Clinical trials: Parkinsons Disease (PD)
Parkinson Disease
TMS-related Measures as Biomarker of Cognitive Impairment in PD
The goal of the present study is to explore the diagnostic and prognostic value of neurophysiological biomarkers obtained through paired-pulse Transcranial Magnetic Stimulation (TMS) techniques in individuals affected by…
- Trial name
- SAI-PD22 (NCT06835595)
- Testing
- Transcranial Magnetic Stimulation
- Where
- 3 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Idiopathic Parkinson's Disease, Multiple Sclerosis
Online Cognitive Training in PD, MS and Depressed Patients Treated With Electroconvulsive Therapy
In Parkinson's disease, Multiple Sclerosis and depressed patients treated with electroconvulsive therapy, cognitive dysfunction is prevalent. However, treatment of these dysfunctions is in its infancy.
- Conditions
- Idiopathic Parkinson's Disease, Multiple Sclerosis, Elderly Post Electric Convulsive Therapy
- Trial name
- NCT02525367
- Testing
- Online cognitive training, Active control condition
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Amsterdam UMC, location VUmc
Parkinson Disease
A Trial Investigating Lu AF28996 in Adult Japanese Participants With Parkinson's Disease (PD)
This trial will evaluate the effects of Lu AF28996 in adult Japanese men and women with Parkinson's disease (PD). The main goals of the trial are to learn more about a) the safety and tolerability of Lu AF28996 (any new or…
- Trial name
- NCT06004180
- Testing
- Lu AF28996
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- H. Lundbeck A/S
Parkinson's Disease (PD)
To Assess Self-sufficiency in Parkinson's Patients and How Rehabilitation Affects Symptoms Linked to Independence
This interventional study aims to assess self-sufficiency in patients with Parkinson's disease in the spa setting using the new Czech Functional Efficiency of Self-sufficiency Test (FEST) and to validate the test in this…
- Trial name
- NCT07872202
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Palacky University
Parkinson's Disease (PD), Healthy Control Subjects
This Protocol is a Sub-study Under the PPMI Program. It is a Longitudinal, Single-center Study to Assess the Performance of [18F]AV-133 Imaging Using High and Standard Resolution PET in Individuals Enrolled With Parkinson's Disease (PD) for up to 12 Months.
The study is a longitudinal, single-center study to assess progression of [18F]AV-133 imaging in PD participants. Participants will be followed for up to 12 months.
- Trial name
- NCT07830654
- Testing
- [18F]AV-133
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson's Disease
Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients With "Wearing-off" Phenomenon
This study aims to demonstrate the efficacy and safety of BIA 9-1067, compared with entacapone or placebo, when administered with the existing treatment of L-DOPA plus a Dopa Decarboxylase Inhibitor (DDCI), in patients with…
- Trial name
- NCT01568073
- Testing
- BIA 9-1067, Entacapone, Levodopa
- Where
- Portugal
- Volunteers
- 600 people
- Sponsor
- Bial - Portela C S.A.
Parkinson's Disease (PD)
Efficacy of LSVT-LOUD Therapy on Voice, Speech, and Quality of Life in Parkinson's Disease
Parkinson's disease often causes speech and voice impairments, such as reduced vocal loudness and decreased speech intelligibility, which significantly impact the quality of life for patients and their families.
- Trial name
- NCT07730073
- Testing
- LSVT-LOUD Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Atlas University
Parkinson Disease, Parkinson
Treatment Burden in Parkinson's
Background: People with Parkinson's (PwP) have many symptoms including tremor, stiffness, slow movements, constipation, urinary incontinence and mental health issues.
- Trial name
- NCT04769973
- Where
- 2 sites in United Kingdom
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Idiopathic Parkinson's Disease
Infusion of Apomorphine: Long-term Safety Study
This is a Phase 3, multicenter, open-label, safety and tolerability study of continuous apomorphine infusion in subjects with advanced Parkinson's Disease (PD) whose motor fluctuations remain unsatisfactory with levodopa (or…
- Trial name
- INFUS-ON (NCT02339064)
- Testing
- apomorphine infusion
- Where
- 18 sites in United States
- Volunteers
- 99 people
- Sponsor
- MDD US Operations, LLC a subsidiary of Supernus Pharmaceuticals
Parkinson Disease
Can Dance Therapy Improve Motor Learning in Parkinson's Disease (PD)?
