Clinical trials: Parkinson's Disease Patients, active
Parkinson Disease
Amyloid Monoclonal Antibody Treatment in PD Patients With Coexistent AD Pathology
This study aimed to determine the efficacy of amyloid clearance of lecanemab in patients with Parkinson's disease (PD) with amyloid co-pathology.
- Trial name
- NCT07544953
- Testing
- Lecanemab, Lecanemab non-administration group
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
PD - Parkinson's Disease
Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease
The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp.
- Trial name
- Subgaleal aDBS (NCT07398157)
- Testing
- Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Pain Management, Regional Anesthesia
Revision of Deep Brain Stimulator in Patients With Parkinson's Disease
Parkinson's disease is a chronic and progressive neurodegenerative disease that affects the central nervous system, particularly impairing movement control.
- Conditions
- Pain Management, Regional Anesthesia, Deep Brain Stimulation, Parkinsons Disease
- Trial name
- NCT07176494
- Testing
- Patients who underwent surgery under general anesthesia, Patients who underwent surgery under regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Parkinson's Disease
Telemedicine Intervention in Patients With Chronic Pain in PD
Pain is a very common and disabling symptom in Parkinson's disease, yet it is often untreated. This study will assess the impact of home-based physical and cognitive exercise interventions to reduce pain in this disease.
- Trial name
- NCT05410392
- Testing
- Physical exercise intervention, Cognitive exercise intervention, Health education
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Vibrotactile Coordinated Reset for the Treatment of Post Surgery Refractory Parkinson's Disease Patients
The purpose of our study is to evaluate Vibrotactile Coordinated Reset stimulation (vCR) and its effects on refractory post-surgery PD. vCR will be administered with a device called the Stanford Glove.
- Trial name
- NCT05558189
- Testing
- Vibrotactile Coordinated Reset (vCR)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Parkinson Disease(PD)
Rhythm Psychophysics With Parkinson's Patients
The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine.
- Trial name
- RPPD (NCT07647913)
- Testing
- Withholding Levodopa
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Parkinson's Disease (PD), Anxiety
Blood Flow Restriction Aerobic Exercise for Balance and Anxiety in Parkinson's Disease
Reducing balance problems and anxiety severity are the top two research uncertainties for people with Parkinson's disease (PD). Besides having a mutually aggravating relationship between postural impairment and anxiety severity…
- Conditions
- Parkinson's Disease (PD), Anxiety, Postural Balance
- Trial name
- NCT07831980
- Testing
- Aerobic Exercise with Blood Flow Restriction, Aerobic Exercise without Blood Flow Restriction
- Volunteers
- 54 people
- Sponsor
- National Cheng-Kung University Hospital
Idiopathic Parkinson's Disease (PD)
Study on the Incidence of Malignant Neoplasms in Patients With Parkinson's Disease and Heterozygous Mutation of the GBA Gene
This multicenter retrospective observational study investigates the incidence of malignant neoplasms in Parkinson's disease (PD) patients carrying heterozygous pathogenic variants in the GBA1 gene.
- Trial name
- ONCOGBA (NCT06814431)
- Where
- 4 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Parkinson Disease (PD), Gut Microbiota
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor…
- Conditions
- Parkinson Disease (PD), Gut Microbiota, Probiotic
- Trial name
- NCT07619560
- Testing
- Y7
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
Parkinson Disease, REM Sleep Behavior Disorder
Artificial Intelligence in Molecular Imaging: Predicting Parkinson's Risk in REM Sleep Behavior Disorder
The study aims to systematically document the course of REM sleep behavior disorder (RBD) and investigate possible clinical and imaging biomarkers for disease progression and conversion risk to Parkinson's disease (PD), dementia…
- Conditions
- Parkinson Disease, REM Sleep Behavior Disorder, Dementia, Lewy Body
- Trial name
- NUK-RBD (NCT06629207)
- Testing
- PET/CT with 18-FDG, SPECT : 123 I-FP-CIT (DATSCAN), MRI
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson's Disease (PD)
An Observational Study of Subcutaneous Infusion of ABBV-951 to Assess Change in Disease Activity and Adverse Events In Adult Japanese Participants With Advanced Parkinson's Disease
Parkinson's disease (PD) is a neurological condition, which affects the brain. Some symptoms of PD are tremors, stiffness, and slowness of movement.
- Trial name
- NCT05916157
- Where
- 17 sites in Japan
- Volunteers
- 250 people
- Sponsor
- AbbVie
Parkinson Disease, Parkinson Disease, Secondary
Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome.
- Trial name
- NCT07568067
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ke Dong, MD
Parkinson's Disease and Parkinsonism, Dysphagia
Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD
This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism.
- Trial name
- NCT07153692
- Testing
- tDCS, Conventional Dysphagia Treatment
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Wang Ping
Parkinson's Disease
The Relationship Between Homocysteine and Manifestation of Parkinson's Disease Patients
The aim of the current study is to investigate the association between blood homocysteine level and motor as well as cognitive manifestation of PD patients in Assiut governorate.
- Trial name
- NCT06849414
- Volunteers
- 44 people
- Sponsor
- Assiut University
Parkinson Disease
Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with…
- Trial name
- NCT07434089
- Testing
- C-Mill technology treadmill equipped with semi-immersive VR, C-Mill treatment without semi-immersive virtual reality (VR), Conventional physiotherapy training
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Healthy Volunteers, Parkinson's Disease Patients
Preparation and Feasibility of Exams for Expected Studies
Feasibility study: the examinations carried out as part of this protocol aim to carry out all the acquisitions and simulations of use, necessary for the development of the clinical research protocols to come to Clinatec (in…
- Conditions
- Healthy Volunteers, Parkinson's Disease Patients, Para/Tetraplegic Patients
- Trial name
- PRELUDE (NCT05698810)
- Testing
- CE marked Medical Device MagnetoEncephaloGraphy (MEG) usability, CE marked Medical Device Magnetic Resonance Imaging (MRI) usability, CE marked Medical Device ElectroEncephaloGraphy (EEG) usability
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
REal-life ON PARKinson's - ITaly (REONPARK-IT)
The present study aims to evaluate the effectiveness and safety of opicapone in a real-world setting at centers for Parkinson's disease located in Italy.
- Trial name
- NCT07403799
- Testing
- Opicapone 50 mg
- Where
- 20 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Bial - Portela C S.A.
Parkinson's Disease, Parkinsonism
VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism
VISMEMO-PD is an observational pilot study aimed at investigating visuospatial memory in reaching space and topographical memory in navigational space in patients with Parkinson's disease and Parkinsonism.
- Conditions
- Parkinson's Disease, Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- VISMEMO-PD (NCT07827963)
- Testing
- Multimodal visuospatial and topographical memory assessment
- Where
- 3 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
PARKINSON DISEASE (Disorder)
EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled Trial
The goal of this clinical trial is to evaluate the efficacy and safety of Crisugabalin in adult participants with Parkinson's disease suffering from nociceptive pain. The main question it aims to answer is: 1.
- Trial name
- RELIEF-PD (NCT07483398)
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Guangdong Provincial People's Hospital
Parkinson Disease
Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Parkinson's Disease Patients With Hypovitaminosis D
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male Parkinson's disease patients with hypovitaminosis D Main questions it aims to answer are: 1.
- Trial name
- NCT07084597
- Testing
- Vitamin D
- Where
- Bangladesh
- Volunteers
- 15 people
- Sponsor
- Bangladesh Medical University