Clinical trials: Paralysis
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Cerebral Palsy, Walking, Difficulty
A Motor Learning Intervention to Target Walking Performance in Ambulant Children With Cerebral Palsy
The goal of this clinical trial is to learn if a new therapy approach to improve walking ability in children with Cerebral Palsy is acceptable to the children and the families in a community setting.
- Conditions
- Cerebral Palsy, Walking, Difficulty, Spastic Diplegia, Hemiplegic Cerebral Palsy
- Trial name
- MOBILE (NCT06454656)
- Testing
- MOBILE
- Where
- Ireland
- Volunteers
- 14 people
- Sponsor
- Royal College of Surgeons, Ireland
Cerebral Palsy
Effects of Intensive Locomotor Treadmill Training on Gross Motor Function in Young Children With Neuromotor Impairment
The purpose of this project is to examine if early exposure to intensive, short-term locomotor treadmill training (LT) in young children with neuromotor impairment will help develop walking skills earlier, decrease the amount of…
- Trial name
- NCT01732731
- Testing
- treadmill training
- Volunteers
- 12 people
- Sponsor
- University of the Pacific
Neuromuscular Blockade
Sugammadex-dosing in Bariatric Patients
Should the dose of sugammadex in morbid obese patients be calculated on the real body weight or the ideal body weight? The main objective of the trial is to compare in patients undergoing bariatric surgery the efficacy of…
- Trial name
- SugReBaCh-1 (NCT01570179)
- Testing
- ideal BW based sugammadex reversal of moderate block, real body weight based sugammadex reversal of moderate block, real body weight based sugammadex reversal of deep block
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- Central Hospital, Nancy, France
Children With Cerebral Palsy
Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy (VERTEBRAL)
During the acquisition of posturokinetic abilities such as walking, postural control of the trunk is of paramount importance. Indeed, its development is strongly linked to the overall motor function of children.
- Trial name
- VERTEBRAL (NCT06320288)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Spastic Cerebral Palsy
Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy
We propose to identify patients and families for inclusion in pilot studies of the three modalities. Patients and their families will be asked to participate in these studies.
- Trial name
- NCT00011024
- Testing
- Self Hypnosis, Acupuncture, Osteopathic Manipulation
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Muscular Dystrophies, Spinal Muscular Atrophy
Schulze Muscular Dystrophy Ability Clinical Study
The primary objective of the Schulze study is to evaluate the function of the upper limbs of subjects diagnosed with neuromuscular disorders, with and without use of the Abilitech Assist device in the clinic and home…
- Conditions
- Muscular Dystrophies, Spinal Muscular Atrophy, Duchenne Muscular Dystrophy, Limb Girdle Muscular Dystrophy
- Trial name
- NCT05409079
- Testing
- Abilitech Assist
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- AbiliTech Medical Inc.
HEMIPLEGIC CEREBRAL PALSY
Efficacy of Lower Extremity Mirror Therapy on Balance in Children With Hemiplegic Cerebral Palsy
The study will be conducted to assess the efficacy of mirror therapy on balance in children with hemiplegic cerebral palsy.
- Trial name
- NCT04227262
- Testing
- MIRROR THERAPY
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- South Valley University
Diparesis, Cerebral Palsy
Lower Extremity Evaluation in Children With Diparetic Cerebral Palsy According to ICF Perspective
Cerebral palsy (CP); is the most common neurodevelopmental disorder seen in childhood, characterized by permanent motor dysfunctions that develop due to brain damage occurring before birth, during birth, or in early childhood.
- Conditions
- Diparesis, Cerebral Palsy, Diplegic Cerebral Palsy, Lower Extremity Paresis
- Trial name
- NCT06583746
- Testing
- Group1
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acıbadem Atunizade Hospital
Cerebral Palsy, Spastic
Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy
Children with Cerebral Palsy (CP), a condition that affects movement and coordination, face difficulties in daily activities such as dressing, reaching for objects in high places, and getting up from seats.
