Clinical trials: Parathyroidectomy
Primary Hyperparathyroidism
EC17 for Intraoperative Imaging for Parathyroidectomy
Primary hyperparathyroidism is a significant medical and public health problem in the world and affects approximately 100,000 new patients in the United States alone.
- Trial name
- NCT01996072
- Testing
- EC17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Hyperparathyroidism, Secondary
Subtotal Parathyroidectomy or Total Parathyroidectomy With Autograft in Chronic Kidney Disease Patients Under Dialysis
This study evaluates the metabolic and clinical results of two well recognized and accepted surgical techniques in the management of severe hyperparathyroidism in patients under regular dialysis treatment.
- Trial name
- NCT02464072
- Testing
- Subtotal Parathyroidectomy, Total Parathyroidectomy + 45 autografts, Total Parathyroidectomy + 90 autografts
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- University of Sao Paulo General Hospital
Thyroid Diseases, Parathyroid Diseases
Ropivacaine Plus Magnesium Sulphate Infiltration
In the domain of endocrine gland surgery, thyroidectomy is the most common procedure. Patients report moderate to severe discomfort postoperatively, which is induced by a variety of mechanisms, the most common of which are…
- Conditions
- Thyroid Diseases, Parathyroid Diseases, Postoperative Pain, Anesthesia, Local
- Trial name
- NCT05294393
- Testing
- Ropivacaine 10%, Ropivacaine 10% plus magnesium sulphate 10mg/kg
- Where
- Greece
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Thyroidectomy, Paralysis of Vocal Cords
Performance of Ultrasound in the Early Diagnosis of Vocal Cords Paralysis
Thyroid and parathyroid surgery concerns around 50 000 patients a year in France. One of its main complications is paralysis of vocal cords, and the consequences can be serious.
- Trial name
- PECV (NCT03727217)
- Testing
- Pre and postoperative ultrasound
- Where
- France
- Volunteers
- 113 people
- Sponsor
- Lille Catholic University
Primary Hyperparathyroidism
Cohort Primary Hyperparathyroidism
CoHPT is a prospective, monocentric, observational cohort including all patients diagnosed with primary hyperparathyroidism in Nantes University Hospital, aiming to study the outcomes associated with parathyroidectomy.
- Trial name
- CoHPT (NCT05469087)
- Where
- France
- Volunteers
- 403 people
- Sponsor
- Nantes University Hospital
Parathyroid Adenoma, Parathyroid Neoplasms
Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy
This study will see if the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures is better…
- Conditions
- Parathyroid Adenoma, Parathyroid Neoplasms, Parathyroid Cancer, Hypercalcemia
- Trial name
- NCT05022641
- Testing
- PTeye, Standard of Care
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Michigan
Endstage Renal Disease
Parathyroidectomy in Endstage Renal Disease
To test the hypothesis that total parathyroidectomy retards cardiovascular calcification, improves bone mineral density, reduces cardiac hypertrophy and arterial stiffening in end-stage renal disease patients on maintenance…
- Trial name
- NCT00745719
- Testing
- parathyroidectomy
- Where
- Hong Kong
- Volunteers
- 122 people
- Sponsor
- The University of Hong Kong
Hyperthyroidism
Postoperative Hyperthyroidism
The purpose of this study is to evaluate the frequency and the clinical course of postoperative hyperthyroidism following surgery of tertiary hyperparathyroidism (THP) and to determine the diagnostic value of thyroglobulin in…
- Trial name
- NCT01095341
- Testing
- No intervention performed
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Heidelberg University
Primary Hyperparathyroidism
Feasibility of Parathyroidectomy With Exploration of 4 Parathyroid Glands in Outpatients
The development of outpatient surgery has become a national priority, with the objective of an ambulatory surgery rate of around 50% in 2016, whereas this rate reached only 37.7% in 2010.
- Trial name
- PARAMBU (NCT03732157)
- Testing
- outpatient management of parathyroidectomy, conventional management of parathyroidectomy
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Hyperparathyroidism, Thyroid Disease
Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery
The radio-guided technique offers both help with in-vivo identification and ex-vivo confirmation of parathyroid adenoma. In-vivo accuracy is most important but its results are not satisfactory.
