Clinical trials: Parodontitis
Periodontitis
Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment
Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss.
- Trial name
- NCT05583643
- Testing
- Atorvastatin Calcium, Scaling and debridement only
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Aggressive Periodontitis, Chronic Periodontitis
Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis
Periodontitis are inflammatory diseases characterized by the destruction of the tooth-supporting bone due to increased bone resorption by osteoclasts (OCLs).
- Trial name
- PAG (NCT01993368)
- Testing
- flow cytometry
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Periodontal Diseases
Fractal Analysis Method in Periodontal Disease
In this study, the effects of periodontal disease on alveolar bone were investigated using fractal analysis method.
- Trial name
- NCT05639582
- Testing
- fractal analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis
Role of Macrophage in Inflammation Resolution in Periodontal Patients
There is a growing body of evidence to suggest that the resolution of an inflammatory reaction is an active process. This process requiring signals that turn off early inflammatory stages, as neutrophil infiltration and promote…
- Trial name
- NCT01379950
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Periodontal Disease
Effect of Baduanjin Exercise on Chronic Periodontal Disease in Elderly
The metabolic syndrome (MetS) is a spectrum of conditions that increase the risk of cardiovascular disease and diabetes mellitus.
- Trial name
- NCT05484479
- Testing
- Baduanjin training/exercise
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Periodontitis, Periodontitis (Stage 3)
Evaluation of Albumin Platelet-Rich Fibrin Following SRP in Patients With Periodontitis
The study aims to investigate whether application of albumin platelet-rich fibrin (Alb-PRF) into the gum pockets after scaling and root planing (SRP) can improve healing in patients with Stage III Grade B periodontitis.
- Trial name
- NCT07363135
- Testing
- Albumin platelet-rich fibrin, Sterile saline (0.9%)
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Periodontitis
RELATIONSHIP BETWEEN INITIAL PROBING DEPTH AND CHANGES IN CLINICAL PARAMETERS FOLLOWING NON-SURGICAL PERIODONTAL TREATMENT IN CHRONIC PERIODONTITIS PATIENTS
Aim: The aim of this study was to evaluate the relationship between initial probing depth (IPD) and changes in clinical parameters following non-surgical periodontal treatment (NPT) in chronic periodontitis patients.
- Trial name
- NCT02861326
- Testing
- Gracey Curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontal Disease, Periodontitis (Stage 3)
Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis
Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values and clinical periodontal…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Periodontitis Stage III
- Trial name
- NCT06933797
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara University
Chronic Periodontitis, Type 2 Diabetes
The Periodontal Disease and Diabetes Mellitus Interrelationship Among Adult Malaysians
Periodontitis, a chronic inflammatory disease which results in irreversible attachment loss, bone destruction and tooth loss, is a major oral health problem affecting 90.2% of Malaysian population.
- Trial name
- NCT01951547
- Testing
- Nonsurgical periodontal therapy, Oral hygiene instructions
- Where
- Malaysia
- Volunteers
- 40 people
- Sponsor
- University of Malaya
Treatment of Stage III Periodontitis, Local Application of Insulin in Pockets
Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis
The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus…
- Trial name
- NCT07746206
- Testing
- Insulin, Hyaluronic acid gel, mechanical debridement
- Where
- 2 sites in Egypt
- Volunteers
- 45 people
- Sponsor
- Doaa Atta Aid
Periodontitis
The Safety and Tolerability of Initial Periodontal Therapy Combined With Human Dental Pulp Stem Cell Injection in the Treatment of Chronic Periodontitis
The principal objective of this trial is to investigate the safety and tolerability of human dental pulp stem cells injection in the treatment of chronic periodontitis.
- Trial name
- NCT04983225
- Testing
- Human Dental Pulp Stem Cells, Saline solution
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking University Third Hospital
Periodontitis
Impact of SRP on Bone Resorption and Systemic Inflammatory Markers in Postmenopausal Women With Periodontitis
This study is designed to determine the effect of treating postmenopausal women and using non-surgical techniques on biomarkers of systemic inflammation (IL-6 ) and systemic bone resorption (C-terminal collagen cross-links, CTX).
- Trial name
- NCT04261491
- Testing
- scaling and root planing
- Where
- 2 sites in India
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis
is the Sclerostin Marker of Chronic Periodontitis
Reviewed literature suggests that sclerostin will inhibit the bone formation and ultimately leads to chronic periodontitis. Estimation of Sclerostin levels in the serum of periodontitis patients before and after intervention…
- Trial name
- itsmcp (NCT03639636)
- Testing
- non surgical and surgical periodontal therapy
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis (Stage 3)
Assessment of Autogenous Dentin Graft in Treatment of Infra-bony Defect
The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.
- Trial name
- NCT05258006
- Testing
- Autogenous demineralized dentin nanoparticles
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- October 6 University
Dentoalveolar Abscess
C-reactive Protein Levels in Acute Apical Abscess Due to Root Canal Infection
C-reactive protein levels of patients with acute apical abscess are evaluated before and after root canal treatment
- Trial name
- NCT04684407
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CSI College of Dental Sciences and Research, Madurai
Pain, Postoperative
Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulps
Aim to compare acute pain rate after single-visit ortwo-visits treatment of teeth with necrotic pulp and apical periodontitis .90 teeth with a diagnosis of pulp necrosis and apical radiolucency at the apex.Working length was…
- Trial name
- Acute pain (NCT04115904)
- Testing
- Ibuprofen for post operative pain
- Where
- 4 sites in Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Periodontitis
Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis
Background: Aloe vera is considered to be the most promising and high-ranking agent as an all-purpose herbal plant amongst herbal agents used in dentistry.
- Trial name
- NCT02462993
- Testing
- Aloe Vera
- Volunteers
- 12 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Oral Lichen Planus, Periodontitis
Periodontal Status in Patients With Oral Lichen Planus
This case-control study will enroll 176 patients age- and sex- matched at the Oral Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.
- Trial name
- NCT07597616
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Diabetes Mellitus, Type 1, Periodontal Diseases
Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients
The aim of this study is to evaluate adjuvant effect of antimicrobial photodynamic therapy in periodontal treatment and salivary status of type 1 diabetes patients.
- Conditions
- Diabetes Mellitus, Type 1, Periodontal Diseases, Periodontal Pocket
- Trial name
- NCT03102892
- Testing
- Scaling root planing, Antimicrobial photodynamic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
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