In order to find the most effective rehabilitative therapies for Parkinsonian patients, the present study is aimed to evaluate whether, in a multidisciplinary intensive rehabilitation treatment, the dance therapy, applied to the…
- Trial name
- NCT03549793
- Testing
- Dance Therapy, exercises without dance
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson's Disease (PD), Dementia
Clinical Validation of AI-powered Smart Vehicle Assisted Gait Training in Neurodegenerative Disorders
This study aims to verify the safety and preliminary clinical benefits of long-term gait training using AI-powered smart electric vehicles for patients with neurodegenerative diseases such as Parkinson's disease and dementia.
- Trial name
- NCT07230366
- Testing
- BestShape Go Intelligent Generation Transformable Electric Vehicle
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Parkinson's Disease (PD)
A Study to Evaluate the Efficacy and Safety of ENERGI-F705 Tablets for Parkinson's Disease
The goal of this clinical trial is to learn if this study drug, ENERGI-F705 Tablets, is safe and works to treat participants who have Parkinson's disease and are currently on standard-of-care antiparkinsonian medications.
- Trial name
- NCT07647614
- Testing
- 60 milligrams of ENERGI-F705 Tablets, 120 milligrams of ENERGI-F705 Tablets
- Where
- 2 sites in Taiwan
- Volunteers
- 105 people
- Sponsor
- Energenesis Biomedical Co., Ltd.
Parkinson Disease
Adaptive DBS to Offset STN Dysregulation During Exercise in PD
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
- Trial name
- NCT06296810
- Testing
- aDBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease, Deep Brain Stimulation
Programming Strategy of VFS for Gait Impairments in PD
Variable Frequency Stimulation(VFS) is a stimulation pattern applied in Deep Brain Stimulation(DBS) therapy for Parkinson's disease(PD). Peking Union Medical College Hospital was the first centre conducting research on VFS.
- Conditions
- Parkinson's Disease, Deep Brain Stimulation, Gait Disorders, Neurologic
- Trial name
- NCT05905198
- Testing
- Programming
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Parkinson's Disease (PD)
Pairing Subjective Patient Rating and DBS Programming
This multicenter, prospective and retrospective diagnostic study investigates personalized programming strategies for deep brain stimulation (DBS) in patients with Parkinson's disease.
- Trial name
- PERCEPT-DBS (NCT07336199)
- Testing
- No intervention (observational study)
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Parkinson's Disease (PD), Alzheimer's Disease (AD) and Related Disorders
Moving Yourself in Space and Time: MYSTIC
This study is being done to answer the question: Do people with Parkinson's benefit from a new stepping therapy, and how do people with Parkinson's best learn new steps and rhythms set to music? Researchers will also compare…
- Conditions
- Parkinson's Disease (PD), Alzheimer's Disease (AD) and Related Disorders, Older Adults (60 - 85 Years Old)
- Trial name
- MYSTIC (NCT07697664)
- Testing
- Complex Rhythmic Movement Sequences (CRMS) Sessions
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Emory University
Parkinson Disease (PD), Cognition
Short Term Effects of a Multimodal Intervention With RGM on Cognition in People With Parkinson's Disease.
The goal of this clinical trial is to learn if the Ronnie Gardiner Method (RGM) works to improve cognitive functions in adults with Parkinson's disease (early to mid-stage).
- Conditions
- Parkinson Disease (PD), Cognition, Quality of Life, Functional Mobility
- Trial name
- NCT07863219
- Testing
- Ronnie Gardiner Method
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Ghent
Idiopathic Parkinson's Disease (PD)
Study on the Incidence of Malignant Neoplasms in Patients With Parkinson's Disease and Heterozygous Mutation of the GBA Gene
This multicenter retrospective observational study investigates the incidence of malignant neoplasms in Parkinson's disease (PD) patients carrying heterozygous pathogenic variants in the GBA1 gene.
- Trial name
- ONCOGBA (NCT06814431)
- Where
- 4 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Parkinson's Disease (PD)
Health Related Quality of Life in LCIG Patients and LCIG Eligible Patients Continuing Oral Therapy
The aim of this study is to assess the effect of LCIG (levodopa-carbidopa intestinal gel) on HRQL (Health-Related Quality of Life) of participants and compare the Health-Related Quality of Life between participants continuing to…
- Trial name
- BALANCE (NCT02381444)
- Where
- 27 sites in Germany, Switzerland
- Volunteers
- 136 people
- Sponsor
- AbbVie
Parkinsons Disease (PD), Anxiety
TMS in Anxiety-Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Anxiety in PD is common, has major effects on quality of life and contributes to increased disability.
- Trial name
- NCT06999330
- Testing
- Theta burst stimulation active coil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HealthPartners Institute