Clinical trials: Parodontitis
Chronic Periodontitis
1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers
Locally delivered Alendronate (ALN) have potent inhibitory effect on bone and increases new bone formation in chronic periodontitis patients Till date no study has reported the effect of local delivery of ALN in chronic…
- Trial name
- NCT02168543
- Testing
- Alendronate
- Volunteers
- 46 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Pocket
Investigation of the Safety and Efficacy of Pocket-X Gel
This study is an open-label split-mouth study in which Pocket-X Gel, a periodontal in-situ gelling product, will be applied to periodontal pockets in one/two mouth segment(s) of participants, following scaling and root planing on…
- Trial name
- NCT03358251
- Testing
- Pocket-X Gel, Scaling and root planing
- Where
- 2 sites in Israel
- Volunteers
- 34 people
- Sponsor
- Tree of Life Pharma Ltd.
Periodontitis, Biomarker in Early Diagnosis
Discovery and Validation of Periodontitis Biomarkers
Periodontitis is a major public health issue in China: it is responsible for loss of masticatory function in 60 million older adults, and 400-500 million adults are on the same disease trajectory.
- Conditions
- Periodontitis, Biomarker in Early Diagnosis, Saliva
- Trial name
- NCT07293481
- Testing
- Diagnostic procedures
- Where
- China
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Periodontitis
Oral Gel Containing PHTALOX® as an Adjuvant in the Treatment of Periodontal Disease
Periodontitis, a chronic inflammatory condition of the periodontal tissues, impacts not only the patient's oral and systemic health but also has significant social and economic implications.
- Trial name
- NCT06731777
- Testing
- Scaling and root planing plus PHTALOX® oral gel vehicle, Scaling and root planing plus 0.12% chlorhexidine oral gel, Scaling and root planing plus PHTALOX® oral gel
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal de Alfenas
Periodontal Diseases, Wound Heal
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined…
- Conditions
- Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket
- Trial name
- NCT06309719
- Testing
- Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA), Periodontal Access Flap (AF)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
Platelet-Rich Fibrin
Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
In this study, the possible effect of blood group distribution on the content of blood biomaterial was investigated. 64 volunteers were included in the study. Various parameters were evaluated.
- Trial name
- NCT05409495
- Testing
- periodontal surgical procedure (open flap debridement), periodontal surgical procedure (OFD +autogenous Titanium-prepared platelet-rich fibrin (OFD+ T-PRF))
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Halitosis
Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis
The aim of this trial was to establish the clinical efficacy of Listerine and chlorhexidine (CHX) when used as a cooling agent with ultrasonic instrumentation, on periodontal parameters and halitosis.
- Trial name
- NCT03468595
- Testing
- ultrasonic (Piezon Master 700) performed with Listerine, ultrasonic (Piezon Master 700) performed with CHX, ultrasonic (Piezon Master 700) performed with serum
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Periodontal Diseases, Dysbiosis
Effect of Aerosol From THS and Cigarette Smoke on Periodontal Tissues and Its Microbiome
Cigarette smoke has an adverse effect on the entire body as well as on the supporting apparatus of the teeth. THS (tobacco heating system) are new products on the market in which tobacco is heated and not burned like in classic…
- Trial name
- NCT06480877
- Testing
- Taking a swab from periodontal pockets or gingival sulci
- Where
- Croatia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Periodontal Disease, Melatonin
Adjunctive Topical Melatonin Gel in Non-Surgical Periodontal Therapy for Periodontitis
The goal of this clinical trial is to evaluate the clinical effectiveness of adjunctive topical melatonin gel when used with non-surgical periodontal therapy (NSPT) in adult patients with periodontitis.
- Trial name
- NCT07605767
- Testing
- Topical 5% Melatonin Gel
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Periodontitis, Obesity
EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITIS
Obesity and periodontitis are chronic inflammatory diseases that share common pathological mechanisms. Asprosin, a novel adipokine discovered in 2016, has not been extensively studied in relation to periodontal tissues.
- Trial name
- NCT06879951
- Testing
- Participants are not assigned an intervention as part of the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontitis, Heart Valve Disease
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery
This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.
- Conditions
- Periodontitis, Heart Valve Disease, Postoperative Infection, Cardiovascular Disease
- Trial name
- Perio-CVS (NCT07626801)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Apical Periodontitis of Pulpal Origin
Cytokine Regulation of Periradicular Pain in Humans
This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis
- Trial name
- NCT00223470
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Periodontitis
Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel
assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planning (SRP) in chronic moderate to severe periodontitis patients…
- Trial name
- NCT03311906
- Testing
- 0.8% Hyaluronic Acid, Scaling and Root Planing
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications
Undiagnosed Diabetes in a Dental Setting
In an ongoing study new dental patients are screened to determine their risk of having undiagnosed pre-diabetes or diabetes based on risk factors readily known by the patient and signs of gum disease.
- Conditions
- Prediabetic State, Type 2 Diabetes Mellitus With Oral Complications, Periodontal Pocket, Tooth Loss
- Trial name
- NCT01711385
- Testing
- Enhanced intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Columbia University
Periodontal Disease, Periodontitis
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis
Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.
- Trial name
- PRFperio (NCT06920849)
- Testing
- SRP+iPRF, SRP
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Periodontal Health, Periodontitis
Gingival Crevicular Fluid, Salivary, and Serum Biomarkers Levels in Periodontal Treatment
The present study aimed to assess the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF), saliva, and serum IL-26, IL-6, and IL-10 levels in stage III grade B periodontitis (SIII-GB-P) and C…
- Trial name
- NCT05395455
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Marmara University
Diabetes Mellitus Type 2
Oxidative Stress Markers Evaluation Before and After Periodontal Treatment of Diabetics Type 2 Patients
Abstract Diabetes mellitus and periodontal diseases are both chronic inflammatory disorders that have a major impact on the health and well being of millions of individuals worldwide.
- Trial name
- NCT01475435
- Testing
- non- surgical periodontal treatment, Prophylaxis
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periapical Periodontitis
Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.
The aim of the study is to assess the correlation between pre-obturation bacterial detection using fluorescence amplification and outcome of endodontic treatments.
- Trial name
- NCT03660163
- Volunteers
- 65 people
- Sponsor
- King's College London
Apical Periodontitis, Anxiety
Apical Periodontitis and Mental Health
This study is investigating the relationship between anxiety, depression and apical periodontitis (AP), a common oral inflammatory condition.
- Conditions
- Apical Periodontitis, Anxiety, Depression
- Trial name
- NCT06589076
- Testing
- Clinical and Radiographic assessment + Questionnaires
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Siena
Periodontitis, Gingivitis
(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis
NLRC4, an inflammasome , is a cytosolic multiprotein complex involved in the initiation and modulation of the immune response. Periodontitis is a chronic inflammatory disease that can start with localized inflammatory reactions…
- Conditions
- Periodontitis, Gingivitis, Healthy
- Trial name
- NCT04850768
- Testing
- Saliva, gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
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