Clinical trials: Parkinson's Disease (PD), open to volunteers
Idiopathic Parkinson's Disease (PD)
Study on the Incidence of Malignant Neoplasms in Patients With Parkinson's Disease and Heterozygous Mutation of the GBA Gene
This multicenter retrospective observational study investigates the incidence of malignant neoplasms in Parkinson's disease (PD) patients carrying heterozygous pathogenic variants in the GBA1 gene.
- Trial name
- ONCOGBA (NCT06814431)
- Where
- 4 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Parkinson's Disease (PD), Deep Brain Stimulation
The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position
BACKGROUND: Parkinson's disease (PD) is a common movement disorder whose main symptoms include resting tremor, rigidity and bradykinesia.
- Trial name
- Microlesion Ef (NCT06685510)
- Testing
- the score of UPDRS item
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Parkinson's Disease (PD)
Low-Fidelity Driving Simulator Training in Parkinson's Disease.
The goal of this clinical trial is to learn if low-fidelity driving simulator training works to improve cognitive performance, driving behavior, and driving aptitude in individuals with Parkinson's disease.
- Trial name
- NCT07463755
- Testing
- Low-fidelity driving simulator training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Kansas Medical Center
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson's Disease (PD)
PET-MRI of Reward System in Parkinson's Disease With RBD
Impulse control disorders (ICDs) are frequently observed in Parkinson's disease (PD) and can have a major functional impact on the quality of life of both the patient and their entourage.
- Trial name
- RBD Impulse (NCT07213219)
- Testing
- PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging).
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Adjustment Disorder
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to…
- Trial name
- NCT07002034
- Testing
- RE104 for Injection
- Where
- 32 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reunion Neuroscience Inc
Parkinson Disease, Deep Brain Stimulation
Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation.
Parkinson's disease is a common, progressive neurodegenerative disorder. The degeneration of dopaminergic neurons is associated with characteristic clinical symptoms such as tremor, rigidity, slowness of movement (bradykinesia)…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, PD - Parkinson's Disease, PD
- Trial name
- EPA-DBS (NCT07838636)
- Testing
- Physiotherapy, Education about physiotherapy
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Medical University of Warsaw
Parkinson's Disease (PD)
The Effects of Ballet-Based Exercise Training on Respiratory Functions, Balance, Cognitive Functions, Peripheral Muscle Strength, Functional Capacity and Quality of Life in Patients With Parkinson's Disease
This study investigates the impact of an 8-week ballet-based dance therapy on people with Parkinson's disease. It aims to assess the effect of ballet on motor and non-motor symptoms, such as balance, cognitive function…
- Trial name
- NCT06986941
- Testing
- Ballet-Based Dance Therapy, Standard Care with Exercise Counseling
- Volunteers
- 24 people
- Sponsor
- Bezmialem Vakif University
Clozapine, Parkinson's Disease (PD)
Clozapine-related Immunodeficiency in Parkinsons Disease
Clozapine is a second generation antipsychotic drug used in psychiatry to treat schizophrenia, affective disorders or certain symptoms of dementia.
- Conditions
- Clozapine, Parkinson's Disease (PD), Immunodeficiency, Psychosis
- Trial name
- CLOZIDPD (NCT06634641)
- Testing
- blood test
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Parkinson's Disease (PD)
Parkinson's Research In Metagenomic Early Stage Biomarkers
This 2x2 factorial, randomized, controlled pilot study aims to identify a specific microbiota pattern, which could constitute a biomarker of Parkinson's disease, and to evaluate whether specific pathotypes can be associated with…
- Trial name
- PRIME_2025 (NCT07097103)
- Testing
- Mediterranean Diet Intervention, Intensive Physical Activity Intervention, Control
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson's Disease (PD)
Accelerated TMS for Freezing of Gait in Parkinson's Disease
The goal of this clinical trial is to learn whether a personalized brain stimulation method called repetitive transcranial magnetic stimulation (rTMS), combined with walking exercises, is a practical and tolerable approach to…
- Trial name
- TMS (NCT06982638)
- Testing
- TMS+ Gait training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Parkinson's Disease (PD)
Constant Current Versus Constant Voltage Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease
To compare the efficacy, programming burden, power consumption, and physicians' and patients' satisfaction between current mode and voltage mode of deep brain stimulation in each period one year after surgery.
- Trial name
- NCT06742450
- Testing
- Constant current (CC) subthalamic nucleus deep brain stimulation, Constant voltage (CV) subthalamic nucleus deep brain stimulation
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson's Disease (PD)
Prevention-in-PD-Study
The goal of this clinical trial (feasibility study) is to learn if a multimodal lifestyle program can improve adherence to recommended lifestyle changes in people with REM Sleep Behavior Disroder (RBD) or Parkinson's disease…
- Trial name
- NCT07297407
- Testing
- Multidomain lifestyle intervention
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- University Hospital Schleswig-Holstein
Parkinson Disease (PD)
Daily Amino Acid Supplementation for People With Parkinson's Disease
The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function.
- Trial name
- NCT07115563
- Testing
- Targeted Amino Acid Supplement
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cristina Colon-Semenza
Parkinson's Disease (PD)
Perception of Affordances and Obstacle Crossing in People With Parkinson's Disease and Healthy Adults
This study aims to explore how young adults, older adults and people with Parkinson's disease (PwP), perceive their abilty to cross obstacles while walking, and how this perception is related to their actual performance of…
- Trial name
- NCT06932679
- Testing
- Assessment of Gait and Visual Exploration
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Parkinson's Disease (PD)
Characterising Physiological Resilience in People With Parkinson's Disease
Parkinson's disease (PD) is a condition that affects movement and gets worse over time. It is more common in older adults. People with PD may have symptoms like shaking, stiff muscles, slow movement, and trouble with balance.
- Trial name
- ParkEx (NCT07013513)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Nottingham
Parkinson's Disease (PD)
Closed-Loop Therapeutic Refinement Using Local Field Potentials in Parkinson's Disease
This multi-center pilot study compares conventional DBS (cDBS) and adaptive DBS (aDBS) in Parkinson's disease patients using the Medtronic Percept™ system.
- Trial name
- CTRL-PD (NCT07105280)
- Testing
- Optimized conventional DBS, Optimized adaptive DBS
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- HagaZiekenhuis
Atypical Parkinsonism, Parkinson Disease (PD)
Standard Optimization of Stem Cells in Parkinson's Disease and Atypical Parkinsonism
The purpose of this study is to measure outcomes using intranasal and intravenous autologous bone marrow mesenchymal stem cells (BM-MSCs) for Parkinson Disease (PD) and Parkinson's Plus (PPS) patients.
- Trial name
- SO-ASC-INIVAT (NCT06858254)
- Testing
- Autologous mesenchymal stem cells
- Volunteers
- 60 people
- Sponsor
- Apeiron Research Center
Parkinson Disease, Parkinson's Disease (PD)
Developing Immersive Gamification Technology Systems For The Rehabilitation Management Of Adults With Parkinson's Disease (Phase 1 Trial)
This clinical trial aims to develop and test a prototype immersive gamification technology system (ImGTS) among healthy volunteers and to determine its acceptability, safety, and usability in a healthy population.
- Trial name
- NCT07382401
- Testing
- VR-HMD, AR-HMD, semi-CAVE
- Where
- Philippines
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augmented eXperience E-health Laboratory
Parkinson's Disease (PD)
Safety, Tolerability and Exploratory Efficacy of EC5026 in Parkinson's Disease (STEP Study)
The goal of this clinical trial is to learn if the oral drug candidate EC5026 is safe and targets the correct pathways to treat Parkinson's Disease in adults.
- Trial name
- STEP (NCT07142044)
- Testing
- EC5026 oral tablet
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- EicOsis Human Health Inc.