequent cause of admission to the Emergency Department (ED) around the world. While it can be caused by a wide range of conditions, the most effective treatment based on its etiology is still undetermined.
- Trial name
- NCT05814302
- Testing
- Paracetamol
- Where
- Italy
- Volunteers
- 324 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Pain Management
Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Hysterectomy
To compare the effects of intravenous paracetamol and ibuprofen on postoperative pain and morphine consumption in patients undergoing hysterectomy surgery and the side effects associated with opioids.
- Trial name
- ibupro-hyst (NCT04691856)
- Testing
- Morphine Sulfate, Intravenous paracetamol, Intravenous ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Inonu University
Migraine
A Study of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine
The purpose of this study is to test an experimental drug combination of two medications currently approved by the Food and Drug Administration (FDA) for migraine headache or other pain.
- Trial name
- NCT00300924
- Testing
- Rizatriptan co-administered with Acetaminophen
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- Diamond Headache Clinic
Tonsillitis, Airway Obstruction
Acetaminophen's Efficacy For Post-operative Pain
The purpose of this study is to compare IV acetaminophen to oral acetaminophen for pain control in children undergoing tonsillectomy with or without adenoidectomy.
- Conditions
- Tonsillitis, Airway Obstruction, Difficulty Swallowing
- Trial name
- NCT01721486
- Testing
- IV acetaminophen, PO acetaminophen
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Kaveh Aslani, MD
Post-op Pain
PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
The purpose of the study is to evaluate post-op pain requirements in patients undergoing hip or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV acetaminophen
- Trial name
- KHEA (NCT02244619)
- Testing
- Oral acetaminophen, IV acetaminophen
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Kettering Health Network
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pain, Postoperative
Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy
The purpose of this randomized, placebo controlled, single blind study is to determine if postoperative pain levels, as measured by a verbal numeric pain rating scale (VNRS), are reduced with the administration of IV…
- Trial name
- IVTYLENOL (NCT02025634)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- AdventHealth
Patent Ductus Arteriosus
PAIR (Paracetamol and Ibuprofen Research) Pilot Trial
Presence of Patent Ductus Arteriosus is detrimental to an infant born prematurely. The primary objective is to study the efficacy of Paracetamol (proposed new treatment) in treating haemodynamic significant Patent Ductus…
- Trial name
- PAIR (NCT04986839)
- Testing
- Paracetamol injection, Ibuprofen injection
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Manchester University NHS Foundation Trust
Pain
Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries
We compared the pain relief of acetaminophen with codeine versus ibuprofen for children ages 5-18 years who came to the Pediatric Emergency Department with injuries to their arms or legs.
- Trial name
- NCT00474721
- Testing
- ibuprofen, acetaminophen with codeine
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of California, San Diego
Pain Control Post Colorectal Surgery
Decrease Opioid Consumption With Intra-Venous (IV) Acetaminophen After Colorectal Surgery (DOCIVA)
The investigators hypothesis is that use of IV acetaminophen will significantly decrease use of post-operative opioid consumption and enhances recovery after colorectal surgery.
- Trial name
- DOCIVA (NCT02804633)
- Testing
- IV Acetaminophen
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Patent Ductus Arteriosus
Paracetamol and Patent Ductus Arteriosus (PDA)
The investigators propose that paracetamol will be similarly effective to ibuprofen in treating PDA in the premature neonate, with fewer side effects.
- Trial name
- NCT01291654
- Testing
- Paracetamol, NSAID, D5W
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Shaare Zedek Medical Center
Focus of Study: Pharmacokinetics Analysis, in Vivo Dissolution Studies
Pharmacokinetics of a Standard Paracetamol Tablet and Oral Solution After Oral Administration in Chinese Healthy Volunteers
Drug dissolution in vivo play a crucial role for the bioavailability and therapeutic of an orally administered solid dosage form.
- Trial name
- NCT02095704
- Testing
- paracetamol oral solution, paracetamol tablet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Central South University
Patent Ductus Arteriosus
Acetaminophen vs Indomethacin in Treating hsPDA
The purpose of this study is to see if acetaminophen (Tylenol) is as effective as indomethacin in closing patent ductus arteriosus in premature infants.
- Trial name
- NCT03537144
- Testing
- Indomethacin, Acetaminophen
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Tennessee
Pain Management
Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department
In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine.
- Trial name
- ADAMOPA (NCT04148495)
- Testing
- acetaminophen IV
- Where
- 11 sites in France
- Volunteers
- 415 people
- Sponsor
- Nantes University Hospital
Patent Ductus Arteriosus
Addition of Acetaminophen in Standard PDA Management
Patent ductus arteriosus is a common morbidity in preterm infants and management of PDA varies among neonatologist. The investigators are conducting a randomized controlled trial to determine the rates of initial patent ductus…
- Trial name
- NCT04026464
- Testing
- Intravenous Ibuprofen, Intravenous Ibuprofen + Oral Acetaminophen
- Sponsor
- University of Florida
Gastrointestinal Motility Disorder
Absorption of Paracetamol, Talinolol and Amoxicillin After Oral Administration Using Non-caloric and Caloric Water
To visualize the localization and to measure the volume of water in the small intestine by T2-weighted MRI imaging after oral administration of 240 ml water (non-caloric water) and after administration of 240 ml water containing…
- Trial name
- NCT01635608
- Testing
- Acetaminophen, Talinolol, Amoxicillin
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Pain
An Effectiveness and Safety Study Comparing Acetaminophen (3900 mg/Day) to Ibuprofen (1200 mg/Day) in the Treatment of Post-Race Muscle Soreness.
The purpose of this study is to compare the effectiveness and safety of acetaminophen extended release caplets and ibuprofen in relieving the muscle soreness that occurs after a marathon.
- Trial name
- NCT00240838
- Testing
- acetaminophen extended release caplets
- Volunteers
- 483 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington