Clinical trials: Parodontitis
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periodontitis, Periodontitis Stage I
Chlorhexidine and Zinc in Non-Surgical Periodontal Therapy
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth and is associated with both local tissue destruction and systemic inflammatory responses.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II
- Trial name
- CHX-Zn (NCT07517991)
- Testing
- Chlorhexidine and zinc application, Scaling and root planing with distilled water
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ataturk University
Gingival Diseases
Collection of Gingival Crevicular Fluid From Periodontitis Patients
To collect GCF (gingival crevicular fluid) samples from diseased patients suffering only from gingivitis and/or periodontitis.
- Trial name
- NCT00763048
- Testing
- Fluoride, Fluoride, triclosan
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontitis, Adult
Association of Periodontitis With Oral Health Related Quality of Life
Objective: The aim of this study was to investigate the impact of periodontitis on oral health-related quality of life (OHQoL) and the factors may associated with OHQoL.
- Trial name
- NCT04240015
- Testing
- Oral-Dental Health-Related Quality of Life-United Kingdom (OHRQoL-UK) scale
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baskent University
Biological Markers
Effect of Double Antibiotic Paste Versus Calcium Hydroxide on RANKL/OPG Levels
The aim of the present study is to evaluate the effect of double antibiotic paste when compared to Ca (OH)2, in terms of RANKL and OPG levels in chronic periapical lesions and correlate the results with periapical bone healing…
- Trial name
- NCT04593238
- Testing
- Double Antibiotic paste, Calcium Hydroxide Paste - Non-Setting
- Volunteers
- 50 people
- Sponsor
- Cairo University
Periodontitis
Efficacy of Local Doxycycline Gel Delivery Versus Doxycycline Nanoparticles Prepared Gel in The Treatment of Stage II Periodontitis
To evaluate the Efficacy of Local Doxycycline Gel Delivery Versus Doxycycline Nanoparticles Prepared Gel in The Treatment of stage II Periodontitis Materials and methods: forty five patients (n=45) were selected from the…
- Trial name
- NCT06994455
- Testing
- scaling and root planing along with antibiotic intervention, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
Periodontitis, Alveolar Bone Loss* / Therapy
Clinical Study of BMP-2 Injectable Hydrogel for Promoting Alveolar Bone Regeneration
This project aims to construct an injectable self-healing hydrogel loaded with BMP-2, with optimized gelation time and mechanical strength to meet the requirements for periodontal pocket filling, for the treatment of…
- Trial name
- NCT07611617
- Testing
- treatment group
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Quality of Life
Effects Of Different Periodontal Treatments On Quality Of Life In Patients With Periodontitis
In this study, the quality of life of patients with stage 3 grade C periodontitis who underwent surgical and non-surgical periodontal treatments was evaluated.
- Trial name
- NCT06539364
- Testing
- Quality of life surveys were conducted
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Katip Celebi University
Periodontal Disease, Periodontitis
Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE)
This study aims to evaluate the burden and phenotypic spectrum of periodontal disease in patients with rare kidney disorders (such as Alport syndrome, Fabry disease, and tuberous sclerosis complex) and systemic lupus…
- Conditions
- Periodontal Disease, Periodontitis, CKD, Chronic Kidney Disease
- Trial name
- PERIO-RA-RE (NCT07575347)
- Testing
- Observational assessment
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Stefan Lujinschi
Chronic Periodontitis, Smoking
MTZ Plus AMX in the Treatment of Smokers and Non-smokers
Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and microbiological outcomes of scaling and root planing…
- Trial name
- NCT01837199
- Testing
- Metronidazole plus Amoxicillin
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Guarulhos
Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications
Undiagnosed Diabetes in a Dental Setting
In an ongoing study new dental patients are screened to determine their risk of having undiagnosed pre-diabetes or diabetes based on risk factors readily known by the patient and signs of gum disease.
- Conditions
- Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications, Periodontal Pocket, Tooth Loss
- Trial name
- NCT01711385
- Testing
- Enhanced intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Columbia University
Schizophrenia Spectrum and Other Psychotic Disorders, Periodontal Diseases
Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
The aim of the present cohort retrospective study is to explore the effect of antipsychotics on periodontal health and the possible effect of antipsychotic-induced hyperprolactinemia as a risk factor for periodontal disease…
- Trial name
- NCT06040944
- Testing
- antipsychotic drugs inducing hyperprolactinemia
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Fayoum University
Chronic Periodontitis
Role of Infected Blood Dendritic Cells in Heart Disease Risk
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
- Trial name
- NCT01568944
- Testing
- Oral Antibiotic and Oral Rinse, Standard Treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Augusta University
Apical Periodontitis
Accuracy of ERCLMDs in Teeth With Apical Periodontitis
The aim of this in vivo study is to evaluate the influence of apical periodontitis (AP) on the accuracy of Dentaport ZX, Raypex 5, and i-Root electronic root canal length measurement devices.
- Trial name
- ERCLMDs (NCT01904552)
- Testing
- Electronic Root Canal Length Measurement Device
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Major Depressive Disorder, Periodontitis
Relationship Between Major Depression and Periodontal Diseases
Background: There are epidemiological and preclinical studies in vivo that support the biological plausibility of the association between periodontal diseases and major depression (DM), through the hypothesis of a "leaky mouth"…
- Trial name
- LeakyBraInCS (NCT05950009)
- Testing
- No intervention (observational studies)
- Where
- 2 sites in Spain
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Periodontal Disease, Periodontitis (Stage 3)
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
- Trial name
- OASP (NCT07673185)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Periodontitis
Kiwifruit Effect on Periodontal Inflammation Kiwifruit Effect on Periodontal Inflammation
The importance of micronutrients has been extensively reviewed and it was concluded that for prevention and treatment of periodontitis daily nutrition should include sufficient antioxidants, vitamin D and calcium.
- Trial name
- PERIO-KIWI (NCT03084484)
- Testing
- Kiwifruit addition to the diet, Non Surgical periodontal treatment
- Volunteers
- 50 people
- Sponsor
- University of Pisa
Periapical Periodontitis, Pulpitis
Postoperative Pain Evaluation After Obturation With Different Sealers
This study aims to evaluate the incidence and intensity of postoperative pain in patients undergoing root canal treatment on teeth diagnosed with pulpitis, pulp necrosis, or with previous endodontic treatment.
- Conditions
- Periapical Periodontitis, Pulpitis, Necorsis
- Trial name
- NCT07018284
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena
Periodontitis, Periodontal Pocket
Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel
In the here suggested study, the aim is to test non-surgical treatment of advanced periodontal disease with a chitosan brush with or without chitosan gel in patients with advanced periodontal disease having responded poorly to a…
- Conditions
- Periodontitis, Periodontal Pocket, Periodontal Diseases, Periodontal Inflammation
- Trial name
- Chitosangel (NCT05773911)
- Testing
- 4% chitosan gel (pH 3.48)., Reciprocal Chitosan brush
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Caspar Wohlfahrt
Periodontal Diseases
LED Light As An Adjunct Treatment Modality of Periodontal Diseases
By promoting the cellular activities, it has been shown that the low-level laser therapy (LLLT) is able to accelerate the wound healing, reduce gingival inflammation, relief the discomfort, and serve as an adjunct to the…
- Trial name
- NCT03557814
- Testing
- LED appliance during mechanical debridement, LED appliance after mechanical debridement, Mechanical debridement alone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
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