Clinical trials: Parkinson's
Parkinson Disease
Turkish Cognitive Self-Efficacy Questionnaire in Parkinson's Disease
This study aims to evaluate the validity and reliability of the Turkish version of the Cognitive Self-Efficacy Questionnaire in individuals with Parkinson's disease.
- Trial name
- NCT07488377
- Testing
- Cognitive Self-Efficacy Questionnaire (Turkish Version)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Parkinson's Disease, HIV Infections
Using Heavy Water to Study Cell Dynamics in Parkinson's Disease
This pilot study will assess the feasibility of using heavy water as a safe 'tracer' for biomarker studies of diseases of the brain and spinal cord, that, together, are also called the central nervous system (CNS).
- Trial name
- NCT00990379
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Salena Killion
Parkinson's Disease
Effects of Virtual Reality Based Training on Posture Stability in Parkinson's Disease
The present study is to examine the effects of a virtual reality based balance training using the Kinect sensor on postural stability and functional balance in individuals with Parkinson's disease.
- Trial name
- NCT02671396
- Testing
- Virtual reality based intervention, Conventional intervention
- Volunteers
- 20 people
- Sponsor
- National Yang Ming Chiao Tung University
Idiopathic Parkinson's Disease
MOTION, Safinamide in Early IPD, as add-on to Dopamine Agonist
Parkinson's disease is a major neurodegenerative disorder in which there is a progressive loss of nigrostriatal dopaminergic neurons.
- Trial name
- MOTION (NCT00605683)
- Testing
- Safinamide (as add-on therapy)
- Where
- 125 sites in United States, Argentina and 18 more
- Volunteers
- 679 people
- Sponsor
- Newron Pharmaceuticals SPA
Parkinson Disease
Optimising Community Resources and Support to Enhance Living With Parkinson's Disease
This is a multi-centre, single-blinded, randomized, controlled trial for PwPD (people with Parkinson's Disease) to compare (i) OPTIM-PARK II (a novel personalized treatment based on the latest published research evidence and…
- Trial name
- OPTIM-PARKII (NCT05583994)
- Testing
- Optim Park Intervention
- Where
- 4 sites in Spain, United Kingdom
- Volunteers
- 264 people
- Sponsor
- University of Southampton
Parkinson Disease
Evaluation of Ronnie Gardiner Method in Individuals With Parkinson's Disease
Parkinson's disease (PD) is typically associated with cognitive and movement related functional disabilities. One commonly described cognitive complaint is the ability to do several things simultaneously, defined as dual or…
- Trial name
- RGM/PD (NCT02999997)
- Testing
- Ronnie Gardiner Method (RGM)
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- University Hospital, Linkoeping
Parkinson's Disease (PD), Healthy Aging
Exoskeleton-Assisted Mobility in Aging and in Parkinson's Disease
This study will evaluate whether a wearable robotic exoskeleton can improve mobility, balance, and walking in healthy older adults and in individuals living with Parkinson's disease, populations at high risk of falls and mobility…
- Trial name
- NCT07567482
- Testing
- Exoskeleton
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre intégré de santé et de services sociaux de l'Outaouais
Parkinson Disease
NeuroGlove PD Study Clinical
Safety and Feasibility of Peripheral Sensory Stimulation of the Hand in the Treatment of Parkinson's Disease
- Trial name
- NCT06578273
- Testing
- NeuroGlove
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NeuroGlove LLC
Parkinson's Disease
Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease
This is an open-label cross-over randomized control study comparing the effect of modafinil and methylphenidate in patients with Parkinson's disease with excessive daytime sleepiness.
- Trial name
- NCT00393562
- Testing
- modafinil, methylphenidate
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease
The Clinical Profile of Parkinson Disease in Egypt
Multi-center, retrospective observational cohort study in 4 tertiary referral centers in Cairo over the period from 2004 to 2016. Study population. including all patients with idiopathic Parkinson disease attending.
- Trial name
- NCT03383497
- Volunteers
- 1,237 people
- Sponsor
- Cairo University
Cognitive Deficit
Deep Brain Stimulation (DBS) of the Nucleus Basalis of Meynert (NbM) in Patients With Parkinson's Disease
The existing DBS setting in patients with DBS of the globus pallidus interna (GPi), which aims to treat motor symptoms by a high-frequency stimulation, will be temporarily reprogramed to stimulate the NbM at a low frequency using…
- Trial name
- NCT02763397
- Testing
- NBM-DBS, DBS
- Volunteers
- 13 people
- Sponsor
- University Medical Center Groningen
Parkinson Disease
Patient Engagement Investigation of NMS Assist
Parkinson's can cause a wide range of non-motor symptoms (NMS), including pain and problems with mental health, memory and sleep. These affect the quality of life of people with Parkinson's (PwP) and their care partners (CP).
- Trial name
- NCT07038486
- Testing
- NMS Assist
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Newcastle University
Parkinson Disease
Stereotactic Intracerebral Injection of Allogenic IPSC-DAPs in Patients With Parkinson's Disease
Parkinson's disease is a progressive neurodegenerative disorder characterized by high morbidity due to the limited regenerative capacity of dopaminergic neurons in the brain.
- Trial name
- NCT07212088
- Testing
- ALC01 therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- iCamuno Biotherapeutics Ltd.
Parkinson's Disease, Multiple System Atrophy
Analysis of the Enteric Nervous System Using Colonic Biopsies
The aim of this project is to develop an original biomarker for Parkinson's disease (PD) and other parkinsonian syndromes (multiple system atrophy and progressive supranuclear palsy) based upon the detection of pathological…
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- ColoBioParker (NCT01353183)
- Testing
- colonoscopy or rectosigmoidoscopy
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Nantes University Hospital
Parkinson's Disease, REM Sleep Behavior Disorder
Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder
Up to 60% of Parkinson's Disease (PD) patients suffer from REM sleep behavior disorder (RBD), a parasomnia. This disorder is thought to be related to a dysfunction of limbic system and brainstem.
- Trial name
- MP-TCSP-IRMf (NCT02824341)
- Testing
- fMRI
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson's Disease with Cognitive Impairment, Healthy Elderly
Effectiveness of Attention/executivefunctions Training on Prospective Memory Abilities of Parkinson's Disease Subjects with Mild Cognitive Impairment and Healthy Aged Individuals: a Placebo-controlled Study with a Combined Immersive Virtual Reality and Telemedicine Approach
The goal of this randomized controlled trial is to evaluate the efficacy of attention and executive function training on prospective memory (PM) and executive functions in patients with Parkinson's disease and mild cognitive…
- Trial name
- NCT06801782
- Testing
- Experimental Cognitive training in Immersive Virtual Reality and Telemedicine approach, Active Comparator #1
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Parkinson Disease, Tremor
A Study of Suvecaltamide in Adults With Moderate to Severe Residual Tremor in Parkinson's Disease
This is a 17-week double-blind, placebo-controlled, randomized, flexible-dosing, parallel-group, multicenter study designed to evaluate the efficacy and safety of suvecaltamide for the treatment of moderate to severe residual…
- Trial name
- NCT05642442
- Testing
- Suvecaltamide
- Where
- 37 sites in United States, Germany and 2 more
- Volunteers
- 169 people
- Sponsor
- Jazz Pharmaceuticals
Parkinson's Disease
Repetitive Transcranial Stimulation (r-TMS) Treatment for Patients With Parkinson's Disease
The purpose of this study is to test the effects of deep rTMS using the novel H-coil on the motor, affective and cognitive deficits in patients with Parkinson's disease (PD) and to establish its safety in this population.
- Trial name
- r-TMS (NCT00625300)
- Testing
- repetitive transcranial stimulation (r-TMS), Repetitive transcranial stimulation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Parkinson Disease
Effects of Routine Physical Therapy With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Function in Patients With Parkinson's Disease
Objective of this study is to compare the effectiveness of routine physical therapy with and without Proprioceptive Neuromuscular Facilitation on Balance, gait and function in patients with Parkinson's disease.
- Trial name
- NCT05154552
- Testing
- Proprioceptive Neuromuscular Facilitation, Routine physical therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Lahore
Parkinson's Disease
Concurrent DBS Local Field Potential Analysis and Stimulation in a Closed-Loop Neuromodulation Device
The purpose of this clinical study is to allow the investigation of local field potential (LFP) signals in patients treated with DBS of the STN.
- Trial name
- NCT02731365
- Testing
- Activa PC+S
- Where
- United States
- Sponsor
- Vibhor Krishna
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