Clinical trials: Parodontitis
Apical Periodontitis, Pulp Disease, Dental
A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
The goal of this observational is study is to develop a protocol for root canal biofilms disinfection using a clinically approved and commercially available iron oxide nanoparticle formulation Ferumoxytol/H2O2 treatments.
- Trial name
- NCT06110494
- Testing
- Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cryotherapy
Effect of Cryotherapy on Post-endodontic Pain
The goal of this clinical trial is to compare Cryotherapy with occlusal reduction in the reduction of post-endodontic pain in molars with symptomatic apical periodontitis.
- Trial name
- NCT05722704
- Testing
- Cryotherapy, Occlusal reduction
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of…
- Trial name
- EIPRFITCP (NCT04178590)
- Testing
- SRP + Injectable Platelet-Rich Fibrin
- Where
- Serbia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Aggressive Periodontitis
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis…
- Trial name
- NCT02969928
- Testing
- Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Aggressive Periodontitis
Clarithromycin as Adjuvant to Periodontal Debridement
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.
- Trial name
- NCT02829983
- Testing
- Clarithromycin, One-stage full-mouth ultrasonic debridement (FMUD)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Residual Disease, Aggressive Periodontitis
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to…
- Trial name
- NCT03093207
- Testing
- Open flap debridement, Omega-3 polyunsaturated fatty acids, Aspirin
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periodontal Diseases
Lactobacillus Reuteri in the Supportive Therapy of Periodontitis
Literature shows the potential effectiveness of L. reuteri as an adjunct to non-surgical periodontal therapy in initial treatment of periodontitis, but also underlines the limits of the conclusions, and the heterogeneity and…
- Trial name
- PERIOPRO (NCT04478643)
- Testing
- Probiotic: Lactobacillus Reuteri
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Periodontitis
Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population
Clinical research study to determine the effectiveness of a triclosan/copolymer/fluoride toothpaste in maintaining periodontal health and therefore glycaemic control in a type 2 diabetic population.
- Trial name
- NCT00762762
- Testing
- Triclosan/copolymer/fluoride, Fluoride
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Chronic Periodontitis
Role of Infected Blood Dendritic Cells in Heart Disease Risk
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
- Trial name
- NCT01568944
- Testing
- Oral Antibiotic and Oral Rinse, Standard Treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Augusta University
Periodontitis
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Chronic periodontitis is an infectious disease of periodontal support tissues caused by bacterial biofilm, which leads to inflammation and destruction of periodontal support tissues ultimately resulting in tooth loss.In the…
- Trial name
- NCT05530252
- Testing
- Oral biological antimicrobial gel, minocycline hydrochloride ointment, SRP
- Where
- China
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Hyperlipidemia, Periodontitis, Gingivitis
PERIODONTAL DISEASE AND HYPERLIPIDEMIA
The investigators hypothesized that hyperlipidemia as an unfavourable levels of lipoprotein subfractions have deleterious impact on the development of periodontal infection by altering oxidative stres status of periodontal…
- Trial name
- NCT02808130
- Testing
- hyperlipidemia, periodontitis, gingivitis
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Chronic Periodontitis
Combined Use of Er:YAG and Nd:YAG Laser
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
- Trial name
- NCT02851823
- Testing
- Periodontal curettes, Er-YAG+Nd-YAG lasers
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Gingival Diseases
Collection of Gingival Crevicular Fluid From Periodontitis Patients
To collect GCF (gingival crevicular fluid) samples from diseased patients suffering only from gingivitis and/or periodontitis.
- Trial name
- NCT00763048
- Testing
- Fluoride, Fluoride, triclosan
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontitis
Emdogain Minimally Invasive Surgical Technique
The aim of this controlled study is to assess the clinical outcomes and patient reported outcomes of using minimally invasive surgical procedure with Straumann Emdogain as an adjunct (test treatment) or without Straumann Emdogain…
- Trial name
- NCT02551770
- Testing
- Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Periodontitis, Gingivitis
The Effects of DHA on Periodontitis
The purpose of this study is to determine whether docosahexaenoic acid (DHA) is effective in the treatment of periodontitis in adults.
- Conditions
- Periodontitis, Gingivitis, Inflammation
- Trial name
- DAP (NCT01976806)
- Testing
- Aspirin, Docosahexaenoic acid
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Peri-Implantitis, Periodontitis
Macrophage Markers in Periodontal and Peri-implant Health and Disease
Macrophage surface markers (CD80, CD163 and CD206) will be evaluated in periodontally healthy gingiva, healthy peri-implant mucosa, and periodontitis and peri-implantitis lesions.
- Trial name
- NCT05242354
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
The use of lasers to treat various problems in dentistry is growing as it has in medicine. One application is the use of lasers to treat periodontal disease.
- Trial name
- NCT04027686
- Testing
- Laser Therapy, Non-surgical Scaling and Root Planing
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles