Clinical trials: Parasitic Infections
Falciparum Malaria
Artesunate+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria
In Afghanistan, studies over the past 15 years have shown a high degree of Plasmodium falciparum resistance to chloroquine (80%) and more recently an increasing degree of resistance to sulfadoxine-pyrimethamine monotherapy (12%).
- Trial name
- ASPF (NCT01115439)
- Testing
- artesunate plus sulfadoxine-pyrimethamine (AS+SP)
- Where
- 4 sites in Afghanistan
- Volunteers
- 100 people
- Sponsor
- University of Oxford
Falciparum Malaria
Study to Investigate the Induction of an Protective Immune Response to Malaria
The objective of the study is to induce a protective immune response against malaria in healthy human volunteers. The different parts of the immune response will then be studied.
- Trial name
- NCT00442377
- Testing
- exposure to malaria sporozoites
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pneumonia, Bacterial, Viral Infection
Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia
Clinical pneumonia is a leading cause of pediatric hospitalization. The etiology is generally bacterial or viral. Prompt and optimal treatment of pneumonia is critical to reduce mortality.
- Conditions
- Pneumonia, Bacterial, Viral Infection, Clinical Pneumonia, Plasmodium Falciparum Malaria
- Trial name
- NCT03996967
- Where
- 3 sites in United States, Netherlands and 1 more
- Volunteers
- 837 people
- Sponsor
- Boston University
Malaria
Innovation Platform
In this study, a prospective evaluation of novel malaria diagnostic tools under development will be performed in malaria-endemic countries to assess their clinical performance for detection of malaria at point-of-care (POC).
- Trial name
- NCT04558528
- Testing
- Novel in vitro diagnostics and medical applications
- Where
- 2 sites in Indonesia, Rwanda
- Volunteers
- 640 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Malaria, Malaria Vivax
This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax Malaria
The goal of this Phase 2b study is to examine the safety and efficacy of the combination of SJ733, an investigational agent, and tafenoquine for the radical cure of uncomplicated P.
- Conditions
- Malaria, Malaria Vivax, Radical Cure
- Trial name
- SJ733-2002 (NCT07430592)
- Testing
- CQ/TQ, SJ733 (3-day)/TQ, SJ733 (2-day ) /TQ
- Where
- Peru
- Volunteers
- 104 people
- Sponsor
- R. Kiplin Guy
Malaria
IPTi in Mozambican Infants for Malaria Prevention
To evaluate if intermittent preventive treatment in infants (IPTi) consisting of SP [Fansidar] given through the EPI scheme alongside routine immunisations at 3, 4 and 9 months of age reduces de incidence of clinical malaria up…
- Trial name
- NCT00209794
- Testing
- Sulfadoxine-Pyrimethamine (Fansidar)
- Where
- Mozambique
- Volunteers
- 1,498 people
- Sponsor
- Hospital Clinic of Barcelona
Healthy Volunteers
Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population
This study will test a new drug (MAM01) to find which doses are safe and could help prevent people from getting malaria for at least 4 months. The study will take place in parts of Africa where malaria is common.
- Trial name
- NCT06408857
- Testing
- MAM01 300 mg SC, MAM01 300 mg IM, MAM01 2000 mg IV
- Where
- 2 sites in Uganda
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Parasite and Infestation Physician-Patient Diagnostic Incongruency
The Parasite and Infestation Study
Many people have evidence of bugs, parasites, and infestation, but are told by others that they cannot find a cause. This distressing and frustrating experience can last for years, as the person seeks answers.
- Trial name
- NCT07849907
- Testing
- No intervention - observational study
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Malaria, HIV Infections
Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women
This study is an open-label, single site, randomized controlled trial comparing protease inhibitor (PI)-based antiretroviral therapy (ART) to non-PI based ART for HIV-infected pregnant and breastfeeding women of all CD4 cell…
- Trial name
- PROMOTE-PIs (NCT00993031)
- Testing
- Lopinavir/ritonavir, Efavirenz, Zidovudine
- Where
- Uganda
- Volunteers
- 389 people
- Sponsor
- University of California, San Francisco
Skin Diseases, Parasitic
Evaluation of a Rapid Diagnostic Device, CL Detect, for the Diagnosis of Cutaneous Leishmaniasis in Tunisia
The purpose of the study is to evaluate the sensitivity and specificity of CL Detect, in subjects with suspected CL in Tunisia.
- Trial name
- CL Detect™ (NCT01769612)
- Testing
- No Intervention
- Where
- 2 sites in Tunisia
- Volunteers
- 168 people
- Sponsor
- U.S. Army Medical Research and Development Command
Hookworm Infections
Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm
To compare the efficacy and safety of emodepside to that of albendazole (Zentel®) in participants aged 12-60, inclusive, infected with hookworm.
- Trial name
- NCT05538767
- Testing
- Emodepside, Albendazole 400mg
- Where
- Tanzania
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Malaria,Falciparum, Malaria
Mass Drug Administration of Dihydroartemisinin-piperaquine + Single Low-dose Primaquine to Accelerate Toward Elimination Activities
This community-based cluster randomized controlled trial aims to evaluate the effectiveness of time-limited, community-wide mass drug administration (MDA) with dihydroartemisinin-piperaquine (DHA-PPQ) and single low-dose…
- Trial name
- NCT04864444
- Testing
- Dihydroartemisinin-piperaquine, Primaquine
- Where
- Senegal
- Volunteers
- 10,715 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Plasmodium Falciparum Malaria
A Safety and Efficacy Study of Concomitant Administration of ChAd63/MVA ME-TRAP + RTS,S
The purpose of this study is to assess two types of new malaria vaccines in different combinations. The study will enable us to assess: 1. The ability of the vaccines to prevent malaria infection. 2.
- Trial name
- NCT02252640
- Testing
- RTS,S/AS01B (50mcg of RTS,S and standard adult dose of AS01), RTS,S/AS01B (10mcg of RTS,S and one fifth of the standard dose of AS01), ChAd63 ME-TRAP (5 x 10^10 vp)
- Where
- 4 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria,Falciparum
Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali
The purpose of this study is to compare the gametocytocidal and transmission reducing activity of artemether-lumefantrine (AL) with and without a single dose of 0.25mg/kg primaquine (PQ) and sulfadoxine-pyrimethamine with…
- Trial name
- NECTAR3 (NCT05081089)
- Testing
- Artemether-lumefantrine, Primaquine Phosphate, Sulphadoxine-pyrimethamine with amodiaquine
- Where
- Mali
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Anaemia, Malaria
Control of Pregnancy Associated Malaria With Intermittent Preventive Treatment
Malaria is one of the major causes of illness and mortality in Sub-Saharan Africa. In Ghana, malaria is the most important cause of morbidity and accounts for about 40% of outpatient contacts.
- Trial name
- NCT00258024
- Testing
- IPT-sulphadoxinepyrimethamine
- Where
- Ghana
- Volunteers
- 420 people
- Sponsor
- DBL -Institute for Health Research and Development
Mucocutaneous Leishmaniasis
Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis
This study is a Phase 4, open-label, single group study in which at least 40 adult patients undergoing miltefosine treatment for mucocutaneous leishmaniasis (CL and ML) will be assessed by 12-lead ECG for prolongation of the…
- Trial name
- NCT02429518
- Testing
- Miltefosine
- Where
- Bolivia
- Volunteers
- 42 people
- Sponsor
- Knight Therapeutics (USA) Inc
Vitamin A Deficiency, Malaria
Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method
For assessing body retinol pools in preschool children, it is recommended that a blood sample is taken 14-21 days after isotope dosing. During this period, dietary intake of vitamin A should be controlled.
- Conditions
- Vitamin A Deficiency, Malaria, Inflammation
- Trial name
- SUPERKID (NCT02996513)
- Testing
- Retinol Isotope Dilution (RID)
- Where
- Nigeria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Leishmaniasis, Cutaneous
Evaluation of the Safety and Clinical Activity of Curaleish in the Topical Treatment of Cutaneous Leishmaniasis.
Cutaneous Leishmaniasis (CL) is a parasitic disease caused by more than 15 different species of the protozoan parasite Leishmania.
- Trial name
- Curaleish (NCT04072874)
- Testing
- Experimental topical (Curaleish Topical)
- Where
- Colombia
- Sponsor
- Universidad de Antioquia
Malaria
Clinical Performance Evaluation of Fyodor Urine Malaria Test (UMT)
The purpose of this study is to evaluate the clinical performance of the one-step Fyodor Urine Malaria Test (UMT), to determine its accuracy (sensitivity and specificity) for the diagnosis of Plasmodium falciparum malaria in…
- Trial name
- NCT01921413
- Testing
- Urine Malaria Test
- Where
- Nigeria
- Volunteers
- 1,893 people, healthy volunteers welcome
- Sponsor
- Fyodor Biotechnologies Inc
Malaria
School Based Malaria Control in Ugandan Schoolchildren
The investigators hypothesize that schoolchildren treated with IPT using DP over one year of follow-up will have a different risk of clinical malaria compared to those treated with placebo.
- Trial name
- SBMC (NCT01231880)
- Testing
- Four monthly IPT with dihydroartemisinin Piperaquine (DP), Monthly IPT using DP
- Where
- Uganda
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Makerere University