- Conditions
- Primary Hyperparathyroidism, Thyroid Disease, Parathyroid Diseases, Parathyroid Adenoma
- Trial name
- NCT04344886
- Testing
- Conventional (dual-phase) SPECT/CT, Multi-phase SPECT/CT, Conventional minimally-invasive radio-guided parathyroidectomy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Primary Hyperparathyroidism
Effect of Parathyroidectomy on Cardiovascular Health
The aim of this study is to establish whether patients with mild primary hyperparathyroidism (PHPT) have an increased risk of cardiovascular diseases.
- Trial name
- NCT02989428
- Testing
- Early parathyroidectomy group (EPTX-group)
- Where
- Denmark
- Volunteers
- 69 people
- Sponsor
- University of Aarhus
Surgery
Bevonescein for Intra-Operative Nerve Visualization in Head and Neck Surgery
This protocol describes prospective, open-label, blinded, randomized controlled, multicenter pivotal studies to evaluate bevonescein.
- Trial name
- NCT05377554
- Testing
- Bevonescein, Intraoperative Visualization using White Light Reflectance (WLR) with Fluorescence (FL) Overlay, Intra-operative Visualization using White Light Reflectance (WLR)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Alume Biosciences, Inc.
Primary Hyperparathyroidism
Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary Hyperparathyroidism
Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity. The benefit of surgical treatment in this respect is unclear.
- Trial name
- NCT01057732
- Where
- Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Hyperparathyroidism
Effect of Parathyroidectomy on Sleep
Primary hyperparathyroidism (PHPT) is an endocrine disorder that disrupts calcium metabolism and has a broad range of clinical manifestations.
- Trial name
- NCT00501215
- Testing
- Parathyroid Surgery, Telephone Interview, Polysomnography (PSG)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Diseases, Parathyroid Diseases
The Analysis of Thyroidectomy and Parathyroidectomy
To analyze surgery or not, different surgical methods, timing of surgery, and alternative managements for patients of thyroid or parathyroid disease.
- Trial name
- NCT04569513
- Testing
- Thyroid and parathyroid disease
- Where
- Taiwan
- Volunteers
- 12,000 people
- Sponsor
- National Taiwan University Hospital
Recurrent Laryngeal Nerve Palsy, Postoperative Dysphonia
Post Thyroidectomy Echographic Method for Study of Vocal Fold Motion
One of the major risks of endocrine surgery is recurrent nerve palsy (RNP), leading to vocal folds (VF) immobility. It happens in 5% of cases, leading to high morbidity: dysphonia, aspirations, impossibility to work.
- Trial name
- VOCALE (NCT03976011)
- Testing
- Transcutaneous Laryngeal Ultrasonography
- Where
- 5 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperparathyroidism, Primary, Hypercalcemia
Efficacy and Safety Study of Cinacalcet for the Treatment of Hypercalcemia in Patients With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy
This study is designed to demonstrate the efficacy and to assess the safety of cinacalcet for the reduction of hypercalcemia in patients with primary hyperparathyroidism for whom parathyroidectomy is indicated on the basis of an…
- Trial name
- NCT00975221
- Testing
- Cinacalcet
- Where
- 47 sites in United States, Australia and 5 more
- Volunteers
- 67 people
- Sponsor
- Amgen
Quality of Life in Primary Hyperparathyroidism
Parathyroid Assessment of Symptoms French Version
Primary hyperparathyroidism has been associated with an impaired quality of life. Surgery has been suggested to improve this outcome in patients with baseline quality of life impairment; however, few studies have used specific…
- Trial name
- PAS_fr (NCT06450431)
- Testing
- SF-36 questionnaire French version and PAS.fr questionnaire
- Where
- France
- Volunteers
- 548 people
- Sponsor
- Nantes University Hospital
Primary Hyperparathyroidism
Bisphosphonate Prior to Parathyroidectomy in Primary Hyperparathyroidism
This study is a randomized, double-blinded, placebo-controlled trial investigating the effects of zoledronic acid (ZOL) versus placebo in patients with primary hyperparathyroidism (PHPT) undergoing parathyroidectomy (PTX).
- Trial name
- ZOLPHPT (NCT06859580)
- Testing
- Zoledronic acid 4 mg, Natriumklorid 9 mg/ml, Fresenius Kabi
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus