Clinical trials: Parodontitis
Chronic Periodontitis
Study on Treatment Results and Bone Changes After Replanting Severely Affected Teeth - A Before-and-After Study.
This research aims to evaluate the effectiveness of intentional replantation (IR) as a treatment for single-rooted teeth diagnosed as hopeless due to true periodontic lesions.
- Trial name
- NCT06893107
- Testing
- Intentional Replantation
- Where
- United Arab Emirates
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Fujairah
Chronic Periodontitis
Randomized Clinical Trial of Enamel Matrix Derivative: Radiographic Analysis
This is a split-mouth, double-blind randomized controlled trial. Computerized linear radiographic measurements were used to detect infrabony defects treated with open flap debridement (OFD) or OFD associated with enamel matrix…
- Trial name
- NCT02195765
- Testing
- enamel matrix derivative, Open flap debridement
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Periodontal Health, Periodontitis Stage III
EVALUATION OF SALIVA AND SERUM HEME OXYGENASE, ARYLESTERASE AND NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 LEVELS IN PATIENTS WITH STAGE III PERIODONTITIS
Periodontal disease is a chronic and progressive inflammatory disease in which the hard and soft tissues that support the teeth are damaged.
- Trial name
- NCT06986044
- Testing
- Serum Total Oxidant Status, Salivary Total Oxidant Status, Serum Total Antioxidant Status
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Periodontitis
The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis
Evaluation of clinical and microbiological effect of lactobacillus reuteri probiotics.
- Trial name
- NCT04697199
- Testing
- Lactobacillus Reuteri Oral Drops, Scaling and root planing
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Tanta University
Chronic Periodontitis
Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care
Chronic periodontitis is a common infectious disease characterized by progressive attachment loss and alveolar bone resorption eventually resulting in tooth loss.
- Trial name
- Listerine (NCT01195493)
- Testing
- Essential Oils solution, negative control solution
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Chronic Periodontitis
Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket
application of 1% curcumin gel in clinical study design will be used . The study will be conducted in Al-Najaf specialised dentistry center.
- Trial name
- NCT04355416
- Testing
- curcumin Oral gel, subgingival scaling and root planing
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontitis
Probiotics as Adjunctive Therapy in the Management of Periodontitis
The goal of this clinical trials is to learn about the effect of taking Prodentis on a long term basis following periodontal therapy. The main question it aims to answer is 1.
- Trial name
- NCT07531875
- Testing
- Prodentis
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- University of Malaya
Periapical Periodontitis, MMP-9
Relationship Apical Periodontitis and the Main Bacterial Species in the Oral Microbiota
Aim: Apical periodontitis(AP) caused by root canal infection is the most frequent pathological lesion in the jaws. Bacterial products, host immune cells and biologically active factors called locally produced cytokines(such as…
- Trial name
- NCT05857436
- Testing
- apical periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Apical Periodontitis, Atherosclerotic Cardiovascular Disease
Association Between Apical Periodontitis and Atherosclerotic Cardiovascular Diseases
The aim of the study is to evaluate the association between apical periodontitis (AP) and atherosclerotic cardiovascular disease (ASCVD) by assessing the multiplicative effect of AP on secondary outcomes of ASCVD.
- Trial name
- NCT05792787
- Testing
- Echo-color-doppler
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- University of Siena
Dental Hygiene, Probiotics, Periodontitis
Probiotic Nanofiber Floss and Subgingival Pathogen Suppression
This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals.
- Conditions
- Dental Hygiene, Probiotics, Periodontitis, Prevention of Dental Caries, Gingivitis and Periodontal Diseases
- Trial name
- NCT07149493
- Testing
- Probiotic nanofiber floss
- Where
- Czechia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Periodontitis, Tongue Coating
Effect of Periodontal Treatment on Tongue Coating and Smell Function
This study aims to investigate the effect of periodontal treatment on olfactory function in patients with periodontitis by comparing pre- and post-treatment periodontal indices, Winkel tongue coating scores, and Sniffin' Sticks…
- Conditions
- Periodontitis, Tongue Coating, Olfactory Dysfunction
- Trial name
- EPTOS (NCT07326319)
- Testing
- Non-Surgical Periodontal Treatment (Scaling and Root Planing
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Batman University
Periodontitis, Biomarker in Early Diagnosis
Discovery and Validation of Periodontitis Biomarkers
Periodontitis is a major public health issue in China: it is responsible for loss of masticatory function in 60 million older adults, and 400-500 million adults are on the same disease trajectory.
- Conditions
- Periodontitis, Biomarker in Early Diagnosis, Saliva
- Trial name
- NCT07293481
- Testing
- Diagnostic procedures
- Where
- China
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Chronic Periodontitis
Glucosamine Periodontal Adjunctive Therapy
This study is the first evidence based work evaluated the systemic use of glucosamine as an adjunctive therapy to closed mechanical debridement in chronic periodontitis.
- Trial name
- NCT02214095
- Testing
- glucosamine sulphate, lactose capsules
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis
Periodontitis and Inflammation: Study on Biological Samples
Periodontitis is a major public health problem because it is widespread in the adult population. It leads to the irreversible destruction of the anchoring tissues of the teeth, and represents a modifiable risk factor for systemic…
- Trial name
- CB-PARO2 (NCT06012019)
- Testing
- Biological sampling in Periodontitis Case, Biological sampling in Gingivitis Case, Biological sampling in Control Case
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontitis, Type 2 Diabetes Mellitus (DM)
Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis
Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth and can lead to progressive tissue destruction.
- Trial name
- NCT07905209
- Testing
- MTHFR and DNMT3B Genetic Polymorphism Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Alveolar Bone Loss, Periodontitis
Zirconia Vs Titanium Implants in Deficient Ridges
The aim of this study is to evaluate clinically and radiographically soft tissue around single-implant crowns and peri-implant bone resorption respectively by using zirconia implants or titanium implants in horizontally deficient…
- Trial name
- NCT04375839
- Testing
- Zirconia implant, Titanium implant
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Two Irrigation Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection, Irrigation Activation
- Trial name
- NCT05690763
- Testing
- XP-endo Finisher to use irrigation activation, EndoActivator to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Parodontitis Aggressive, Parodontitis Chronic
Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis
The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses.
- Trial name
- NCT01246648
- Testing
- Biopsy
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gingivitis and Periodontal Diseases, Periodontitis
Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax
This prospective observational study aims to investigate the prevalence and clinical significance of two oral protozoa, Entamoeba gingivalis and Trichomonas tenax, among patients attending the Bolu Abant İzzet Baysal University…
- Trial name
- NCT07551115
- Testing
- Clinical Periodontal Evaluation, Microscopic Examination of Oral Protozoa
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
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