Clinical trials: Parathyroid Adenoma
Parathyroid Adenoma, Thyroid Adenoma
Evaluation of a New CZT System
The purpose of the study is to check if the new CZT system has an advantage in detection of small osseous processes, thyroid adenomas, parathyroid adenomas and detection of sentinel node, in comparison with the techniques in use.
- Trial name
- NCT01084356
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Evaluation of the Role of IONM in Minimally Invasive Parathyroidectomy Performed for Solitary Parathyroid Adenoma
Evaluation of the Role of Intraoperative Neuromonitoring(IONM) in Patients Undergoing Parathyroid Surgery for Solitary Parathyroid Adenoma
Aim: Intraoperative neuromonitoring (IONM) is frequently used in cases of primary hyperparathyroidism (pHPT); however, its role in cases of solitary parathyroid adenoma has not been clearly defined, and differing opinions exist…
- Trial name
- NCT07836335
- Testing
- INTRAOPERATIVE NEUROMONITORING
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir Katip Celebi University
Primary Hyperparathyroidism
Cohort Trial on Perioperative Localization Techniques of Parathyroid Adenomas
A prospective database of consecutive patients with hyperparathyroidism subject to surgery is created. Preoperative workup and operative findings are recorded in this registry to allow comprehensive analysis.
- Trial name
- ParaCatI (NCT04013100)
- Testing
- 3D-VNE (virtual neck exploration)
- Volunteers
- 235 people
- Sponsor
- IHU Strasbourg
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Primary Hyperthyroidism
Localization of Parathyroid Adenoma by Fluorocholine PET/MRI (Positron Emission Tomography -MRI)
A comparative prospective study to evaluate different imaging modalities (pet-ct and pet-mr) prior to surgery in parathyroid tumor patients.
- Trial name
- NCT02843542
- Testing
- PET-MR, PET-CT
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assuta Medical Center
Thyroid Cancer, Thyroid Nodule
Minimizing Narcotic Analgesics After Endocrine Surgery
This research is being done to better understand and test if the investigators can minimize narcotic medication for controlling pain after thyroid or parathyroid surgery.
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Neoplasms, Thyroid Goitre
- Trial name
- NCT03469310
- Testing
- Acetaminophen 500Mg Cap, Tylenol #3 Oral Tablet, Tramadol
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Minerva A Romero Arenas
Parathyroid Adenoma
99mTc Sestamibi SPECT/CT vs 18F Fluorocholine PET/CT
This study proposes the use of a well-established PET isotope, Fluorine-18 (18F), bound to Choline, for a prospective single-center, single-arm study for participants with suspected parathyroid adenoma and negative or equivocal…
- Trial name
- 18FCH (NCT05891769)
- Testing
- 18Fluorocholine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Andrei Iagaru
Parathyroid Adenoma
Multicenter Registry Comparing Preoperative Imaging for Primary Hyperparathyroidism
The study aims are: 1. To compare the diagnostic performance of parathyroid four-dimensional CT (4D-CT), scintigraphy, and ultrasound in patients who underwent parathyroid surgery for primary hyperparathyroidism. 2.
- Trial name
- NCT02381925
- Sponsor
- Duke University
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Parathyroid Adenoma, Hypercalcemia
Preoperational Fine Needle Aspiration of Pathological Parathyroid Gland
Identification and localization of pathological parathyroid gland before parathyroidectomy is traditionally done by a combination of two methods: ultrasound and sestamibi scan.
- Trial name
- NCT03516747
- Testing
- pre operative parathyroid hormone level measurement, pre operative parathyroid cytology, parathyroid hormone level measurement
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Hyperparathyroidism, Primary, Parathyroid Neoplasms
WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making
Primary hyperparathyroidism is usually cured by removing the single over-active parathyroid adenoma. During surgery, however, surgeons often see a thin rim of normal parathyroid tissue that still "glows" under a near-infrared…
- Conditions
- Hyperparathyroidism, Primary, Parathyroid Neoplasms, Parathyroid Adenoma, Hypocalcemia
- Trial name
- WHITE CAP-PTS (NCT07043010)
- Testing
- Near-Infrared Parathyroid Tissue Sensor Imaging (PTS), Rim-Preservation Technique, En-bloc Resection Technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Parathyroid Adenomas
High Intensity Focused Ultrasound (HIFU) for Parathyroid Adenoma
This study aims to determine whether HIFU treatment is a safe and effective alternative to an operation to remove all or part of the affected gland.
- Trial name
- NCT01291498
- Testing
- High Intensity Focused Ultrasound
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Oxford University Hospitals NHS Trust
Primary Hyperparathyroidism, Parathyroid Adenoma
Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet.
The only known cure for primary hyperparathyroidism is surgical removal of one or more parathyroid glands. Some patients however, do not fulfill criteria for surgery or do not want to undergo a procedure due to fear of the…
- Conditions
- Primary Hyperparathyroidism, Parathyroid Adenoma, Parathyroid Hyperplasia
- Trial name
- DENOCINA (NCT03027557)
- Testing
- Cinacalcet 30 mg Tablet, Denosumab Inj 60 mg/ml
- Where
- Denmark
- Volunteers
- 46 people
- Sponsor
- Peter Vestergaard
Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma
Aldosterone Variations in Patients With Primary Hyperparathyroidism After Surgery
Primary hyperparathyroidism is a disorder of calcium and phosphorus metabolism linked to dysfunction of one or more parathyroid glands.
- Trial name
- ALDOPARA2 (NCT07388914)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Central Hospital, Nancy, France
Primary Hyperparathyroidism, Parathyroid Cancer
Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors
Background: People have 4 parathyroid glands near the thyroid gland in the neck. Surgery is needed to remove a parathyroid gland that is too large or has a tumor.
- Conditions
- Primary Hyperparathyroidism, Parathyroid Cancer, Multiple Endocrine Neoplasias, Heritable Hyperparathyroidism
- Trial name
- NCT07444723
- Testing
- 18F-FCH, NeuroEXPLORER
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Thyroid, Parathyroid Adenoma
Exparel Injection Effect on Postoperative Opioid Usage
The question proposed by this study, is one of patient outcomes. Does intraoperative injection of Exparel decrease postoperative use of opioid pain medications in patients undergoing thyroid and parathyroid surgery? The trial…
- Trial name
- NCT04085913
- Testing
- Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine, Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia