Clinical trials: Parodontitis
Periodontitis, Type2 Diabetes
Serum Ferritin and Hepicidin Concentration in Chronic Periodontitis Patients With T2DM
serum level of ferritin and hepicidin were evaluated in periodontitis patient with and without type 2 diabetes before and after non surgical periodontal treatment to clarify their in periodontal disease
- Trial name
- NCT03964428
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Fayoum University
Periodontal Diseases, Periodontitis
Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population Using Semi-Supervised Learning
This observational study will collect labeled data to assess the accuracy of an online periodontal self-assessment tool in adults.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT07410351
- Testing
- Online periodontal self-assessment questionnaire and clinical periodontal examination (reference standard)
- Where
- Saudi Arabia
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Periodontal Disease, Periodontal Pockets
Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy
The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office.
- Conditions
- Periodontal Disease, Periodontal Pockets, Periodontal Attachment Loss
- Trial name
- NCT07446127
- Testing
- LASER assisted SRP, RsD
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel Aviv University
Periodontal Bone Loss
Evaluation of Non-Incised Papillae Surgical Approach (NIPSA) Versus Conventional Flap in Periodontal Reconstructive Surgery of Intrabony Defects (Clinical and Radiographic Study)
Objectives: To compare the effectiveness of Non-Incised Papillae Surgical Approach (NIPSA) versus conventional flap with mineralized Freeze-Dried Bone Allograft (FDBA) in periodontal reconstructive surgery of intrabony defects…
- Trial name
- NCT06647186
- Testing
- Non Incised Papillae Surgical Approach, Conventional flap design
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Bassant Hamdy Mowafey
Periodontal Diseases
Evaluation of Saliva IL-6 Levels and Periodontitis
The aim of this study was to analyze the association between salivary IL-6 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced salivary IL-6 levels
- Trial name
- NCT04382105
- Testing
- Observation of salivary IL-6 levels
- Where
- Italy
- Volunteers
- 287 people
- Sponsor
- University of Messina
Periodontal Disease
Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy.
The aim of this clinical study is to asses the effect of ultrasonic periodontal debridement associated to locally delivered doxycycline (20%) by PLGA microspheres on chronic generalized periodontitis treatment.
- Trial name
- NCT02487186
- Testing
- Doxicicline, Full-mouth debridment
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Apical Periodontitis
Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial
The relationship between different root canal irrigation techniques and pain after root canal treatment
- Trial name
- NCT07599254
- Testing
- root canal irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periodontitis, Adult
Protozoans in Biofilm From Patients With Periodontitis
The buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients.
- Trial name
- Paro-Proto (NCT03240666)
- Testing
- non applicable
- Where
- France
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Periodontitis
Effects of Nd:YAG Laser and Air Abrasive Combined Application in Patients With Periodontitis
The aim of this clinical study is to investigate the effectiveness of the combined application of Nd:YAG (neodymium-doped yttrium aluminum garnet) laser and air abrasive applied in addition to nonsurgical periodontal treatment on…
- Trial name
- NCT05101603
- Testing
- Air Abrasive, Nd:YAG Laser, Non surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Periodontitis
Impact of Pycnogenol® on Gingival Inflammation
This randomized, double-blind, placebo-controlled 2-arm, parallel group clinical trial is designed to evaluate the impact of the regular consumption of a polyphenol-containing Maritime Pine (Pinus pinaster) bark extract…
- Trial name
- PINEGIN (NCT05786820)
- Testing
- Pycnogenol
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Wuerzburg University Hospital
Periodontitis Chronic Generalized Moderate, Periodontitis
Effect of Periodontal Treatment on Metabolic Control in Patients with Type-2 Diabetes Mellitus Treated in the Cardiovascular Healt Program
The objective of this clinical trial is to evaluate the effect of periodontal treatment on the reduction of glycated hemoglobin levels in adult patients with concurrent type 2 diabetes mellitus and periodontitis.