- Trial name
- INTERACT (NCT06571929)
- Testing
- INTERACT
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Paralysis, Hyperkalemic Periodic, Hypokalemic Periodic Paralysis
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dichlorphenamide for Periodic Paralyses and Associated Sodium Channel Disorders
OBJECTIVES: I. Assess the efficacy of dichlorphenamide in the treatment of episodic weakness attacks in patients with hyperkalemic periodic paralysis, paramyotonia congenita with periodic paralysis, and hypokalemic periodic…
- Conditions
- Paralysis, Hyperkalemic Periodic, Hypokalemic Periodic Paralysis, Paramyotonia Congenita
- Trial name
- NCT00004802
- Testing
- dichlorphenamide
- Volunteers
- 64 people
- Sponsor
- National Center for Research Resources (NCRR)
PolG, Primary Mitochondrial Myopathy
Prospective Natural History Study of POLG Disease
The PIONEER study is a prospective, natural history study dedicated to characterizing the clinical progression of POLG-related disorders.
- Trial name
- PIONEER (NCT07775872)
- Where
- 21 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- The POLG Foundation
Progressive Supranuclear Palsy
Study of Comprehensive ANd Multimodal Marker-based Cohort of Progressive Supranuclear Palsy(PSP)
The purpose of this cohort study is to develop a reliable biomarker in progressive nuclear palsy (PSP).
- Trial name
- SCAN-PSP (NCT05579301)
- Where
- 2 sites in South Korea
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Gross Motor Development Delay, Cerebral Palsy
Small Step Intervention for Infants With Cerebral Palsy and Other Neurodevelopmental Disorders
Children with cerebral palsy (CP) have life-long motor disorders and are typically subjected to extensive treatment throughout childhood.
- Trial name
- smallstep (NCT02166801)
- Testing
- Early intervention for infants, usual care
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Karolinska Institutet
Cortical/Cerebral Visual Impairment, Cerebral Palsy
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment
The goal of this study is to learn about eye gaze technology's use as an assessment and intervention of visual skills and the impact on occupational performance in children with cortical/cerebral visual impairment.
- Trial name
- NCT06067607
- Testing
- eye gaze technology
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockhurst University
Stroke, Hemiplegia
Task-Oriented Training Versus High-Intensity Gait Training in People With Chronic Stroke
The purpose of this study is to compare the effects of high-repetition task-oriented training and high-intensity gait training on walking capacity and functional mobility in individuals with chronic stroke.
- Conditions
- Stroke, Hemiplegia, Chronic Stroke
- Trial name
- NCT07725211
- Testing
- Neurodevelopmental Treatment, High-Repetition Task-Oriented Training, High-Intensity Gait Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University - Cerrahpasa
Cerebral Palsy, Lower Urinary Tract Symptoms
Incontinence and MRI Results in Children with Cerebral Palsy
More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment.
- Trial name
- NCT05060211
- Testing
- Vancouver symptom score for dysfunctional elimination syndroms, Magnetic resonance imaging
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- University Hospital, Ghent
Infant, Cerebral Palsy
Early Support and Physiotherapy for Children and Their Motor Skills
The App-eMot-Quali project proposed here is the first phase in the implementation of a care pathway supported by a digital tool.
- Conditions
- Infant, Cerebral Palsy, Neonatal
- Trial name
- App-eMot-Quali (NCT04523441)
- Testing
- Focus group, Semi-directive interview
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Bilateral Cerebral Palsy
Horizontal Versus Vertical Upper Extremity Function in Bilateral Cerebral Palsy
The goal of this quasi-experimental study is to investigate and compare the effects of horizontal and vertical upper extremity performance on hand skills and trunk control in children with bilateral spastic cerebral palsy; could…
- Trial name
- NCT07367477
- Testing
- a designed occupational therapy program to improvement hand skills conducted on a vertical surface., a designed occupational therapy (OT) program to improvement hand skills conducted on a horizontal surface.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Raghda Gamal Ateya Abd-Elbary
Otorhinolaryngologic Diseases
Reconstruction Implant Bone After Removal Using Porous Titanium Prosthesis
This trial will study the reconstruction of the anterior part of the mandible and the adjacent soft tissue parts by a mandibular prosthesis made in porous titanium, associated or not, to a latissimus dorsi or pectoral flap, to…
- Trial name
- NCT00213837
- Testing
- Mandibular prosthesis made of a new highly biointegratable material
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Strasbourg, France