Clinical trials: Paralysis, open to volunteers
Tetraplegia, Spinal Cord Injury
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
- Conditions
- Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury
- Trial name
- CRS-BMI (NCT01894802)
- Testing
- Implantation of CRS Arrays
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Michael Boninger
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Cerebral Palsy
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral palsy can make it difficult for children and adolescents to participate consistently in enjoyable physical activity. This study will examine whether a small humanoid robot called NAO can deliver a short, story-based…
- Trial name
- REACT (NCT07842328)
- Testing
- Humanoid Robot-Guided Active Play Intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries (SCI)
Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI
This clinical trial investigates whether combining cortical and spinal neuromodulation can improve upper limb motor recovery in adults with chronic incomplete cervical spinal cord injury (SCI).
- Trial name
- NCT07586644
- Testing
- Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- National University Hospital, Singapore
Quadriplegia
Visuomotor Prosthetic for Paralysis
The investigators objective is to run human clinical trials in which brain activity recorded through a "brain-chip" implanted in the human brain can be used to provide novel communication capabilities to severely paralyzed…
- Trial name
- NCT01958086
- Testing
- Neural Communication System
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Richard A. Andersen, PhD
Hemiplegia, Cerebral Palsy
Motus Nova Foot Device for Patients With Hemiplegia
Individuals with hemiplegia commonly demonstrate gait deviations such as difficulties with heel strike at initial contact, foot drop in swing, asymmetrical limb loading, muscle activation, and balance impairments.
- Conditions
- Hemiplegia, Cerebral Palsy, Hemiplegic Cerebral Palsy
- Trial name
- NCT07754773
- Testing
- Motus Nova Foot
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- MultiCare Health System Research Institute
Gait Impairment, Cerebral Palsy (CP)
Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting
The primary objective of the study is to validate the safety and clinical performance of the ABLE Kids device in pediatric patients with neurological gait disorders or muscular weakness during a 10-session gait training program…
- Conditions
- Gait Impairment, Cerebral Palsy (CP), Neuromuscular Diseases (NMD), Spinal Cord Injuries (SCI)
- Trial name
- NCT07745712
- Testing
- ABLE Kids
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- ABLE Human Motion S.L.
Unilateral Spastic Cerebral Palsy
Robotic Glove Training on Hand Function in Unilateral Cerebral Palsy
The purpose of the study is to investigate the effect of task-oriented robotic glove training on hand function in children with unilateral spastic cerebral palsy.
- Trial name
- NCT07482631
- Testing
- Conventional Physical Therapy Program, Robotic Glove Training
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Bell Palsy
Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's Palsy
Bell's palsy, a peripheral facial nerve paresis, is the most common disorder of the facial nerve and one of the most common mononeuropathies.
- Trial name
- NCT05821075
- Testing
- Prednisolone, Cerebrolysin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- October 6 University
Spastic Hemiplegic Cerebral Palsy
Effects of Sensory Integration Therapy in Children With Spastic Hemiplegic Cerebral Palsy
The Goal of this Clinical Trial is to learn if a treatmnet called Sensory Integration Therapy (SIT) can Improve walking,Balance and movemnet in children with a type of cerebral palsy called spastic hemiplegic Cerebral Palsy .This…
- Trial name
- NCT07733570
- Testing
- Sensory Integration Therapy, Conventional Physical Therapy
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Cerebral Palsy Infantile, Pre-Term
Motor-voice Assessment in Infants (MAMI)
The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants..
- Conditions
- Cerebral Palsy Infantile, Pre-Term, Motor Delay, Neurodevelopmental Disorders
- Trial name
- MAMI (NCT06807203)
- Testing
- Behavioral observation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Cerebral Palsy
Comparative Effect of CIMT and PNFTechnique on Hands Dexterity in Cerebral Palsy
Cerebral Palsy (CP) is a group of permanent disorders of the development of movement and posture, causing activity limitations that are attributed to non-progressive disturbances that occurred in the developing fetal or infant…
- Trial name
- NCT07673289
- Testing
- Constraint-Induced Movement Therapy, Proprioceptive Neuromuscular Facilitation Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Children With Cerebral Palsy
Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy
Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined…
- Trial name
- NCT07390760
- Testing
- Remote Ischemic Condtioning (RIC), Balance training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- East Carolina University
Oro-motor, MNRI
Effect of Masgutova Neurosensorimotor Reflex Integration on Oro-Motor Functional Skills in Children With Cerebral
Cerebral palsy (CP) is a disorder of movement and/or posture caused by a non-progressive brain lesion that persists through the lifespan and has a prevalence of more than 2 per 1000 live births (Oskoui et al., 2013).
- Conditions
- Oro-motor, MNRI, CP (Cerebral Palsy), OME
- Trial name
- NCT06838403
- Testing
- Oro motor excercise to study arms and controoled arms
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cerebral Palsy (CP), Unilateral Cerebral Palsy
tDCS and Bi-manual Training in Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function.
- Conditions
- Cerebral Palsy (CP), Unilateral Cerebral Palsy, Spastic Cerebral Palsy (sCP)
- Trial name
- NCT07573865
- Testing
- Anodal tDCS
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Riphah International University
Cerebral Palsy
Effects of Mirror Therapy on Lower Extremity in CP Children
A non-progressive condition that harms the developing brain both during and after birth is cerebral palsy (CP). It is a multifaceted syndrome marked by abnormalities in movement and posture, along with concomitant sensory-motor…
- Trial name
- NCT06673823
- Testing
- Mirror therapy, conventional therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Acute Spinal Cord Injury, Acute Spinal Paralysis
"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients.
- Conditions
- Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, Trauma, Spinal Cord
- Trial name
- SCRIBBLE (NCT05244408)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Hypoxic Ischaemic Encephalopathy (HIE), Premature Birth
Healing Tiny Minds: Rural Recovery Through Virtual and Lived Experience Care
The goal of this behavioral-interventional study is to learn if the Abecedarian Approach implemented virtually for children ages 0-5 with a history of Hypoxic Ischaemic Encephalopathy (HIE) and/or premature birth produces the…
- Conditions
- Hypoxic Ischaemic Encephalopathy (HIE), Premature Birth, Cerebral Palsy, Neurological Disorder
- Trial name
- NCT06643598
- Testing
- Abecedarian Approach
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- University of Wisconsin, Madison
Cerebral Palsy
Changes in Land-Based Motor Function After Routine Hydrotherapy in Children With Cerebral Palsy
This retrospective observational study aims to describe changes in land-based motor function recorded before and after routine hydrotherapy among children with cerebral palsy.
- Trial name
- CP-HYDRO-RETRO (NCT07907445)
- Testing
- Routine Hydrotherapy (Aquatic Rehabilitation)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Karabuk University