- Conditions
- Periodontitis Chronic Generalized Moderate, Periodontitis, Periodontal Disease, Diabetes Mellitus Type 2
- Trial name
- T2D (NCT06895980)
- Testing
- Non-surgical periodontal treatment, glycated hemoglobin measurement and application of OHIP-14SP survey.
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- University of Chile
Periodontitis, Diagnoses Disease
The Impact of a Modified Probe Tip Design on Patient Perception of Discomfort on Probing and Clinical Parameters Using the Florida Probe® System
Patient perception of pain on periodontal probing using a controlled-force, electronic probe was not significantly affected by the use of a modified (ball-end) probe tip design except for in the maxilla, where a standard straight…
- Trial name
- NCT03690479
- Testing
- Florida Probe Straight Tip Probe, Ball Tip Probe
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Florida
Periodontal Diseases, Periodontitis and Treatment Need
Micro-Needling Technique Using Ozonated Olive Oil in Periodontal Diseases
The research idea is based on using micro-acupuncture therapy with ozone-treated olive oil to improve the condition of patients suffering from gingivitis and periodontitis and comparing it to the scientifically proven…
- Conditions
- Periodontal Diseases, Periodontitis and Treatment Need, Gingivitis
- Trial name
- NCT06990282
- Testing
- microneedling, scaling, Ozonated olive oil
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Fayoum University
Type 2 Diabetes Mellitus
Prolactin Levels in Type 2 Diabetic Patients With Stage III Periodontitis
evaluate the role of prolactin hormone in the pathogenesis of periodontitis by assessing its local gingival levels and assess clinical parameters in patients who have type two diabetes
- Trial name
- prolactin (NCT06941246)
- Testing
- Non Surgical Periodontal Treatment, paper points, ELISA Kits
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Oral Biofilm, Dental Plaque
Essential Oils With and Without Alcohol: Substantivity and Antiplaque Effect
The Essential oils (EO) are composed by a wide diversity of products. Therefore, their antimicrobial activity will be related to their composition, configuration, amount and their possible interaction.
- Conditions
- Oral Biofilm, Dental Plaque, Periodontitis
- Trial name
- NCT03146390
- Testing
- Essential oils, Alcohol free essential oils, Water
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Periodontitis
Prevalence of Treponema Parvum in Subgingival Microbiome of Patients With Periodontitis
The current study primarily aims to evaluate the presence of T. parvum in periodontal health and disease, and its correlation with clinical parameters.
- Trial name
- NCT07443917
- Where
- Iraq
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontal Diseases, Periodontal Inflammation
Therapeutic Application of Coconut Oil in Oral Health
The scientific literature has verified that coconut oil has properties that open perspectives for its application in order to maintain oral health and, in particular, for the treatment of different oral pathologies.
- Conditions
- Periodontal Diseases, Periodontal Inflammation, Periodontal Attachment Loss, Periodontitis
- Trial name
- NCT06049589
- Testing
- Coconut Oil, Chlorhexidine mouthwash, Water mouthwash
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinica Pardinas
Snoring, Mouth Breathing
Does myTAP Oral Appliance Therapy Including a Mouth Shield Lessen Periodontitis in Mouth-Breathers Who Snore?
Mouth breathing, snoring and poor sleep can contribute to and worsen periodontitis (gum disease). The purpose of this study is to test whether the myTAP oral appliance with a mouth shield (OA+) can lessen periodontal symptoms in…
- Conditions
- Snoring, Mouth Breathing, Daytime Sleepiness, Periodontitis
- Trial name
- OAplusPerio (NCT06797089)
- Testing
- Oral appliance therapy plus scaling and root planing on left or right of mouth
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Periodontitis Chronic Generalized Severe
Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial
Periodontitis is an inflammatory pathology that destroys periodontitis and causes tooth loosening. Its high incidence, combined with very high oral and systemic morbidity, places this pathology at the heart of global public…
- Trial name
- HERPARO (NCT05902208)
- Testing
- Antiviral treatment with conventional non-surgical treatment
- Where
- 3 sites in France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
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