Clinical trials: Parodontitis
Furcation Defects, Periodontitis
Treatment of Advanced Grade III Periodontal Furcation Lesions
Periodontitis, a microbially-driven inflammatory disease has been shown to be the sixth most common disease of mankind. The 2009 UK Adult Dental Health Survey found that 54% of adults experience gum bleeding (gingivitis) with 45%…
- Conditions
- Furcation Defects, Periodontitis, Surgical Procedure, Unspecified, Periodontal Bone Loss
- Trial name
- NCT05237739
- Testing
- Non-Surgical Periodontal treatment (NSPT), Open Flap Debridement (OFD)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College London
Acute Myocardial Infarction (AMI), Periodontal Disease
Myocardial Infarction and Periodontitis: Periodontal Health Intervention.
The aim of this study is to establish a shared database of acute myocardial infarction patients with periodontitis, to clarify the clinical benefits of periodontitis intervention on acute myocardial infarction patients through…
- Trial name
- NCT06745141
- Testing
- Periodontal surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Stress, Psychological, Periodontal Diseases
Effect of Stress on Periodontal Therapy (NPT)
Aim of this study: is to evaluate the influence of stress level on the response of non surgical periodontal therapy in patients affected by severe periodontitis divided into "Medium/High stress level" or "Low stress level" based…
- Conditions
- Stress, Psychological, Periodontal Diseases, Periodontitis, Non Surgical Periodontal Therapy
- Trial name
- NCT04739475
- Testing
- Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Turin, Italy
Generalized Aggressive Periodontitis
Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment
This study is designed as a parallel, masked, randomized, placebo-controlled clinical trial to assess the clinical, microbiological, and immunological outcomes of scaling and root planning (SRP) or full-mouth ultrasonic…
- Trial name
- NCT03933501
- Testing
- amoxicillin and metronidazole
- Volunteers
- 48 people
- Sponsor
- University of Campinas, Brazil
Periodontal Diseases, Periodontal Inflammation
Oral and Systemic aMMP-8 in Periodontal Disease
Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health.
- Trial name
- NCT04268381
- Testing
- Biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis, Smoking
Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis
This study comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects.
- Trial name
- NCT03426241
- Testing
- no intervention
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baskent University
Arthritis, Rheumatoid, Periodontitis
Periodontal Therapy in Patients With Rheumatoid Arthritis
Aim: A prospective randomized, controlled clinical trial comparing two groups of a cohort of Rheumatoid Arthritis (RA) patients with periodontal disease will be carried out to identify if the effect of non-surgical periodontal…
- Trial name
- NCT05502601
- Testing
- Non-surgical periodontal treatment
- Where
- Peru
- Volunteers
- 42 people
- Sponsor
- Federal University of Rio Grande do Sul
Chronic Periodontitis (CP) Subjects.
"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."
Aim: To evaluate effect of non- surgical periodontal therapy on liver function in systemically healthy chronic periodontitis (CP) subjects.
- Trial name
- NCT02583841
- Testing
- Scaling and root planing
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Irreversible Pulpitis, Apical Periodontitis
Healing Outcomes Following Hydraulic Condensation With a Bioactive Bioceramic Sealer in Root Canal Treatment
This prospective clinical study aimed to evaluate the healing outcomes after root canal treatment using a bioceramic sealer called BioRoot RCS in combination with a technique known as hydraulic condensation.
- Trial name
- HEAL-BR (NCT07075354)
- Testing
- Hydraulic Condensation Root Canal Obturation with BioRoot RCS
- Where
- Bulgaria
- Volunteers
- 66 people
- Sponsor
- Plovdiv Medical University
Post Operative Pain, Inflammation
Postoperative Pain Assessment After Canal Preparation by Different NiTi File Systems
The participants were divided into two groups : group one ( Trunatomy file group)(n=10) was mechanically prepared the canals by Trunatomy file and group two ( Edgeendo x7 file group) ( n=10) was prepared the canals by Edgeendo x7…
- Trial name
- NCT06286995
- Testing
- Chemomechanical preparation for root canals
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Rheumatoid Arthritis, Periodontitis
Relationship of Periodontitis and Cardiovascular Risk in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is one of the most common autoimmune inflammatory arthritis affecting 0.5 to 1% population worldwide characterized by synovitis, increased inflammatory markers and progressive bone and cartilage erosion.
- Trial name
- NCT03506165
- Testing
- Periodontal treatment
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Bruxism, Periodontitis
Electromyographic Assessment of Sleep Bruxism in Patients With Stage III and IV Periodontitis
This study aims to investigate the association between periodontitis Stage III and IV and the intensity and duration of sleep bruxism episodes.
- Conditions
- Bruxism, Periodontitis, Sleep Bruxism
- Trial name
- NCT07053865
- Testing
- Surface Electromyography (dia-BRUXO)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Siena
Revascularization
Regeneration of Immature Teeth. Case Series
This clinical study aims to investigate the predictability of revascularization procedure of immature necrotic human permanent teeth with apical periodontitis.
- Trial name
- NCT03507556
- Testing
- Triple paste and induced bleeding, Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol
- Where
- Jordan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Pain Postoperative
Foraminal Enlargement and Postoperative Pain.
The purpose of this study is to determine whether enlarging the apical foramen causes postoperative pain in teeth with necrotic pulp and apical periodontitis.
- Trial name
- NCT02770053
- Testing
- Foraminal enlargement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Apical Periodontitis, Endodontic Disease
Nanozymes in Endodontics
The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment.
- Conditions
- Apical Periodontitis, Endodontic Disease, Root Canal Infection
- Trial name
- NCT07518901
- Testing
- Nanozyme treatment, Control (Standard treatment)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Periodontitis, Gingivitis
PTPIP51-VAPB Complex in the Periodontal Disease
Gum disease, including gingivitis and more advanced periodontitis, is a common condition that damages the tissues supporting the teeth.
- Trial name
- NCT07705048
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Heart Transplant Failure, Periodontitis
Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients
Inflammation plays a key role in the deterioration of chronic heart transplants. Periodontal disease is not limited to the tooth-supporting structures - it also contributes to systemic inflammation.
- Conditions
- Heart Transplant Failure, Periodontitis, Crp
- Trial name
- NCT03671408
- Testing
- clinical measurements
- Volunteers
- 33 people
- Sponsor
- Baskent University
Treatment of Periodontitis, Guided Biofilm Therapy
Comparison of Current Subgingival Debridement Methods
Our study aimed to compare the effectiveness of current subgingival debridement methods used in the treatment of Stage 1 and Stage 2 periodontitis patients, the aesthetic condition achieved after these treatments, and the pain…
- Conditions
- Treatment of Periodontitis, Guided Biofilm Therapy, Subgingival Plaque, Subgingival Debridement
- Trial name
- NCT06835452
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Chronic Periodontitis
Influence of Gingival Biotype on the Outcome of Open Flap Debridement
The influence of periodontal thickness has been documented in outcome of various periodontal interventions like non surgical periodontal therapy, mucogingival therapy, guided tissue regeneration (GTR), crown lengthening and…
- Trial name
- NCT03882138
- Testing
- open flap debridement
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Generalized Adult Periodontitis
Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals
50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
- Trial name
- SEGPPAH (NCT02423304)
- Testing
- blood samples collected from all patients
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
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